Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis.

xlomafota13 shared this article with you from Inoreader Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis. Via radioactive iodine Related Articles Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis. Cancers (Basel). 2020 Nov 04;12(11): Authors: Tabatabaeian H, Peiling Yang S, Tay Y Abstract Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer. PMID: 33158279 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.