The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men.

ola Kala shared this article with you from Inoreader The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men. Μέσω The Journal of Clinical Endocrinology & Metabolism The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men. J Clin Endocrinol Metab. 2020 Oct 19;: Authors: Yang L, Demetriou L, Wall MB, Mills EG, Wing VC, Thurston L, Schaufelberger CN, Owen BM, Abbara A, Rabiner EA, Comninos AN, Dhillo WS Abstract CONTEXT: The hormone kisspeptin has crucial and well-characterised roles in reproduction. Emerging data from animal models also suggest that kisspeptin has important metabolic effects including modulation of food intake. However, to date there have been no studies exploring the effects of kisspeptin on brain responses to food stimuli in humans. OBJECTIVE: To investigate the effects of kisspeptin administration on brain responses to visual food stimuli and psychometric parameters of appetite in healthy men. DESIGN: Double-blinded, randomized, placebo-controlled crossover study. PARTICIPANTS: Twenty-seven healthy, right-handed, eugonadal men (mean±SEM: age 26.5±1.1 yrs; BMI 23.9±0.4 kg/m 2). INTERVENTION: Intravenous infusion of 1 nmol/kg/hr of kisspeptin or rate-matched vehicle over 75 minutes.Main Outcome Measures: Change in brain activity on functional MRI in response to visual food stimuli and change in psychometric parameters of appetite during kisspeptin administration compared to vehicle. RESULTS: Kisspeptin administration at a bioactive dose did not affect brain responses to visual food stimuli or psychometric parameters of appetite compared to vehicle. CONCLUSIONS: This is the first study in humans investigating the effects of kisspeptin on brain regions regulating appetite and demonstrates that peripheral administration of kisspeptin does not alter brain responses to visual food stimuli or psychometric parameters of appetite in healthy men. These data provide key translational insights to further our understanding of the interaction between reproduction and metabolism. PMID: 33075807 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.