Mutational landscape of DDR2 gene in lung squamous cell carcinoma using next-generation sequencing

DDR2 alterations were identified as a promising therapeutic target in lung SCC. Using a large cohort, DDR2 genetic landscape was assessed by next-generation-sequencing. DDR2 mutations are present in 4% of SCC, are not exclusive with driver genes alterations, and have no prognosis impact. This study emphasizes the need for a better knowledge of DDR2 biology before developing dedicated targeted therapies.

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