Differential Diagnosis of Fever in Patients with Hematologic Malignancy Receiving Chemotherapy: A Retrospective Cohort Study in Japan

Patients with hematologic malignancies are susceptible to infection due to myelosuppression during chemotherapy administration. In addition, presentation of various fevers in conjunction with chemotherapy is well known, these include tumor fever, drug fever, febrile neutropenia, and systemic bacterial infections. Dental focal infections such as severe periodontitis have been reported to cause life-threatening systemic morbidity and an adverse impact on the chemotherapy schedule. It is challenging for clinicians to make a diagnosis and identify the source of the fever as an adverse oral event.

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