Pioglitazone decrease intrapulmonary shunt in biliary cirrhotic rats with hepatopulmonary syndrome

Hepatopulmonary syndrome (HPS) is a severe complication of liver cirrhosis which is characterized by deoxygenation in cirrhotic patients. Three important components of HPS are: (1) hypoxia with increased alveolar-arterial oxygen gradient (AaPO2); (2) increased intrapulmonary shunts; and (3) chronic liver disease.1 Schenk et al. reported that cirrhotic patients with severe hypoxia (PaO2 <60 mmHg) would die within 6 months.1 Liver transplantation is the only well-established strategy to improve 5-year survival and resolution of hypoxemia for cirrhotic patients with severe HPS.

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