Rituximab in adult minimal change disease and focal segmental glomerulosclerosis - What is known and what is still unknown?: Publication date: Available online 15 September 2020Source: Autoimmunity ReviewsAuthor(s): Philipp Gauckler, Jae Il Shin, Federico Alberici, Vincent Audard, Annette Bruchfeld, Martin Busch, Chee Kay Cheung, Matija Crnogorac, Elisa Delbarba, Kathrin Eller, Stanislas Faguer, Kresimir Galesic, Siân Griffin, Zdenka Hrušková, Anushya Jeyabalan, Alexandre Karras, Catherine King,...
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The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzleAuthor links open overlay panelGuillermo CarvajalAlegriaabSaraBoukhlalacDiviCornecabValérieDevauchelle-PensecabaUniv Brest, Inserm, CHU de Brest, LBAI, UMR1227, Brest, FrancebService de Rhumatologie, Centre de Référence Maladies Autoimmunes Rares CERAINO, CHU Cavale Blanche, Brest, FrancecService de Médecine Interne, Pneumologie, Médecine Vasculaire, CHU Cavale Blanche, Brest, FranceReceived 17 April 2020, Accepted 23 April...
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Mucosal vitamin D signaling in inflammatory bowel disease: Publication date: Available online 15 September 2020Source: Autoimmunity ReviewsAuthor(s): Lauge Kellermann, Kim Bak Jensen, Fredrik Bergenheim, John Gubatan, Naomi D. Chou, Alan Moss, Ole Haagen NielsenAuthor links open overlay panelLaugeKellermannaKim BakJensenbcFredrikBergenheimaJohnGubatandNaomi D.ChoueAlanMossfOle HaagenNielsenaaDepartment of Gastroenterology, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, DenmarkbBiotech...
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New insight into the role of exosomes in vitiligo: Publication date: Available online 15 September 2020Source: Autoimmunity ReviewsAuthor(s): Pui Mun Wong, Lili Yang, Lingli Yang, Huali Wu, Wen Li, Xin Ma, Ichiro Katayama, Huimin ZhangAuthor links open overlay panelPui MunWonga1LiliYanga1LingliYangb1HualiWucWenLiaXinMaaIchiroKatayamabHuiminZhangaaDepartment of Dermatology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, 201203...
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Cognitive Functional Therapy (CFT) compared with Core Training Exercise (CTE) in patients with Failed Back Surgery Syndrome (FBSS): a study protocol for a randomized controlled trial.: Publication date: Available online 14 September 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Leonardo Avila, Marcos Lisboa Neves, André Rogério Abreu, Cibelle Ramos Fiuza, Leandro Fukusawa, Ney Meziat-Filho, Adair Roberto Soares SantosFailed back surgery syndrome (also called FBSS, or failed back...
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Bedeutung von CI-Nutzungsverhalten und CI-Anpassung für sprachproduktive Leistungen sehr früh cochleaimplantierter Kinder: ZusammenfassungHintergrundDas Alter bei Versorgung mit einem Cochleaimplantat (CI) nimmt bei Kindern wesentlich Einfluss auf deren Lautsprachentwicklung. Als weitere potenzielle Einflussfaktoren sollten das CI-Nutzungsverhalten und die Häufigkeit der CI-Anpassungen evaluiert sowie die frühkindlichen sprachproduktiven Leistungen sehr früh CI-versorgter Kinder dargestellt werden....
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[Allogeneic hematopoietic stem cell transplant in children and adults with sickle cell disease: Indications and modalities].: [Allogeneic hematopoietic stem cell transplant in children and adults with sickle cell disease: Indications and modalities].Bull Cancer. 2020 Sep 10;:Authors: Dhédin N, Paillard C, Dalle JH, Ouachée M, Buchbinder N, Brissot E, Beguin Y, Masouridi-Levrat S, Yakoub-Agha I, Bernit E, Pondarre CAbstract Sickle cell disease is associated with severe complications and...
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Wireless EEG for Fast Prep and Easy Use: Q&A with Aswin Gunasekar, CEO of Zeto: Electroencephalography (EEG) devices are incredibly helpful in diagnosing and monitoring certain brain disorders, such as epilepsy and strokes. However, they are not particularly user-friendly or convenient, with specialized technicians performing time consuming procedures, such as skin preparation, to get patients ready to undergo the procedure. A combination of messy gels and wires also makes for an uncomfortable...
