Colonisation of Irish patients with chronic obstructive pulmonary disease by Streptococcus pneumoniae and analysis of the pneumococcal vaccine coverage: a non-interventional, observational, prospective cohort study: Objectives
To characterise the pattern of colonisation and serotypes of Streptococcus pneumoniae among patients with chronic obstructive pulmonary disease (COPD) who currently receive the 23-valent pneumococcal polysaccharide vaccine (PPV-23) according to vaccination status, use of antibiotics and steroids. To investigate the prevalence of PPV-23 and 13-valent pneumococcal conjugate vaccine (PCV-13) serotypes within the study cohort.
Design
A non-interventional, observational, prospective cohort study with a 12 -month follow-up period inclusive of quarterly study visits.
Setting
Beaumont Hospital and The Royal College of Surgeons in Ireland Clinical Research Centre, Dublin, Ireland.
Participants
Patients with an established diagnosis of COPD attending a tertiary medical centre.
Primary outcome measure
Colonisation rate of S. pneumoniae in patients with COPD and characterisation of serotypes of S. pneumoniae with correlation to currently available pneumococcal vaccines. Sputum and oropharyngeal swab samples were collected for the isolation of S. pneumoniae.
Secondary outcome measure
Seasonality of colonisation of S. pneumoniae and its relationship with the incidence of exacerbations of COPD.
Results
S. pneumoniae was detected in 16 of 417 samples, a colonisation incident rate of 3.8% and in 11 of 133 (8%) patients at least once during the study. The majority of S. pneumoniae isolates were identified in spring and were non-vaccine serotypes for either the PPV-23 or PCV-13 (63%). The colonisation incident rate of S. pneumoniae fluctuated over the four seasons with a peak of 6.6% in spring and the lowest rate of 2.2% occurring during winter. Antibiotic use was highest during periods of low colonisation.
Conclusions
There is seasonal variation in S. pneumoniae colonisation among patients with COPD which may reflect antibiotic use in autumn and winter. The predominance of non-vaccine types suggests that PCV-13 may have limited impact among patients with COPD in Ireland who currently receive PPV-23.
Trial registration number
NCT02535546; post-results.
from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2u8bF7l
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
- ► Σεπτεμβρίου (12424)
-
▼
Ιουλίου
(12782)
-
▼
Ιουλ 09
(242)
- Doxycycline staph boils - Doxycycline treat tooth ...
- Implementing the Synchronized Global Switch from T...
- Transition Planning For After Polio Eradication
- Addressing the Challenges and Opportunities of the...
- Lessons Learned and Legacy of the Stop Transmissio...
- Cold-Chain Adaptability During Introduction of Ina...
- The Switch From Trivalent to Bivalent Oral Poliovi...
- Assessing Inactivated Polio Vaccine Introduction a...
- Lessons Learned From Managing the Planning and Imp...
- The Public Health Legacy of Polio Eradication in A...
- Administering Multiple Injectable Vaccines During ...
- Intradermal Administration of Fractional Doses of ...
- Introduction of Inactivated Polio Vaccine, Withdra...
- Lessons From Globally Coordinated Cessation of Ser...
- Impact of an Intervention to Use a Measles, Rubell...
- Lessons From the Polio Endgame: Overcoming the Fai...
- Using Acute Flaccid Paralysis Surveillance as a Pl...
- Considerations for the Full Global Withdrawal of O...
- Underlying maternal infection likely cause of stud...
- Family physicians support Open Pharma [News]
- Postpartum hypertension [Practice]
- Delivering timely surgery in Canadian hospitals [C...
- The authors respond to "Underlying maternal infect...
- Spoon versus knife [Humanities]
- Using thermography responsibly [Letters]
- Pulling together [Coda]
- Functional Neurology
- Cancer risk among Holocaust survivors in Israel—A ...
- Extreme population-level events: Do they have an i...
- High level of tobacco carcinogen-derived DNA damag...
- Characteristics of adverse drug reactions in a vem...
- Selection of DNA aptamers for extra cellular domai...
