Advances in ultrasound-targeted microbubble-mediated gene therapy for liver fibrosis

Publication date: July 2017 Source:Acta Pharmaceutica Sinica B, Volume 7, Issue 4 Author(s): Cuiyuan Huang, Hong Zhang, Ruidan Bai Hepatic fibrosis develops as a wound-healing scar in response to acute and chronic liver inflammation and can lead to cirrhosis in patients with chronic hepatitis B and C. The condition arises due to increased synthesis and reduced degradation of extracellular matrix (ECM) and is a common pathological sequela of chronic liver disease. Excessive deposition of ECM in the liver causes liver dysfunction, ascites, and eventually upper gastrointestinal bleeding as well as a series of complications. However, fibrosis can be reversed before developing into cirrhosis and has thus been the subject of extensive researches particularly at the gene level. Currently, therap...

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