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Breast radiologic complete response is associated with favorable survival outcomes after neoadjuvant chemotherapy in breast cancer: Publication date: Available online 14 September 2020Source: European Journal of Surgical OncologyAuthor(s): Jinsun Woo, Jai Min Ryu, Sung Mi Jung, Hee Jun Choi, Se Kyung Lee, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Byung Joo ChaeAbstractBackgroundThe aim of this study was to examine the accuracy of radiologic complete response (rCR) in predicting pathologic...
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Motor performance and back pain in children and adolescents: a systematic review and meta-analysis protocol: AbstractBackgroundThe relationship between motor performance and back pain in children and adolescents remains unclear. This article describes the protocol for a systematic review to summarize the knowledge about the association between motor performance, such as agility, flexibility, balance, strength, muscle endurance, and cardiorespiratory fitness, and back pain. Thus, our aim is to identify...
09:39
Loneliness in pregnant and postpartum people and parents of children aged 5 years or younger: a scoping review protocol: AbstractBackgroundThe experience of loneliness during pregnancy and in new parenthood has not been targeted and developed as a program of research, despite evidence indicating that the incidence of loneliness is highest in those aged 16 to 24 and that loneliness rises during transitional periods. The scarcity of parenthood-loneliness inquiries leaves a gap in our understanding...
09:38
Bactericidal In Vitro Activity of a Tissue-Achievable Concentration of Cefazolin against Methicillin-Resistant Staphylococcus aureus: Surgical Infections, Ahead of Print. AbstractBackground: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of skin and soft tissue infections and their recurrences. Although traditionally not considered for use against MRSA, cefazolin presents a possible option when administered using ultrasonic drug dispersion (UD2). This novel technique localizes...
09:35
Segmental Bone Reconstruction by Octacalcium Phosphate Collagen Composites with Teriparatide: Tissue Engineering Part A, Ahead of Print. AbstractOctacalcium phosphate and collagen composite (OCPcol) demonstrated superior bone regeneration and has been commercialized recently in Japan. Teriparatide (TPTD) is a bioactive recombinant form of parathyroid hormone that is approved for osteoporosis treatment. Because mandibular bone reconstruction after segmental resection is a key clinical problem, it...
09:34
Metformin Reduces Thyroid Cancer Tumor Growth in the Metastatic Niche of Bone by Inhibiting Osteoblastic RANKL Productions: Thyroid, Ahead of Print. AbstractBackground: Metformin has antitumoral actions in human cancers, including the thyroid, while its effects on metastatic lesions are unclear. Patients with bone metastasis (BM) from thyroid cancers have poor survival. Because metformin inhibits the activation of osteoclasts, which has essential roles in BM, the aim of this study was to investigate...
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Acute Renal Failure after Abdominal Trauma: Renal Artery Spasm Hypothesis in Ischemic Infarction in a 12-Year-Old Girl: Posttraumatic renal failure is often due to postischemic renal infarction, caused by identified vascular lesions. In our patient, a 12-year-old girl with acute anuric renal failure requiring hemodialysis after severe abdominal trauma, no vascular lesion or thrombosis was identified. Nevertheless, CT-scan and renal biopsy showed typical lesions of diffuse bilateral renal ischemic...
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The evolution of phenotypic plasticity in response to temperature stress [NEW RESULTS]: Phenotypic plasticity is the ability of a single genotype to produce different phenotypes in response to environmental variation. The importance of phenotypic plasticity in natural populations and its contribution to phenotypic evolution during rapid environmental change is widely debated. Here, we show that thermal plasticity of gene expression in natural populations is a key component of its adaptation: evolution...
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OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming: OVOL proteins (OVOL1 and OVOL2), vertebrate homologs of Drosophila OVO, are critical regulators of epithelial lineage determination and differentiation during embryonic development in tissues such as kidney, skin, mammary epithelia, and testis. OVOL can inhibit epithelial-mesenchymal transition and/or can promote mesenchymal-epithelial transition. Moreover, they can regulate the stemness of cancer cells, thus...
