Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)

xlomafota13 shared this article with you from Inoreader Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Dec;22(6):1462. doi: 10.3892/etm.2021.10897. Epub 2021 Oct 20. ABSTRACT Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily identified in mammals so far and widely expressed in cells and tissues. As it is involved in numerous sensory disorders such as pain and pruritus, TRPA1 is a potential target for the treatment of neuropathy. The functions of TRP family members are closely related to Ca2+. TRPA1 has a high permeability to Ca2+, sodium and potassium ions as a non-selective cation channel and the Ca2+ influx mediated by TRPA1 is involved in a variety of biological p rocesses. In the present review, research on the relationship between the TRPA1 channel and Ca2+ ions and their interaction in disease-associated processes was summarised. The therapeutic potential of the TRPA1 channel is highlighted, which is expected to become a novel direction for the prevention and treatment of health conditions such as cancer and neurodegenerative diseases. PMID:34737802 | PMC:PMC8561754 | DOI:10.3892/etm.2021.10897 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.