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IJERPH, Vol. 17, Pages 6768: High-Performance Ha... Humanities, Vol. 9, Pages 113: The Historical Lan... IJERPH, Vol. 17, Pages 6767: Accessing Occupatio... Auditory Brainstem Response in Preterm Infants in... HER2-positive human breast carcinoma SK-BR-3 cel... Association of Clinicopathological Features With... heory of COVID-19 pathogenesisPublication date: N... Non-invasive assessment of endothelial dysfunction... antibodies targeting modified ribonucleotides [MET... buccal mucoadhesive films for photodynamic inactiv... Improved Antimicrobial Properties of Methylene Blu... Efficacy of aminolevulinic acid 20% solution combi... Microelectrode Recording and Radiofrequency Thalam... Percutaneous Foramen Ovale Puncture: Usefulness of... Circumferential Subannular Tympanoplasty: Panacea ... Paleontology: The oldest known sperm cells Proprioception but not cardiac interoception is re... A Pandemic within a Pandemic — Intimate Partner Vi... Fecal Microbiome Alteration May Be a Potential Mar... Dosimetric feasibility of hypofractionation for SB... Pancreatic ascites managed with a conservative app... A rare case of multisystemic langerhans cell histi... Erosive pustular dermatosis after CO2 Laser resurf... Gamma Knife Radiosurgery as a Primary Treatment fo... Comparison of autologous platelet-rich plasma and ... Cutaneous squamous cell carcinoma presenting with ... Dyskeratosis congenita: reticulate hyperpigmentat... Primary, Secondary, and Tertiary Effects of Carboh... Effects of Cold Atmospheric Pressure Plasma and Di... Laser‐assisted nucleic acid delivery Analysis of drug sensitivity of human high-grade o... CD8+ T Cell Infiltration Predicts Chemoradiosensit... Cellular and molecular mechanisms in fibrosis MicroRNA-92a Inhibits the Cell Viability and Metas... Determining the significance of psammoma bodies in... Fine needle aspiration cytomorphology of papillary... The Paris System for reporting urinary cytology Loeys‐Dietz syndrome (LDS), a connective tissue di... Totally Robotic Caudate Lobe Liver Resection Effects of nerve‐sparing procedures on bowel funct... negative automatic thoughts Deregulated immune cell recruitment orchestrated b... mutational signatures in head and neck cancer Reasons behind the rapid increase of thyroid cance... Optimal management of esophageal cancer Nintedanib plus mFOLFOX6 as second‐line treatment ... Polygenic hazard score (PHS) models are associated... Nasopharyngeal Carcinoma in Children and Adolescents Overdiagnosis in lung cancer screening Value of upper GI endoscopy for gastric cancer sur... Prophylaxis of Post-Inflammatory Hyperpigmentation... Management of an Imminent Pathological Fracture of... preoperative microvessel evaluation and characteri... Galectin-3 not Galectin-9 as a candidate prognosis... Neuromodulation in Psychiatric disorders: Experime... Cortical responses to whole‐body balance perturbat... Modulation of binocular rivalry with rapid monocul... chitinase‐3‐like protein 1 in recurrence patterns ... Lungs Infected With Sars‐Cov 2.......Immunohistoch... Functional Communication Profiles of Children and ... Perirolandic atrophy occurs in corticobasal syndro... Fear of Cancer Recurrence in Patients with Multipl... electronic psychosocial screening in pediatric onc... losatuxizumab vedotin (ABBV-221), an anti-EGFR ant... Intratumoral submicron particle docetaxel inhibits... Novel Bacillus strains from the human gut exert an... adjuvant trastuzumab on locoregional failure rates carbon‐ion radiotherapy for patients with locoregi... Association between postoperative complications an... Hyperthermic intraperitoneal chemotherapy in inter... 5-ALA-mediated photodynamic therapy on oral squamo... Early fiberoptic endoscopic evaluation of swallow ... Transoral robotic parapharyngeal approach to the s... nodal and distant metastases in sinonasal adenocar... Pediatric Rigid Bronchoscopy for Tracheobronchial ... Iodine Concentration in Dual-Energy Computed Tomog... MRI Techniques for Imaging Blood-Brain Barrier Int... Fusion of Preinterventional MR Imaging With Liver ... CT Dosimetry: What Has Been Achieved and What Rema... A Magnetic Resonance Imaging Radiomics Signature t... Left heart bypass versus circulatory arrest for op... Systematic review of perioperative mortality risk ... Gene signatures from scRNA‐seq accurately quantify... Acute Cholecystitis during Lenvatinib for Advanced... Insulin‐induced amyloidoma—A cytological catch Low Diagnostic Yield of Repeat Blood Cultures in A... Biallelic intronic AAGGG expansion of RFC1 is rela... Positive selection within the genomes of SARS-CoV-... The tumour immune landscape and its implications i...