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Training in a cooperative bimanual skilled reaching task, the popcorn retrieval task, improves unimanual function after motor cortical infarcts in rats: Publication date: Available online 14 September 2020Source: Behavioural Brain ResearchAuthor(s): Anthony M. Dutcher, Khangy V. Truong, Dallas D. Miller, Rachel P. Allred, Evan Nudi, Theresa A. JonesHighlights•Rats learned a novel cooperative bimanual reaching skill after motor cortical infarcts.•Bimanual performance was with compensatory reliance...
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A Systematic Review of Cognitive Event-Related Potentials in Mild Cognitive Impairment and Alzheimer's Disease: Publication date: Available online 15 September 2020Source: Behavioural Brain ResearchAuthor(s): Elizabeth R. Paitel, Marielle R. Samii, Kristy A. Nielson•We systematically reviewed cognitive ERPs in MCI, AD, and intact APOE ε4-carriers.•Decreased ERP amplitude & delayed latency were associated with AD-related pathology.•The few existing studies of intact APOE ε4-carriers suggest compensatory...
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Covid-19 Demographics from a Tertiary Care Center: Does It Depreciate Quality-of-Life?: AbstractNovel Coronavirus-disease-2019 (Covid-19) caused by the severe-acute-respiratory-syndrome coronavirus-2 (SARS-CoV-2) shows a rapid spread all over the world. It's still an ongoing pandemic with greater morbidity and mortality. In our study, we describe clinical features, and demographics of patients presenting to our tertiary care center with Covid–19 infection. Global burden was...
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Robust Cardiac Regeneration: Fulfilling the Promise of Cardiac Cell Therapy: Publication date: Available online 14 September 2020Source: Clinical TherapeuticsAuthor(s): Dinesh Selvakumar, Zoe E. Clayton, James J.H. ChongAbstractPurposeWe review the history of cardiac cell therapy, highlighting lessons learned from initial adult stem cell (ASC) clinical trials. We present pluripotent stem cell–derived cardiomyocytes (PSC-CMs) as a leading candidate for robust regeneration of infarcted myocardium but...
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[ASAP] Hierarchically Porous S/N Codoped Carbon Nanozymes with Enhanced Peroxidase-like Activity for Total Antioxidant Capacity Biosensing: AbstractDesign of highly active carbon nanozymes and further establishment of ultrasensitive biosensors remain a challenge. Herein, hierarchically porous carbon nanozymes with sulfur (S)/nitrogen (N) codoping (SNC) were developed. Compared with N-doped carbon (NC) nanozymes, SNC nanozymes have a smaller Michaelis–Menten constant and higher specific activities,...
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[ASAP] Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes: AbstractThe subset of the proteome that contains enzymes in their catalytically active form can be interrogated by using probes targeted toward individual specific enzymes. A subset of such enzymes are proteases that are frequently studied with activity-based probes, small inhibitors equipped with a detectable tag, commonly a fluorophore. Due to the spectral overlap of these commonly used fluorophores,...
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[ASAP] Customized Chiral Colloids: Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07315
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The Child & Youth CompreHensIve Longitudinal Database for Deep Brain Stimulation (CHILD-DBS): AbstractPurposeDeep brain stimulation (DBS) is a common tool for the treatment of movement disorders in adults; however, it remains an emerging treatment modality in children with a growing number of indications, including epilepsy and dystonia. The Child & Youth CompreHensIve Longitudinal Database of DBS (CHILD-DBS) study aims to prospectively collect relevant data on quality of life (QoL), safety,...
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Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome: AbstractBackgroundThe recent emergence of COVID-19 poses a global health emergency. One of the most frequently reported data is sex-related severity and mortality: according to the last available analysis on 239,709 patients in Italy, lethality is 17.7% in men and 10.8% in women, with 59% of total deaths being men. Interestingly, the infection rate is lower in males than in females, with 45.8% and 54.2%...
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Semioccluded Vocal Tract Exercises Improve Self-Perceived Voice Quality in Healthy Actors: SummaryPurposeSemi-occluded vocal tract exercises (SOVTE) have shown to lead to more effective and efficient vocal production for individuals with voice disorders and for singers. The aim of the present study is to investigate the effects of a 10-minute SOVTE warm-up protocol on the actors' voice.MethodsTwenty-seven professional theater actors (16 females) without voice complaints were audio-recorded...
