Publication date: 1 December 2017
Source:Cancer Letters, Volume 410
Author(s): Bryan Hoang, Mark J. Ernsting, Wei-Hsin Sophia Tang, Joseph Bteich, Elijus Undzys, Taira Kiyota, Shyh-Dar Li
Effective treatment of metastatic castration resistant prostate cancer (mCRPC) remains an unmet challenge. Cabazitaxel (CBZ) is approved for mCRPC after docetaxel (DTX) failure, but the improvement in survival is only moderate (∼2 months) and patients suffer from significant side effects. Here, we report the development of a polymer based delivery system for CBZ to improve its safety and efficacy against DTX-resistant mCRPC. CBZ was conjugated to a carboxymethylcellulose-based polymer (Cellax-CBZ), which self-assembled into ∼100 nm particles in saline and exhibited sustained drug release in serum at 10%/day. Cellax-CBZ delivered 157-fold higher CBZ to PC3-RES prostate tumor in mice and could be safely administered at a 25-fold higher dose compared to free CBZ, resulting in superior tumor inhibition in multiple mice models of DTX-resistant CRPC. In a metastatic bone model of CRPC, Cellax-CBZ significantly improves overall survival with a 70% long-term survival rate to day 120, while mice treated with free CBZ had a median survival of 40 days. Cellax-CBZ induced mild and reversible neutropenia in mice but no other tissue damage. Cellax-CBZ showed significant potential for improving therapy of mCRPC over clinically approved CBZ.
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2kwps3L
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
-
▼
Οκτωβρίου
(11955)
-
▼
Οκτ 08
(180)
- Dr Hilmi Yahaya denies supporting jailed bogus den...
- Parsing the neural correlates of anxious apprehens...
- Parsing the neural correlates of anxious apprehens...
- Essential oils as antibacterial agents against foo...
- Properties of spray-dried fish oil with different ...
- Effect of different operating conditions in cloud ...
- Effect of packaging types and storage conditions o...
- Transitions in mesocarp colour of mango fruits kep...
- MicroRNAs: A novel potential biomarker for diagnos...
- Berberine inhibits the chemotherapy-induced repopu...
- IFI16 restoration in hepatocellular carcinoma indu...
- Mesenchymal-like stem cells in canine ovary show h...
- SurvivorCHESS to increase physical activity in col...
- Treatment decisions and employment of breast cance...
- Intestinal toxicity of deoxynivalenol is limited b...
- Drug-eluting bead transarterial chemoembolization ...
- Women who undergo aggressive surgery for breast ca...
- A comparison of two tools to screen potentially in...
- Gibson Dental Designs launches new branding, website
- Recurrent nevus as a pitfall of melanoma diagnosis...
- Toward multi-day-ahead forecasting of suspended se...
- Clinical Guidance for Managing Statin and Antimicr...
- Auricular hematoma
- Vitamin D and the Skin: An Update for Dermatologists
- Antimicrobial Efficacy of Synthetic Pyranochromeno...
- Cabazitaxel-conjugated nanoparticles for docetaxel...
- Onychomycoses in a Military Population in Brazil
- Dual Src and EGFR inhibition in combination with g...
- An inexact multistage fuzzy-stochastic programming...
- Neuro-Psychiatric Comorbidity among Psoriatic Adol...
- Dental assistant program growing at LCC
- On My Shelf: What's Love Got to Do With It?
- On My Shelf: What's Love Got to Do With It?
- Virulence and Antimicrobial Resistance in Campylob...
- Usage Patterns of Electric Bicycles: An Analysis o...
- Cancer Metabolism and Tumor Heterogeneity: Imaging...
- A Comparison of the Device-Related Complications o...
- Tubulin-dependent secretion of S100A6 and cellular...
- Disseminated cryptococcosis in a patient taking to...
- Graham dentist is celebrating 30 years in dental f...
- Evaluating the Solar Slowly Varying Component at C...
- Evolution of catalytic microenvironment governs su...
- Autonomic nervous system and pancreatic islet bloo...
- LncRNA CPS1-IT1 suppresses EMT and metastasis of c...
- A 360-degree view of an ancient killer disease
- Inducible NAD(H)-linked methylglyoxal oxidoreducta...
- Effects of Retinoic Acid Signaling on Extraocular ...
- Biomechanical strain-induced modulation of prolife...
- Discordant HIV Test Results: Implications on Perin...
- The Utility of MRI in the Diagnosis of Takayasu Ar...
- Response to the letter to the editor regarding “Th...
- Comparison of gene co-expression networks in Pseud...
- Erosive Pustular Dermatosis of the Scalp with Urat...
- Cytomegalovirus Associated Duodenal Ulcer and Duod...
- Distributed Hybrid Precoding for Indoor Deployment...
- Bee-Inspired Algorithms Applied to Vehicle Routing...
- Hydroxyurea therapy in UK children with sickle cel...
- Comment on: Value of flow cytometric analysis of p...
- Cognitive outcomes among Latino survivors of child...
- Comparison of two cytoreductive regimens for αβ-T-...
- Immature platelet fraction in immune thrombocytope...
- Survival of renal cell carcinoma metastatic to non...
- Upper esophageal sphincter augmentation reduces ph...
- How reliably can computed tomography predict thyro...
- Risk factors for salvage surgery failure in oral c...
- Safety of outpatient thyroidectomy: Review of the ...
- What antibiotic should be used in the management o...
- Expression and Immunogenicity of Two Recombinant F...
- A Study of Photocatalysis of Methylene Blue of TiO...
- A Community-Based Nutrition and Physical Activity ...
- Smart Microgrid Energy Management Using a Novel Ar...
- Evaluation of Catalytic Effects of Chymotrypsin an...
- Blocking AGE-RAGE Signaling Improved Functional Di...
- New Insights into the Benefits of Physical Activit...
- Simultaneous determination of fluoxetine and norfl...
- Thiamine Deficiency Leading to Refractory Lactic A...
- DOA Estimation of Noncircular Signals Using Quater...
- Study on Selfish Node Incentive Mechanism with a F...
- quality of care; +28 new citations
- Pain control following tonsillectomy in children: ...
- Jasmonates are signals in the biosynthesis of seco...
- A Rare Variant in PGAP2 Causes Autosomal Recessive...
- Adaptive Antenna Null Broadening Beamforming again...
- Effects of Bedtime Periocular Warming on Sleep Sta...
- Separation of Electrolytic Reduction Product from ...
- D-Shaped Left Ventricle, Anatomic, and Physiologic...
- Pediatric Pulmonary Epstein-Barr Virus-Positive Di...
- Structural requirements of flavonoids to induce he...
- UCP2 inhibition induces ROS/Akt/mTOR axis: Role of...
- Redox imbalance due to the loss of mitochondrial N...
- Latanoprost Induced Iris Pigment Epithelial and Ci...
- Technology-Assisted Rehabilitation of Writing Skil...
- Thermal Emission of Alkali Metal Ions from Al30-Pi...
- Immediate completion lymph node dissection in stag...
- Utility of Risk Stratification for Paclitaxel Hype...
- Severe Asthma and the Primary Care Provider: Ident...
- Health-related quality of life in children with co...
- Vertical-cavity surface-emitting laser sources for...
- In vivo diabetic wound healing with nanofibrous sc...
- Crystal structure of Mycobacterium tuberculosis Va...
-
▼
Οκτ 08
(180)
- ► Σεπτεμβρίου (12424)
Ετικέτες
Πληροφορίες
Κυριακή 8 Οκτωβρίου 2017
Cabazitaxel-conjugated nanoparticles for docetaxel-resistant and bone metastatic prostate cancer
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,