Non-invasive assessment of endothelial dysfunction: A novel method to predict severe COVID-19?: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Sarangini Yoganandamoorthy, M.A.D.S.N. Munasinghe, L.V.U. Wanigasuriya, M.K.K. Priyankara, Saroj JayasingheMethods of Endothelial Function Assessment: Description and ...www.scielo.br › scieloAssessment of endothelial function consists of the analysis of endothelial cells responsiveness to vasodilator or vasoconstrictor stimuli,...
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Validation strategies for antibodies targeting modified ribonucleotides [METHOD]: Chemical modifications are found on almost all RNAs and affect their coding and noncoding functions. The identification of m6A on mRNA and its important role in gene regulation stimulated the field to investigate whether additional modifications are present on mRNAs. Indeed, modifications including m1A, m5C, m7G, 2'-OMe, and were detected. However, since their abundances are low and tools used for their corroboration...
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Development and <em>in vitro</em> evaluation of buccal mucoadhesive films for photodynamic inactivation of <em>Candida albicans</em>: Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Camila Felix Vecchi, Rafaela Said dos Santos, Jéssica Bassi da Silva, Hélen Cassia Rosseto, Karina Mayumi Sakita, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça, Marcos Luciano Bruschi
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Improved Antimicrobial Properties of Methylene Blue Attached to Silver Nanoparticles: Publication date: Available online 15 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Ermek Belekov, Khomidkhodza Kholikov, Lauren Cooper, Simran Banga, Ali O. ErView allSilver nanoparticles are nanoparticles of silver of between 1 nm and 100 nm in size. While frequently described as being 'silver' some are composed of a large percentage of silver oxide due to their large ratio of surface...
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Efficacy of aminolevulinic acid 20% solution combined with photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial: Publication date: Available online 15 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Brian Berman, Neal Bhatia, Daniel Piacquadio, Anna Houlihan, David Davidson, Daniel Siegel
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Microelectrode Recording and Radiofrequency Thalamotomy following Focused Ultrasound Thalamotomy: Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is a novel method for stereotactic brain lesioning and has primarily been applied for thalamotomies to treat essential tremor (ET). The electrophysiological properties of previously MRgFUS-sonicated thalamic neurons have not yet been described. We report on an ET patient who underwent an MRgFUS thalamotomy but experienced tremor recurrence....
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Percutaneous Foramen Ovale Puncture: Usefulness of Intraoperative CT Control, in the Eventuality of a Narrow Foramen: Background: Balloon compression of the gasserian ganglion has been a well-established percutaneous treatment of trigeminal neuralgia since the 1980s. However, puncture of the foramen ovale by conventional single-plane fluoroscopy can be difficult in cases of local anatomic abnormalities. Case Presentation: We present the case of a 49-year-old woman diagnosed with idiopathic trigeminal...
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Circumferential Subannular Tympanoplasty: Panacea for revision tympanoplasty: Publication date: Available online 16 September 2020Source: American Journal of OtolaryngologyAuthor(s): Gautam Bir Singh, Devanshu Kwatra, Sonali Malhotra, Sunil Kumar
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Paleontology: The oldest known sperm cells: An international team of paleontologists has discovered giant sperm cells in a 100-million year-old female ostracod preserved in a sample of amber. Clearly, the tiny crustacean had mated shortly before being entombed in a drop of tree resin.
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Proprioception but not cardiac interoception is related to the rubber hand illusion: Publication date: Available online 16 September 2020Source: CortexAuthor(s): Áron Horváth, Eszter Ferentzi, Tamás Bogdány, Tibor Szolcsányi, Michael Witthöft, Ferenc Köteles
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A Pandemic within a Pandemic — Intimate Partner Violence during Covid-19: As Covid-19 cases surged in the United States in March 2020, stay-at-home orders were put in place. Schools closed, and many workers were furloughed, laid off, or told to work from home. With personal movement limited and people confined to their homes, advocates expressed concern about a potential…
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Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer: Although intestinal microbial dysbiosis was confirmed to be associated with many chronic diseases and health status through complicated interaction with the host, the effect on gastric cancer was less studied. In this study, we sequenced the 16S rRNA and 18S rRNA genes of fecal bacteria and fungi, respectively, in 134 gastric cancer patients and 58 healthy controls matched by age and gender. Propensity score matching (PSM)...