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Comparing extended versus standard time window for thrombectomy: caseload, patient characteristics, treatment rates and outcomes—a prospective single-centre study: AbstractPurposeNew guidelines recommend thrombectomy up to 24 h in selected patients; however, the workload and benefit of extending time window are not known. We conducted a prospective single-centre study to determine the caseload, imaging and interventional need of extended time window. MethodsAll consecutive ischemic...
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Aplastic anemia and COVID-19: how to break the vicious circuit?: Aplastic anemia and COVID-19: how to break the vicious circuit?Am J Blood Res. 2020;10(4):60-67Authors: Khaled SA, Hafez AAAbstract Aplastic anemia (AA) is a type of anemia that is caused by an intrinsic defect of hematopoietic progenitors or an extrinsic immune mediated destruction of stem cells. Patients commonly presented with pancytopenia, particularly leukopenia that renders patient susceptible to various infections....
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Analysis of outcomes in hospitalized pregnant patients with acute myeloid leukemia.: Analysis of outcomes in hospitalized pregnant patients with acute myeloid leukemia.Am J Blood Res. 2020;10(4):68-75Authors: Patel SJ, Ajebo G, Kota V, Guddati AKAbstract BACKGROUND: There have been significant advances in the management of acute myeloid leukemia (AML) in the past decade. However, management of AML in the pregnant patient has been challenging as most interventions are contraindicated in...
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A nationwide analysis of outcomes of stroke in hospitalized patients with essential thrombocythemia: 2006 to 2014.: A nationwide analysis of outcomes of stroke in hospitalized patients with essential thrombocythemia: 2006 to 2014.Am J Blood Res. 2020;10(4):76-81Authors: Ajebo G, Patel SJ, Kota V, Guddati AKAbstract BACKGROUND: Essential thrombocythemia (ET) is a subtype of myeloproliferative neoplasm associated with an increased risk of thrombohemorrhagic complications such as stroke. However,...
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Improved outcome in early induction deaths in patients with acute promyelocytic leukemia after therapeutic and supportive interventions: a follow up study of seven-years' experience at a tertiary care center.: Improved outcome in early induction deaths in patients with acute promyelocytic leukemia after therapeutic and supportive interventions: a follow up study of seven-years' experience at a tertiary care center.Am J Blood Res. 2020;10(4):82-89Authors: Shaikh MU, Ali N, Karim F, Raheem A, Sarwar...
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Regulatory T cells in pediatric AML are associated with disease load and their serial assessment suggests role in leukemogenesis.: Regulatory T cells in pediatric AML are associated with disease load and their serial assessment suggests role in leukemogenesis.Am J Blood Res. 2020;10(4):90-96Authors: Bansal AK, Sharawat SK, Gupta R, Vishnubhatla S, Dhawan D, Bakhshi SAbstract BACKGROUND: Regulatory T cells (Tregs) modulate immune system by suppressing other immune cells. In current exploratory...
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Prognostic impact of tumor-associated macrophages, lymphocyte-to-monocyte and neutrophil-to-lymphocyte ratio in diffuse large B-cell lymphoma.: Prognostic impact of tumor-associated macrophages, lymphocyte-to-monocyte and neutrophil-to-lymphocyte ratio in diffuse large B-cell lymphoma.Am J Blood Res. 2020;10(4):97-108Authors: Cencini E, Fabbri A, Schiattone L, Sicuranza A, Mecacci B, Granai M, Mancini V, Lazzi S, Bocchia M, Leoncini LAbstract INTRODUCTION: Microenvironment has a prognostic...
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Prognostic significance of CD56 and CD7 in acute myeloid leukaemia and their outcome.: Prognostic significance of CD56 and CD7 in acute myeloid leukaemia and their outcome.Am J Blood Res. 2020;10(4):109-117Authors: Rai S, Singh S, Gupta RAbstract BACKGROUND: The expression of CD7 and CD56 in Acute Myeloid Leukaemia was considered to be a poor prognostic factor for overall survival, complete remission but the result were limited and more prognostic parameter need to study. The importance...
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TAB3 overexpression promotes NF-κB activation and inflammation in acute pancreatitis.: TAB3 overexpression promotes NF-κB activation and inflammation in acute pancreatitis.Am J Blood Res. 2020;10(4):118-123Authors: Gao L, Zhao H, Sun H, Huang YAbstract Acute pancreatitis (AP) is a clinically common inflammatory disease, NF-κB activation and the secretion of pro-inflammatory mediators have been considered as the main events of AP. According to reports, TAB3 is essential for NF-κB activation...
