The role of Helicobater pylori as an aetiological factor for rosacea

Bothaina M Ghanem, Ayman A.M. El-Kholy, Nabieh A El-Ghawalby, Farha A El-Chennawy, Samia M Abdel Naby

Egyptian Journal of Dermatology and Venerology 2017 37(2):49-55

Background Rosacea is a chronic cutaneous disorder characterized by persistent centrofacial erythema, telangiectases, papules, pustules, oedema, phymatous and ocular involvement. Despite being one of the most common skin disorders, its pathogenesis remains unclear and controversial. More recently, numerous studies have described an association with Helicobacter pylori. Objective This study was undertaken to investigate the prevalence of H. pylori in rosacea patients by performing gastroscopic biopsy, and if its eradication is a useful therapy for rosacea. Patients and methods This study was conducted on 54 patients with rosacea: 46 women and eight men, in addition to 26 healthy controls of similar age and socioeconomic status. Blood samples were taken from patients, and controls for the detection of H. pylori immunoglobulin G antibodies by enzyme-linked immunosorbent assay. Also, gastroduodenoscopy was done for 28 patients with rosacea, and two punch biopsies were taken for direct Gram stain, direct urease test and culture. Results Bacteriological tests were positive in 11 of these 28 (39.3%) patients. Seropositive prevalence was significantly higher in the rosacea group than in the control group (81.5 vs. 57.7%). On intake of H. pylori eradication therapy in the form of amoxicillin 500 mg/6 h and metronidazole 500 mg, thrice daily, for 10 days, the H. pylori positive group showed significant improvement in rosacea severity. Conclusion Our results suggest that H. pylori is a risk factor that may cause or aggravate rosacea condition. Its eradication leads to a favourable clinical outcome.

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