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Dosimetric feasibility of hypofractionation for SBRT treatment of lymph node oligometastases on the 1.5T MR-linac: Stereotactic body radiation therapy (SBRT) is a non-invasive treatment option which is often considered for focal ablation of oligometastatic disease or primary tumours which are not suitable for surgical resection [1–3]. In SBRT a relatively high irradiation dose is delivered in a limited number of fractions to the target in a highly conformal manner with steep dose gradients to achieve...
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Pancreatic ascites managed with a conservative approach: a case report: Pancreatic ascites refers to the massive accumulation of pancreatic fluid in the peritoneal cavity and is a rare entity. Chronic alcoholic pancreatitis is the most common cause. Ascites is commonly seen in pat...
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A rare case of multisystemic langerhans cell histiocytosis mimicking diffuse neonatal hemangiomatosis:
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Erosive pustular dermatosis after CO2 Laser resurfacing in mother and daughter:
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Gamma Knife Radiosurgery as a Primary Treatment for Nonfunctioning Pituitary Adenoma Invading the Cavernous Sinus: Objectives: Surgical resection of nonfunctioning pituitary adenoma (NFPA) invading the cavernous sinus (CS) remains a challenging and significant factor associated with incomplete resection. The residual tumor in CS is usually treated with adjuvant stereotactic radiosurgery (SRS), but there is little information concerning SRS as an initial treatment for CS-invading NFPA. In this study,...
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Comparison of autologous platelet-rich plasma and chitosan in the treatment of temporomandibular joint osteoarthritis: a retrospective cohort study: Publication date: Available online 16 September 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Fu-Long Li, Chuan-Bin Wu, Hai-Jiang Sun, Qing Zhou
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Cutaneous squamous cell carcinoma presenting with facial paralysis: good response to Cemiplimab:
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Dyskeratosis congenita: a literature review: SummaryDyskeratosis congenita is a rare hereditary disease that occurs predominantly in males and manifests clinically as the classic triad of reticulate hyperpigmentation, nail dystrophy and leukoplakia. It increases the risk of malignancy and other potentially lethal complications such as bone marrow failure, lung and liver diseases. Mutations in 19 genes are associated with dyskeratosis congenita, and a fifth of the pathogenic mutations are found in...
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Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise: AbstractThe purpose of this current opinion paper is to describe the journey of ingested carbohydrate from 'mouth to mitochondria' culminating in energy production in skeletal muscles during exercise. This journey is conveniently described as primary, secondary, and tertiary events. The primary stage is detection of ingested carbohydrate by receptors in the oral cavity and on the tongue that activate reward and other...
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Effects of Cold Atmospheric Pressure Plasma and Disinfecting Agents on Candida albicans in Root Canals of Extracted Human Teeth: AbstractReinfection in endodontically treated teeth is linked to the complexity of the root canal system, which is problematic to reach with conventional disinfection methods. As plasma is expected to have the ability to sanitize narrow areas, the aim of this study was to analyze the effect of cold atmospheric pressure plasma (CAP) on Candida albicans in root canals of...
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Laser‐assisted nucleic acid delivery: A systematic review: AbstractGene therapy has become an effective treatment modality for some conditions. Laser light may augment or enhance gene therapy through photomechanical, photothermal, and photochemical. This review examined the evidence base for laser therapy to enhance nucleic acid transfection in mammalian cells. An electronic search of MEDLINE, Scopus, EMBASE, Web of Science, and Google Scholar was performed, covering all available years. The PRISMA...
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Analysis of drug sensitivity of human high-grade osteosarcoma in a chick chorioallantoic membrane (CAM) model: a proof of principle study: AbstractObjectiveMulti-agent chemotherapy is an important pillar in treatment of high-grade osteosarcoma. In an effort to improve patient survival, it is imperative to determine the effectiveness of new substances. The objective of this study was to investigate whether the chick chorioallantoic membrane (CAM) model can be used to analyze drug sensitivity in high-grade...