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Outcomes of patients with relapsed or refractory acute myeloid leukemia: a population-based real-world study.: Outcomes of patients with relapsed or refractory acute myeloid leukemia: a population-based real-world study.Am J Blood Res. 2020;10(4):124-133Authors: Brandwein JM, Saini L, Geddes MN, Yusuf D, Liu F, Schwann K, Billawala A, Westcott C, Kurniawan JA, Cheung WYAbstract With standard therapies for patients with acute myeloid leukemia (AML), many patients either do not achieve complete...
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Next generation sequencing guided treatment modulation and prognosis in Acute myeloid leukemia: Case vignettes.: Next generation sequencing guided treatment modulation and prognosis in Acute myeloid leukemia: Case vignettes.Am J Blood Res. 2020;10(4):134-144Authors: Jain G, Thakral D, Sahoo RK, Kumar I, Vashishtha S, Verma P, Gupta RAbstract OBJECTIVE: The genomic mutational landscape of Acute Myeloid Leukemia has contributed to better treatment options, risk stratification and prognostication...
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Viruses play critical role in evolution and survival of the species:As the world scrambles to control the growing COVID-19 coronavirus pandemic, new research in Nature Structural & Molecular Biology shows viruses also play a key evolutionary role in mammals' ability to reproduce and survive.Scientists in the Cincinnati Children's Perinatal Institute and at Azabu University in Japan obtained their data by studying laboratory mice and human germline cells.In two separate papers appearing in the...
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Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis: Objective. To investigate the relationship between serum interleukin-2 (IL-2) levels and disease activity, absolute numbers of peripheral lymphocyte subsets, autoantibodies, and associated cytokines in patients with rheumatoid arthritis (RA). Methods. This study included 106 patients with RA, evaluated their disease activity (DAS28 score), and...
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Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy: detailsAbstractMolecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational principle of cell evolution, metabolism and pathology. Hypoxia-inducible factor (HIF) mediates tumour cells to produce a series of glucose metabolism adaptations including...
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Hsa_circ_0001944 promotes the growth and metastasis in bladder cancer cells by acting as a competitive endogenous RNA for miR-548: Bladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC; thus, the roles of circRNAs in this process have attracted signific... AbstractBackgroundBladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC;...
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Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark: AbstractNatural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modifications. NATs are dysregulated in various types of cancer, and an increasing number of studies focusing on NATs as pivotal regulators of the hallmarks of cancer and as promising...
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Stereotactic body radiotherapy versus conventional/moderate fractionated radiation therapy with androgen deprivation therapy for unfavorable risk prostate cancer: AbstractBackgroundUltrahypofractionation using stereotactic body radiotherapy (SBRT) is an increasingly utilized technique for men with prostate cancer (PC). The comparative efficacy of SBRT plus androgen deprivation therapy (ADT) compared to fractionated radiotherapy (EBRT) plus ADT in higher-risk prostate cancer is unknown.MethodsMen...
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Application of dose-volume histogram prediction in biologically related models for nasopharyngeal carcinomas treatment planning: AbstractPurposeIn this study, we employed a gated recurrent unit (GRU)-based recurrent neural network (RNN) using dosimetric information induced by individual beam to predict the dose-volume histogram (DVH) and investigated the feasibility and usefulness of this method in biologically related models for nasopharyngeal carcinomas (NPC) treatment planning.Methods and materialsOne...
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Liver Expressed Antimicrobial Peptide 2 is Associated with Steatosis in Mice and Humans: Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1210-2357Background and Aims Liver expressed antimicrobial peptide 2 (LEAP2) is recently identified as a regulator in energy metabolism. This study aims to 1) investigate the role of leap2 in hepatic steatosis in C57BL/6 mice; 2) evaluate the association between circulating LEAP2 levels...
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Clinical and Genetic Characteristics of 23 Korean Patients with Haploinsufficiency of the Short-stature Homeobox-containing Gene: Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1247-4863Background The short-stature homeobox-containing gene (SHOX) is one of the major growth genes in humans. The clinical spectrum of SHOX haploinsufficiency ranges from Léri–Weill dyschondrosteosis to idiopathic short stature. Herein, we...
