Novel Platinum(II) Complex-based Luminescent Probe for Detection of Hypochlorite in Cancer Cells.

ola Kala shared this article with you from Inoreader Novel Platinum(II) Complex-based Luminescent Probe for Detection of Hypochlorite in Cancer Cells. Μέσω pubmed: cancer platinum Novel Platinum(II) Complex-based Luminescent Probe for Detection of Hypochlorite in Cancer Cells. Photochem Photobiol. 2020 Oct 19;: Authors: Tang J, Huang D, Meng F, Li P, Peng F, Huang J Abstract Hypochlorite (ClO⁻) is of great importance either for the metabolism of living organisms or as disinfectant in daily life. However, improper concentration levels of ClO⁻ lead to serious health problems including erythrocyte damage, cardiovascular problems, neuron degeneration, lung/kidney injury, and cancer. Therefore, a sensitive and selective detection method is required for the visualization and measurement of ClO⁻. In this work, a novel platinum(II) complex-based luminescent probe Pt-CHO was synthesized and utilized to detect ClO⁻. This "turn off" probe exhibits high sensitivity, excellent selectivity, good pH stability, low limit of detection, and instantaneous response ability. Moreover, the luminescent response is caused by the oxidation of aldehyde into carboxyl groups combined with the coordination of hydroxyl groups at the Pt center, which is rarely reported. The cell imaging of HeLa cells proved the considerable potential of the probe for ClO⁻ imaging in living cells. PMID: 33078394 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.