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CD8+ T Cell Infiltration Predicts Chemoradiosensitivity in Nasopharyngeal or Oropharyngeal Cancer: ObjectivesLimited information exists regarding the associations between pre‐existing immune parameters in the tumor immune microenvironment (TIM) and either chemoradiosensitivity or prognosis for patients with squamous cell carcinoma of the nasopharynx or oropharynx involving virus‐related or nonvirus‐related tumors.Study DesignRetrospective cohort study.MethodsWe retrospectively reviewed 141 patients...
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Cellular and molecular mechanisms in fibrosis: AbstractThe activation of fibroblasts is required for physiological tissue remodeling such as wound healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain persistently activated, the progressive deposition of extracellular matrix proteins leads to tissue fibrosis, which results in dysfunction or even loss of function of the affected organ. Although fibrosis has been recognized as a major cause of morbidity and mortality...
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MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. MicroRNAs (miRNAs) was confirmed to play an active role in the pathogenesis of prostate cancer (PCa). The expression and biological function for miR-92a in PCa remains unknown. In this study, we demonstrated that miR-92a expression was decreased in PCa tissues and cells lines. Overexpression miR-92a inhibited the cell...
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Determining the significance of psammoma bodies in pelvic washings: A 10‐year retrospective review: BackgroundPelvic washing specimens are relatively common and are submitted for patients undergoing gynecologic surgery to evaluate them for metastatic or occult disease. Psammoma bodies are a relatively uncommon finding in these specimens. To date, large‐scale studies of their cytologic‐histologic correlates and thus clinical significance have been limited.MethodsA 10‐year retrospective search for...
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Fine needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology: BackgroundNeurotrophic tyrosine kinase receptor (NTRK) rearrangement has been reported in a subset of papillary thyroid carcinoma (PTC) cases. Little is known about the cytomorphologic features of NTRK‐rearranged PTC.MethodsWe report an institutional series of 13 fine needle aspiration (FNA) specimens of NTRK‐rearranged PTC with a predominantly...
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Significant reduction of indeterminate (atypical) diagnosis after implementation of The Paris System for reporting urinary cytology: A single‐institution study of more than 27,000 cases: BackgroundUrinary cytology is a noninvasive and cost‐effective diagnostic and surveillance test in the clinical management of urothelial carcinoma (UC). The Paris System for Reporting Urinary Cytology (TPS), published in 2016, introduced definite diagnostic criteria aimed at improving performance in detecting high‐grade...
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The first reported case of Loeys‐Dietz syndrome in a patient with biallelic SMAD3 variants: AbstractLoeys‐Dietz syndrome (LDS), a connective tissue disorder characterized by its vascular, skeletal, craniofacial, and cutaneous manifestations is caused by mutations in one of six genes (TGFBR1, TGFBR2, SMAD2, SMAD3, TGFB2, and TGFB3). Until recently, all reported cases of LDS have been attributed to heterozygous pathogenic variants in these genes. Here, we report the first case of Loeys‐Dietz syndrome...
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Totally Robotic Caudate Lobe Liver Resection: Bridge Over Troubled Water (with video): AbstractBackgroundMinimally invasive hepatectomy has well known advantages over the traditional open approach. Inherent limitations of laparoscopy make major hepatectomies and the resection of upper and posterior segments a great technical challenge. The robotic approach overcomes most of these limitations and this technology is most useful in the resection of the deeply located caudate lobe.MethodsWe describe...
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Effects of nerve‐sparing procedures on bowel function after robot‐assisted radical prostatectomy: A longitudinal study: AbstractBackgroundThis study aimed to evaluate rectal pain and bowel function of the patients following robot‐assisted radical prostatectomy (RARP).MethodsWe divided 296 patients who underwent RARP into two groups depending on the intervention: NS group (bilateral nerve‐sparing (NS), unilateral NS, bilateral partial NS) and non‐NS group (unilateral partial NS, bilateral non‐NS)....
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Psychometric properties of the Automatic Thoughts Questionnaire-8 in two Spanish nonclinical samples: Background The ATQ is a widely used instrument consisting of 30 items that assess the frequency of negative automatic thoughts. However, the extensive length of the ATQ could compromise its measurement efficiency in survey research. Consequently, an 8-item shortened version of the ATQ has been developed. This study aims to analyze the validity of the ATQ-8 in two Spanish samples....
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Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing:
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Unraveling most abundant mutational signatures in head and neck cancer: AbstractGenomic alterations are a driving force in the multistep process of head and neck cancer (HNC) and result from the interaction of exogenous environmental exposures and endogenous cellular processes. Each of these processes leaves a characteristic pattern of mutations on the tumor genome providing the unique opportunity to decipher specific signatures of mutational processes operative during HNC pathogenesis and to address...