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Novel urinary protein biomarker panel for early diagnosis of gastric cancer: AbstractBackgroundWith the goal of discovering non-invasive biomarkers for early diagnosis of GC, we conducted a case-control study utilising urine samples from individuals with predominantly early GC vs. healthy control (HC).MethodsAmong urine samples from 372 patients, age- and sex-matched 282 patients were randomly divided into three groups: 18 patients in a discovery cohort; 176 patients in a training cohort and 88 patients...
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A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy: The mortality in nonischaemic dilated cardiomyopathy (NIDCM) patients is still at a high level; sudden death in NIDCM can be caused by ventricular tachycardia. It is necessary to explore the pathogenesis of ventricular arrhythmias (VA) in NIDCM. Differentially expressed genes (DEGs) were identified by comparing the gene expression of NIDCM patients with or without VA in the...
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Skull fractures in abusive head trauma: a single centre experience and review of the literature: AbstractPurposeThe authors provide a comprehensive framework with which to approach paediatric calvarial injury sustained as a result of suspected abusive head trauma (AHT). This is achieved through the presentation of a case series set in the context of the unique morphology of the infant skull and the possible diagnostic pitfalls which may arise due to the presence of variant anatomy or other mimicking...
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GPR120 promotes radiation resistance in esophageal cancer via regulating AKT and apoptosis pathway: Objective The aim of the study is to investigate the role of GPR120 on the biological behavior of esophageal cancer cells in the setting of radiation and explore the mechanism. Methods GPR120 knockdown was fulfilled by siRNA-mediated effects in two esophageal cancer cell lines Eca109 and EC9706. Colony formation, survival fraction calculation, viable cell evaluation by cell counting kit-8...
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Abiraterone acetate and acute leukemia: a casual association?: We present the case of a 70-year-old patient affected by metastatic castration-resistant prostate cancer. He underwent radical prostatectomy in 2007 and subsequent adjuvant radiotherapy and hormonal therapy for 2 years. In 2011, he developed bilateral lung metastases, and therefore he received chemotherapy (eight cycles of docetaxel 75 mg/sqm every 3 weeks) with partial remission; rechallenge with the same drug was performed 7 months...
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Inhibition of melanoma by survivin-specific lymphocytes combined with CCL17 and granulocyte-macrophage colony-stimulating factor in a mouse syngeneic model: As a new generation of treatment, tumor immunotherapy targeting tumor-associated antigens (TAA) has attracted widespread attention. The survivin antigen belongs to TAA. It is a key inhibitor of apoptosis and a key regulator of cell cycle progression; furthermore, it may be a candidate target for tumor therapy. In addition, studies have confirmed...
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Upregulated long noncoding RNAs LINC02163 and FEZF1-AS1 exert oncogenic roles in colorectal cancer: A growing number of evidence has revealed that aberrantly expressed long noncoding RNAs (lncRNAs) are involved in the development of a variety of malignancies, including colorectal cancer (CRC). However, the clinical relevance of most lncRNAs and their potential biological functions in CRC remains poorly understood. The aim of this study was to identify the key lncRNAs related to patient prognosis...
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Induction chemotherapy in nonlaryngeal human papilloma virus-negative high-risk head and neck cancer: a real-world experience: AbstractObjectiveThe role of induction chemotherapy in the multidisciplinary treatment of locally advanced, nonlaryngeal high-risk human papilloma virus (HPV)-negative head and neck squamous cells carcinoma (HNSCC) is uncertain in terms of overall survival (OS). The primary objective of this study was to identify possible predictive factors of survival and outcome...
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A comparison of regularized logistic regression and random forest machine learning models for daytime diagnosis of obstructive sleep apnea: AbstractA major challenge in big and high-dimensional data analysis is related to the classification and prediction of the variables of interest by characterizing the relationships between the characteristic factors and predictors. This study aims to assess the utility of two important machine-learning techniques to classify subjects with obstructive sleep apnea...
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Automated glaucoma screening method based on image segmentation and feature extraction: AbstractGlaucoma is a chronic disease that threatens eye health and can cause permanent blindness. Since there is no cure for glaucoma, early screening and detection are crucial for the prevention of glaucoma. Therefore, a novel method for automatic glaucoma screening that combines clinical measurement features with image-based features is proposed in this paper. To accurately extract clinical measurement features,...
