Selective changes in locomotor activity in mice due to low-intensity microwaves amplitude modulated in the EEG spectral domain.

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Selective changes in locomotor activity in mice due to low-intensity microwaves amplitude modulated in the EEG spectral domain.

Neuroscience. 2017 Jul 04;:

Authors: Eeghem VV, Arfani AE, Anthoula A, Walrave L, Pourkazemi A, Bentea E, Demuyser T, Smolders I, Stiens J

Abstract
Despite the numerous benefits of microwave applications in our daily life, microwaves were associated with diverse neurological complaints such as headaches and impaired sleep patterns, and changes in the electroencephalogram (EEG). To which extent microwaves influence the brain function remains unclear. This exploratory study assessed the behavior and neurochemistry in mice immediately or 4 weeks after a 6-day exposure to low-intensity 10 GHz microwaves with an amplitude modulation (AM) of 2 or 8 Hz. These modulation frequencies of 2 and 8 Hz are situated within the delta and theta-alpha frequency bands in the EEG spectrum and are associated with sleep and active behavior, respectively. During these experiments, the specific absorbance rate was 0.3 W/kg increasing the brain temperature with 0.23°C. For the first time, exposing mice to 8 Hz AM significantly reduced locomotor activity in an open field immediately after exposure which normalized after 4 weeks. This in contrast to 2 Hz AM which didn't induce significant changes in locomotor activity immediately and 4 weeks after exposure. Despite this difference in motor behavior, no significant changes in striatal dopamine and DOPAC levels and DOPAC/dopamine turnover nor in cortical glutamate concentrations were detected. In all cases, no effects on motor coordination on a rotarod, spatial working memory, anxiety nor depressive-like behavior were observed. The outcome of this study indicates that exposing mice to low-intensity 8 Hz AM microwaves can alter the locomotor activity in contrast to 2 Hz AM which did not affect the tested behaviors.

PMID: 28687311 [PubMed - as supplied by publisher]

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