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Screening and the Epidemic of Thyroid Cancer in China: An Analysis of National Representative Inpatient and Commercial Insurance Databases: AbstractReasons behind the rapid increase of thyroid cancer (TC) in China are uncertain. We assessed the burden of TC and the role of access to screening and salt iodization. We analyzed two national databases in China: Hospital Quality Monitoring System (HQMS) and China Reinsurance Company (CRC) database. HQMS covered 1,037 (44.3%) class 3 hospitals and 76,263,617...
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Optimal management of esophageal cancer in Africa: A systemic review of treatment strategies: ABSTRACTEsophageal cancer (EC) is a leading cause of cancer morbidity and mortality in Africa. Despite the high burden of disease, optimal management strategies for EC in resource‐constrained settings have yet to be established. This systematic review evaluates the literature on treatments for EC throughout Africa, and compares the efficacy and safety of varying treatment strategies in this context (PROSPERO...
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Nintedanib plus mFOLFOX6 as second‐line treatment of metastatic, chemorefractory colorectal cancer: the randomized, placebo‐controlled, phase II TRICC‐C study (AIO‐KRK‐0111): AbstractNintedanib is a triple angiokinase‐inhibitor of VEGF‐receptor 1‐3, FGF‐receptor 1‐3 and PDGF‐receptor‐a/‐b. Thereby it targets angiogenic escape mechanisms. The TRICC‐C trial evaluates the addition of nintedanib to mFOLFOX6 in patients with mCRC. TRICC‐C is a randomized controlled, double‐blinded, phase II trial in mCRC...
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African‐specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer: AbstractPolygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46), showed reduced performance in men with African genetic ancestry. We used a cross‐validated search to identify SNPs that might improve performance in this population. Anonymized genotypic data were obtained from the PRACTICAL consortium for 6,253 men with African...
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Clinicopathological and Prognostic Features of Nasopharyngeal Carcinoma in Children and Adolescents: A Retrospective Study of 196 Cases in South China: AbstractNasopharyngeal carcinoma (NPC) occurring in children and adolescence is extremely rare and till present there is a lack of understanding on their clinicopathological and prognostic features of this rare entity. For this study, data of 196 cases children and adolescents with NPC from the past 18 years at a high‐volume cancer center from South...
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Overdiagnosis in lung cancer screening – estimates from the German Lung Cancer Screening Intervention Trial.: AbstractOverdiagnosis is a major potential harm of lung cancer screening; knowing its potential magnitude helps to optimize screening eligibility criteria.The German Lung Screening Intervention Trial ("LUSI") is a randomized trial among 4052 long‐term smokers (2622 men), 50.3‐71.9 years of age from the general population around Heidelberg, Germany, comparing five annual rounds of low‐dose...
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Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome: AbstractIn this study we evaluated the effectiveness of upper GI endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analysing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicentre cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was...
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Prophylaxis of Post-Inflammatory Hyperpigmentation From Energy-Based Device Treatments: A Review: Journal of Cutaneous Medicine and Surgery, Ahead of Print. Post-inflammatory hyperpigmentation (PIH) is an acquired hypermelanosis that can result from inflammatory dermatologic disease, trauma, or iatrogenesis from procedures. This condition disproportionately affects individuals with skin of color, and it can place a significant psychosocial burden on affected patients. The management of PIH is, therefore,...
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Management of an Imminent Pathological Fracture of a Fibular Neomandible Via a Minimally‐Invasive Approach – A Case Report: AbstractFibular free flap reconstruction remains the workhorse of the post‐mandibulectomy reconstruction. Dental implantation to support a dental prosthesis is a sought‐after outcome when the area of resection involves tooth‐bearing zones.Chronic peri‐soft tissue pedicle hyperplasia with secondary infection leading to gradual bone loss is a simple complication to manage in the...
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Feasibility study of preoperative microvessel evaluation and characterization in perforator flaps using various modes of color‐coded duplex sonography (CCDS): AbstractBackgroundColor‐coded duplex sonography (CCDS) is useful for perforator flap design showing the highest sensitivity in identifying microvessels. This prospective study evaluates the feasibility of different ultrasound (US) modes applied by the microsurgeon in daily practice suggesting quantifiable reference values.MethodsTwenty‐four...