- FOTROCAN Delphi consensus statement regarding the ...
- Hearing Preservation and Bimodal Listening
- The Clinical Evaluation of Angioedema.
- Angiotensin-converting Enzyme Inhibitor and Other ...
- Acquired C1 Inhibitor Deficiency.
- Laboratory Approaches for Assessing Contact System...
- Prophylactic Therapy for Hereditary Angioedema.
- Hereditary Angioedema with Normal C1 Inhibitor: Up...
- Burden of Illness and Quality-of-Life Measures in ...
- Pharmacoeconomics of Orphan Disease Treatment with...
- Recent Advances in Adhesive Bonding: The Role of B...
- Use of Statins Is Associated with a Reduced Incide...
- Young and advanced tumor—some 2D electrodynamic di...
- Parental knowledge, attitudes and beliefs on fever...
- Colonisation of patients with chronic obstructive ...
- The linguistic and interactional factors impacting...
- Aptamer-assisted novel technologies for detecting ...
- Erratum to: Underreporting of congenital rubella i...
- Maternal use of prednisolone is unlikely to be ass...
- Facilitating mental health help-seeking by young a...
- The linguistic and interactional factors impacting...
- Colonisation of Irish patients with chronic obstru...
- Menstrual hygiene management among Bangladeshi ado...
- Open reduction and internal fixation of humeral sh...
- Temporal changes in predicted risk of type 2 diabe...
- Normative visual acuity in Chinese preschoolers ag...
- A systematic review of the worldwide prevalence of...
- Non-withdrawal of beta blockers in acute decompens...
- Parental knowledge, attitudes and beliefs on fever...
- Prevalence of pregnancy-related complications and ...
- Prevalence of metabolic syndrome, discrete or como...
- Challenges and Opportunities in Studying the Epide...
- Response to Vogelstein: How the 2012 AAP Task Forc...
- Ricostruita la laringe con muscoli del collo dopo ...
- Eruptive vellus hair cysts of the vulva
- Court upholds $28M verdict in Connecticut smoker c...
- Expected to die decades ago, Kate Vines has learnt...
- Liver Disease in Alpha-1 Antitrypsin Deficiency: C...
- Nolvadex and proviron - Organic apple cider vinega...
- Relay for Life: Remembering those who have succumb...
- Impact of Carbohydrate-Electrolyte Beverage Ingest...
- Comprehensive Treatments for Congenitally Missing ...
- Efficient Physical-Layer Secret Key Generation and...
- mTOR Signaling in Cardiometabolic Disease, Cancer,...
- What Are the Factors Influencing Implementation of...
- Pedestrian Dead Reckoning Navigation with the Help...
- Pharmacy Professionals’ Dispensing Practice, Knowl...
- Relationship between Microstructure and Properties...
- Cisplatin-Induced Nephrotoxicity and HIV Associate...
- Three-Dimensional Vehicle-to-Vehicle Channel Model...
- Identifying High-Cost, High-Risk Patients Using Ad...
- A Comparison of Off-Grid-Pumped Hydro Storage and ...
- Online propecia order - Propecia side effects pros...
- Expected to die decades ago, Kate Vines has learnt...
- Evaluation of the possible protective role of nari...
- The first sporadic case of DFNA11 identified by ne...
- Evaluation of the possible protective role of nari...
- The first sporadic case of DFNA11 identified by ne...
- Facing Cancer Is Even Tougher If The Only Radiatio...
- RNAi prodrugs targeting Plk1 induce specific gene ...
- Macrophage migration inhibitory factor promotes os...
- Court Upholds $28M Verdict in Connecticut Smoker C...
- Generic propecia canada pharmacy - Propecia thyroi...
- Expected to die decades ago, Kate Vines has learnt...
- Veterinary cancer specialists california - Dissolv...
- 7 signs of cancer you simply cannot ignore - Glouc...
- NYU Dentistry's Dr. Nicole N. Scheff Receives $120...
- THEMIS: Two Models, Different Thresholds
-
▼
Ιουλ 09
(242)
Ετικέτες
Πληροφορίες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,