Granulomatous cheilitis involving the lower lip

Pragya A Nair, Trusha M Patel

Egyptian Journal of Dermatology and Venerology 2017 37(2):85-88

Granulomatous lesions of the oral and oropharyngeal submucosal tissues refer to painless, idiopathic swelling frequently affecting the buccal and labial areas. They present a diagnostic dilemma because of the wide variety of possible etiologic factors. Granulomatous cheilitis should be considered in the differential diagnosis of persistent lip swelling. It can occur in isolation as a monosymtomatic form or as a part of Melkersson–Rosenthal syndrome, which is a triad of recurrent orofacial swelling, relapsing facial paralysis, and fissuring of the tongue (lingua plicata). Spontaneous remission is rare, and recurrences are common. Corticosteroids used for treatment provide temporary improvement. A combination of intralesional triamcinolone and clofazimine or dapsone is one of the most commonly used treatment options. We present the case of a 21-year-old young man with granulomatous cheilitis who responded to intralesional steroids and dapsone.

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