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Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma: Background Galectins (Gal) are a family of protein that bind to the β-galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis. A series of experimental and clinical evidences have been reported to support a correlation between galectin expressions and neoplastic transformation, progression and prognosis. The objective...
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Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation – Focus on the medial forebrain bundle: AbstractDeep Brain Stimulation (DBS) in psychiatric illnesses has been clinically tested over the past 20 years. The clinical application of DBS to the superolateral branch of the medial forebrain bundle in treatment resistant depressed patients – one of several targets under investigation ‐ has shown to be promising in a number...
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Cortical responses to whole‐body balance perturbations index perturbation magnitude and predict reactive stepping behavior: AbstractThe goal of this study was to determine whether the cortical responses elicited by whole‐body balance perturbations were similar to established cortical markers of action monitoring. Postural changes imposed by balance perturbations elicit a robust negative potential (N1) and a brisk increase of theta activity in the electroencephalogram recorded over midfrontal scalp...
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Modulation of binocular rivalry with rapid monocular visual stimulation: AbstractRapid visual stimulation can increase synaptic efficacy by repeated synaptic activation. This long‐term potentiation‐like (LTP‐like) effect can induce increased excitability in the human visual cortex. To examine the effect of rapid visual stimulation on perception, we tested the hypothesis that rapid monocular visual stimulation would increase the dominance of the stimulated eye in a binocular rivalry task. Participants...
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Exploring the role of chitinase‐3‐like protein 1 in recurrence patterns among patients with differentiated thyroid cancer: a commentary: AbstractOur understanding of the oncogenic drivers involved in thyroid cancers continues to expand. In a recent issue of this journal, Cheng et al explore the role of Chitinase‐3‐like protein 1 (CHI3L1) in the development of thyroid cancer and its recurrence. They show increased levels of CHI3L1 in papillary and anaplastic thyroid malignancies (PTC and ATC, respectively)...
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Pathological Post Mortem Findings in Lungs Infected With Sars‐Cov 2: AbstractItaly was the first European nation to be massively infected by SARS‐COV 2. Up to the end of May 2020 more than thirty‐three thousand deaths had been recorded in Italy with a large prevalence among males, those over 75 years of age, and in association with co‐morbidities. We describe the lung pathological and immunohistochemical post‐mortem findings at the autopsy of 9 patients who died of SARS‐COV 2 associated disease....
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Functional Communication Profiles of Children and Youth with Autism: A Roadmap to Therapeutic and Educational Interventions: Background: Autism spectrum disorder (ASD) entails varied developmental pathways along the entire lifespan, demanding early and ongoing diverse and responsive interventions to children's needs. This study examined in situ education and development attained by children and youth with ASD in a school with a therapeutic and educational curriculum. Objectives: (1) Construct individual...
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Network localization of alien limb in patients with corticobasal syndrome: OBJECTIVEPerirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific vs. progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS‐specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion‐induced disorders...
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Fear of Cancer Recurrence in Patients with Multiple Myeloma: Prevalence and Predictors Based on a Family Model Analysis: AbstractObjectiveFear of cancer recurrence (FCR) is a common psychosocial sequela among cancer survivors, but data on patients with multiple myeloma are scarce. This study calculated the prevalence of FCR and identified family and social factors that predict FCR in the study population.MethodsWe recruited 127 myeloma patients and their partners to participate in a cross‐sectional...
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Using formative evaluation to plan for electronic psychosocial screening in pediatric oncology: AbstractObjectiveTo demonstrate how formative research methods can be used to plan for implementation of evidence‐based psychosocial screening in pediatric oncology.MethodsMultidisciplinary pediatric oncology professionals participated in focus groups to adapt the Distress Thermometer (DT) for electronic administration and develop health systems processes to promote psychosocial screening in the pediatric...
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A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR: SummaryLosatuxizumab vedotin (formerly ABBV-221) is a second-generation antibody-drug conjugate targeting epidermal growth factor receptor (EGFR). In this multicenter phase 1 study, eligible patients with EGFR-dependent solid tumors received losatuxizumab vedotin (3 + 3 design) intravenously...
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Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood: SummaryAdministration of chemotherapeutics as direct injections into tumors offers increased anti-tumor activity and reduced systemic toxicity. In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects of intratumoral (IT) submicron particle docetaxel (NanoDoce®) on tumor growth and immunomodulation....