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Estimation of the effects of inset heights and slit configurations in an acetabular cup on the pull-out behavior of an artificial hip joint with a structure for preventing dislocation using finite element analysis: AbstractJoint dislocation is a critical problem of total hip replacement. We have newly proposed an artificial hip joint with a structure that prevents dislocation. The proposed joint has a simple form with a femoral head partially covered with an acetabular cup. In the present study,...
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Modelling force-length-activation relationships of wrist and finger extensor muscles: AbstractThe wrist and finger extensors play a crucial role in the muscle coordination during grasping tasks. Nevertheless, few data are available regarding their force-generating capacities. The objective of this study was to provide a model of the force-length-activation relationships of the hand extensors using non-invasive methods. The extensor carpi radialis (ECR) and the extensor digitorum communis (EDC) were...
08:31
Radiotheranostic Agent 64Cu-cyclam-RAFT-c(-RGDfK-)4 for Management of Peritoneal Metastasis in Ovarian Cancer: Purpose: Ovarian cancer peritoneal metastases (OCPMs) are a pathophysiologically heterogeneous group of tumors that are rarely curable. αVβ3 Integrin (αVβ3) is overexpressed on tumoral neovessels and frequently on ovarian cancer cells. Here, using two clinically relevant αVβ3-positive OCPM mouse models, we studied the theranostic potential of an αVβ3-specific radiopeptide, 64Cu-cyclam-RAFT-c(-RGDfK-)4...
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TSPO-targeted PET and Optical Probes for the Detection and Localization of Pre-Malignant and Malignant Pancreatic Lesions: Purpose: Pancreatic cancer is among the most aggressive malignancies and is rarely discovered early. However, pancreatic 'incidentalomas', particularly cysts, are frequently identified in asymptomatic patients through anatomical imaging for unrelated causes. Accurate determination of the malignant potential of cystic lesions could lead to life-saving surgery or spare patients...
08:29
Chloroquine sensitizes GNAQ/11-mutated melanoma to MEK1/2 inhibition: Purpose: Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in >90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAP kinase and YAP. To date, chemo- or pathway-targeted therapies, either alone or in combination, have proven ineffective in the treatment of metastatic uveal melanoma patients. Experimental Design: We tested the efficacy of chloroquine or hydroxychloroquine, in combination...
08:29
Helicobacter pylori Infection of the Gastric Mucosa and Ocular Adnexa—Lack of Association With Ocular Adnexal Lymphoma: Purpose: Helicobacter pylori could theoretically induce ocular adnexal lymphoma (OAL) via 2 mechanisms: the first is that of infection within the ocular adnexa and the second is that of infection within the gastric mucosa, leading to the malignant transformation of lymphocytes that migrate to the ocular adnexa, forming a primary "ectopic" cancer. This study investigated if...
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Orbital Osteomas: Report of 3 Rapidly Progressive Cases in Adolescents and Systematic Literature Review: Purpose: The purpose of this study was to describe the clinical characteristics, management, and outcomes of orbital osteomas in the pediatric age group, and compare these to osteomas managed in the adult population. Methods: A retrospective review of 3 cases of rapidly progressive orbital osteomas in young patients was performed. In addition, a systematic review of the literature...
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Simultaneous Orbital and Intracranial Abscesses in 17 Cases: Purpose: To describe the demographics, clinical presentation, treatment, and outcomes of a rare cohort with simultaneous orbital and intracranial abscesses. Methods: A historical cohort study of 17 patients with simultaneous orbital and intracranial abscesses between 2010 and 2018 was performed. The demographics, location of abscesses, treatment, and outcomes of these patients were analyzed. Results: The mean age...
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(+)-[ 18 F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer's disease and healthy controls: AbstractPurposesWe present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[18F]Flubatine. Aims were to develop a kinetic modeling-based approach to quantify (+)-[18F]Flubatine and compare the data of healthy...
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Characteristics of Laryngeal Osteosarcoma: A Critical Review.: Related ArticlesCharacteristics of Laryngeal Osteosarcoma: A Critical Review.Oncol Ther. 2020 Jun;8(1):33-44Authors: Mäkitie AA, Devaney KO, Baujat B, Almangush A, Ferlito AAbstract Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a lack of information on the characteristics...
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International Journal of Molecular SciencesIJMS...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,