Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway

xlomafota13 shared this article with you from Inoreader Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway Via Experimental and therapeutic medicine Exp Ther Med. 2021 Aug;22(2):899. doi: 10.3892/etm.2021.10331. Epub 2021 Jun 23. ABSTRACT The present study aimed to investigate the effects of zhike pingchuan granules (ZKPC) on bronchial asthma and the underlying mechanism. A bronchial asthma mouse model was established by aerosol inhalation of ovalbumin. The changes in lung pathomorphology were observed by hematoxylin and eosin staining. The levels of IL-1β, TNF-α and IL-6 in bronchoalveolar lavage fluid (BALF) and serum were detected by corresponding ELISA kits. Levels of reactive oxygen species, malondialdehyde and superoxide dismutase in lung tissues were analyzed using corresponding kits. The expression of proteins related to apoptosis and the IL-6/janus kinase 2 (JAK2)/STAT3 pathway was detected by western blot analysis. The results showed that ZKPC significantly restored the dry/wet ratio and alleviated lung pathomorphology of bronchial asthmatic mice. In addition, ZKPC inhi bits inflammation, oxidative stress levels and cell apoptosis in bronchial asthmatic mice and also suppressed the IL-6/JAK2/STAT3 pathway. Fedratinib (a JAK2 inhibitor) further strengthened the alleviative effects of ZKPC on bronchial asthma. In conclusion, ZKPC improved bronchial asthma by suppressing the IL-6/JAK2/STAT3 pathway. PMID:34257712 | PMC:PMC8243345 | DOI:10.3892/etm.2021.10331 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.