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Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types: SummaryCancer is one of the leading causes of death worldwide, but effective therapies remain the topic of many research activities. Many recent studies have thus focused on particular gut microbiota due to their important roles in treating cancers, but very few microbes of therapeutic value have been reported. In this study, we isolated four bacterial strains, BY38, BY40, BY43 and BY45, from...
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Impact of adjuvant trastuzumab on locoregional failure rates in a randomized clinical trial: North Central Cancer Treatment Group N9831 (alliance) study: BackgroundThe goal of this study was to assess the impact of trastuzumab on locoregional failure.METHODSThe analysis included 2763 patients with HER2‐positive (HER2+) breast cancer who were randomly assigned to adjuvant doxorubicin (A), cyclophosphamide (C), paclitaxel (T) and trastuzumab (H) (arm A, AC→T [n = 922]; arm B, AC→T→H [n = 988]; arm...
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Clinical outcomes of carbon‐ion radiotherapy for patients with locoregionally recurrent nasopharyngeal carcinoma: BackgroundReirradiation for locoregionally recurrent nasopharyngeal carcinoma (LR‐NPC) after high‐dose radiotherapy (RT) is challenging and usually is associated with poor survival and severe toxicities. Because of its physical and biological advantages over photon‐beam RT, carbon‐ion RT (CIRT) could be a potential treatment option for patients with LR‐NPC.MethodsPatients with LR‐NPC...
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Association between postoperative complications and long‐term oncologic outcomes following total laryngectomy: 10‐year experience at MD Anderson Cancer Center: BackgroundPostoperative complications are an independent predictor of poor survival across several tumors. However, there is limited literature on the association between postoperative morbidity and long‐term survival following total laryngectomy (TL) for cancer.MethodsWe conducted a retrospective review of all TL patients at a single institution...
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Hyperthermic intraperitoneal chemotherapy in interval debulking surgery for advanced epithelial ovarian cancer: A single‐center, real‐life experience: BackgroundAn improvement in survival without increasing perioperative morbidity in patients with advanced epithelial ovarian cancer treated with hyperthermic intraperitoneal chemotherapy (HIPEC) after interval debulking surgery (IDS) has been recently demonstrated in a randomized controlled trial. This study was aimed at assessing the feasibility and...
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An in vitro study of the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma: AbstractBackgroundThe primary aim of this study was to observe the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma in vitro. MethodsSCC25 cells were divided into the observation group and the blank control group. Different concentrations of 5-ALA and SCC25 cells were co-incubated for different times, and the concentration of protoporphyrin IX...
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Early fiberoptic endoscopic evaluation of swallow in transoral robotic surgery: Description of swallow function and recovery in the acute postoperative period for oropharyngeal squamous cell carcinoma: AbstractBackgroundTransoral robotic surgery (TORS) is a minimally invasive approach for the treatment of oropharyngeal cancer. The effects on swallowing and speech need to be comprehensively evaluated to understand the associated morbidity.MethodsA prospective cohort of 21 patients was recruited to...
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Transoral robotic parapharyngeal approach to the submandibular space: AbstractThe aim of the study was to demonstrate a novel transoral parapharyngeal approach to the submandibular space. The method used was the clinical case of a patient presenting with an anteriorly based tumor in the left submandibular space. The video shows the transoral robotic technique for access to the submandibular space through the parapharyngeal space for removal of the tumor. This approach allows for high definition visibility...
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Population‐based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma: AbstractBackgroundMinimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC).MethodsThe Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease‐specific survival (DSS).ResultsOf the 325 patients with SNAC identified, 5‐year and 10‐year...
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Pediatric Rigid Bronchoscopy for Tracheobronchial Foreign Bodies in Covid Times: Short Personal Experience: AbstractThis case series of 5 patients of rigid bronchoscopy done for tracheobronchial foreign bodies is presented to readers to share my experience of doing rigid bronchoscopy during Covid Times from March to July 2020 specifically sharing experience on personal protection with local innovations during the procedure. Indications, intra-procedure modifications and other relevant things are...
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Intraindividual Consistency of Iodine Concentration in Dual-Energy Computed Tomography of the Chest and Abdomen: Objectives Dual-energy computed tomography (DECT)–derived quantification of iodine concentration (IC) is increasingly used in oncologic imaging to characterize lesions and evaluate treatment response. However, only limited data are available on intraindividual consistency of IC and its variation. This study investigates the longitudinal reproducibility of IC in organs, vessels, and...
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A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity: The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is increasingly associated with various neurological diseases. To gain a better understanding of the underlying processes involved in BBB breakdown, magnetic resonance imaging (MRI) techniques are highly suitable for noninvasive BBB assessment. Commonly...
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Fusion of Preinterventional MR Imaging With Liver Perfusion CT After RFA of Hepatocellular Carcinoma: Early Quantitative Prediction of Local Recurrence: Objectives The aim of this study was to evaluate the ability of fusion of pretreatment magnetic resonance (MR) imaging with posttreatment perfusion–CT (P-CT) after radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs) and to determine treatment success in an objective, quantitative way. Materials and Methods In this institutional...
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CT Dosimetry: What Has Been Achieved and What Remains to Be Done: Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose characterization, discuss their strengths and limitations, and present patient dose assessment methods. Computed tomography...
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A Magnetic Resonance Imaging Radiomics Signature to Distinguish Benign From Malignant Orbital Lesions: Objectives Distinguishing benign from malignant orbital lesions remains challenging both clinically and with imaging, leading to risky biopsies. The objective was to differentiate benign from malignant orbital lesions using radiomics on 3 T magnetic resonance imaging (MRI) examinations. Materials and Methods This institutional review board–approved prospective single-center study enrolled...
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Left heart bypass versus circulatory arrest for open repair of thoracoabdominal aortic pathologies: Our meta‐analysis found equivalent outcomes between left heart bypass and hypothermic circulatory arrest for open repair of thoracic aortic and thoracoabdominal aortic pathologies. Clinical outcomes evaluated were 30‐day mortality, post‐operative stroke, spinal cord deficit, renal failure and respiratory failure. AbstractBackgroundMost large‐volume centres use left heart bypass (LHB) as their preferred...
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Systematic review of perioperative mortality risk prediction models for adults undergoing inpatient non‐cardiac surgery: Risk prediction tools can be used in the perioperative setting to identify high‐risk patients who may benefit from increased surveillance and monitoring in the postoperative period, to aid shared decision‐making, and to benchmark risk‐adjusted hospital performance. We evaluated perioperative risk prediction tools relevant to an Australian context. AbstractBackgroundRisk prediction...
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Gene signatures from scRNA‐seq accurately quantify mast cells in biopsies in asthma: AbstractRespiratory disease, characterized by changes in the cells of the lung, can affect molecular phenotype of cells and the intercellular interactions, resulting in a disbalance in the relative proportions of individual cell types. Understanding these changes is essential to understand the pathophysiology of lung disease. Conventional 'bulk' RNA‐sequencing (RNA‐seq), analyzing the entire transcriptome of the...
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High Prevalence and Conservative Management of Acute Cholecystitis during Lenvatinib for Advanced Thyroid Cancer: Introduction: Lenvatinib (LEN) is a multitarget tyrosine kinase inhibitor currently used for advanced, radioiodine refractory differentiated thyroid cancer (RAI-R DTC). Among adverse events (AEs), nausea, vomiting, and decreased appetite have been frequently described. We aimed to evaluate the prevalence, the clinical presentation, and the effectiveness of conservative treatment of gallbladder...
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Low Diagnostic Yield of Repeat Blood Cultures in Adult Hematologic Malignancy Patients with Persistent Neutropenic Fever: AbstractFever complicates chemotherapy‐induced neutropenia in >80% of patients with hematologic malignancies. Microbiologically documented infections occur in 22%–39% of febrile episodes; common sites of tissue‐based infection include the intestinal tract, lung, and skin. Bacteremia is established in 18% of patients on fluoroquinolone prophylaxis versus 34% of patients not...
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Biallelic intronic AAGGG expansion of RFC1 is related to multiple system atrophy: ObjectiveA recessive biallelic repeat expansion, (AAGGG)exp, in the RFC1 gene has been reported to be a frequent cause of late‐onset ataxia. For cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS), the recessive biallelic (AAGGG)exp genotype was present in approximately 92% of cases. This study aimed to examine whether the pentanucleotide repeat (PNR) was related to multiple system atrophy (MSA)...
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Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function [NEW RESULTS]: Background: The emergence of a novel coronavirus (SARS-CoV-2) associated with severe acute respiratory disease (COVID-19) has prompted efforts to understand the genetic basis for its unique characteristics and its jump from non-primate hosts to humans. Tests for positive selection can identify apparently nonrandom patterns of mutation accumulation within genomes, highlighting...
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IJERPH, Vol. 17, Pages 6768: High-Performance Ha...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,