Journal of AnatomyOntogeny and homology of cranial bones associated with lateral‐line canals of the Senegal Bichir, Polypterus senegalus (Actinopterygii: Cladistii: Polypteriformes), with a discussion on the formation of lateral‐line canal bones in fishesWe describe the development of bones associated with lateral‐line canals in the Senegal Bichir and use these data to re‐address previous hypotheses of homology of skull bones of polypterids. We demonstrate that the lateral‐line canals comprise a...
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COVID‐19 indirect contact transmission through the oral mucosa must not be ignored: AbstractBackgroundCoronavirus (CoV) is the single stranded sense RNA virus that has been known so far with the largest genomic capacity and plenty of natural hosts. In the past dozens of years, SARS‐CoV under the branch of the new evolutionary tree has threatens greatly global public health and the severe acute respiratory syndrome new coronavirus (COVID‐19) reported in China could cause fatal pathological lesions....
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Value of colchicine as treatment for recurrent oral ulcers: a systematic review: AbstractBackgroundin oral medicine, colchicine is a therapeutic alternative for idiopathic recurrent aphthous stomatitis (RAS), Behçet disease (BD), Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome, and Mouth and Genitals Ulcers with Inflamed Cartilage (MAGIC) syndrome. The present review aims to evaluate reliability of colchicine against recurrent oral ulcers.MethodsA systematic...
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Association between cancer‐specific adverse event triggers and mortality: A validation studyIn a retrospective longitudinal cohort of 322 887 newly diagnosed patients with breast, colorectal, lung, or prostate cancer, there was increased one‐year mortality among patients who experienced oncology‐specific claims‐based triggers compared to patients without triggers. Increased mortality was observed across all cancer types, stratified by metastatic status, in unadjusted and multivariate analyses. Abstract...
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Olfactory dysfunction from acute upper respiratory infections: relationship to season of onsetBackground Acute viral upper respiratory tract infections are the most common cause of chronic olfactory dysfunction. In light of the seasonality of numerous viruses, the question arises as to whether the frequency and magnitude of postviral olfactory disorders (PVODs) are similarly seasonal. We sought to determine whether olfactory deficits due to influenza and non–influenza‐related viruses (I‐PVODs and...
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Australasian Journal of DermatologyAngiolymphoid hyperplasia with eosinophilia of the tongue with a Sézary syndrome history: Evidence for immune mediation of the diseaseAustralasian Journal of Dermatology22hProfound pearly penile papulesAustralasian Journal of Dermatology22hTildrakizumab in the treatment of PASH syndrome: A potential novel therapeutic targetAustralasian Journal of Dermatology22hKeratinocyte cancer with incidental perineural invasion: A registry analysis of management and 5‐year...
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Latest Results for Oral and Maxillofacial SurgeryFull-staged digital and prosthetic guided protocol for the insertion of dental implants in autogenous free bone grafts after reconstruction of segmental mandibular defectsAbstract Purpose This study aims to evaluate the clinical and radiographic outcomes of dental implants, inserted in consolidated free bone grafts; postsegmental mandibular resection, after following a fully guided staged protocol, which established a systematic approach that correlates...
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Exploding head syndrome, chronotype, parasomnias and mental health in young adults: AbstractAlthough inadequate sleep among young people is well documented in the literature, anomalous sleep experiences, such as the parasomnia termed exploding head syndrome (EHS), have received little empirical attention. The current study examined the association of sleep quality, symptoms of psychological distress and other unusual sleep experiences with EHS in a sample of young adults (n = 135, age M = 21.77,...
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Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages: Airway epithelial cells and macrophages participate in inflammatory responses to external noxious stimuli, which can cause epithelial injury. Upon injury, epithelial cells and macrophages act in concert to ensure rapid restoration of epithelial integrity. The nature of the interactions between these cell types during epithelial repair is incompletely understood. We used an in vitro human coculture...
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Bone Marrow Langerhans Cell Histiocytosis in Association with Kasabach-Merritt Syndrome: The Difficulty of a Differential Diagnosis: Langerhans cell histiocytosis is a rare haematological disorder with variable clinical findings and a high mortality rate. On the other hand, Kasabach-Merritt syndrome is of rare onset at adult age, requiring the simultaneous presentation of vascular lesion, thrombocytopenia, and consumptive coagulopathy. We present the first reported case of both diseases in a single...
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pubmed: sleepStudy of knowledge, attitude, anxiety & perceived mental healthcare need in Indian population during COVID-19 pandemic.Related ArticlesStudy of knowledge, attitude, anxiety & perceived mental healthcare need in Indian population during COVID-19 pandemic. Asian J Psychiatr. 2020 Apr 08;51:102083 Authors: Roy D, Tripathy S, Kar SK, Sharma N, Verma SK, Kaushal V Abstract Novel Corona Virus Disease (COVID-19) originating from China has rapidly crossed borders, infecting people throughout...
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The rs11187533 C>T Variant of the <b><i>FFAR4</i></b> Gene Is Associated with Lower Levels of Fasting Glucose and Decreases in Markers of Liver Injury in Children with Obesity: Introduction: Genetic factors can modulate the development of associated comorbidities in obesity. It has been shown that loss-of-function variants of the free fatty acid receptor 4 (FFAR4) gene negatively affect obesity comorbidities such as insulin resistance and fatty liver disease. Objective:...
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Latest Results for Chinese Journal of Integrative MedicineMAO Ze-dong's View on Traditional Chinese Medicine and Its Modern SignificanceAbstract MAO Ze-dong's view on traditional Chinese medicine (TCM) can be divided into the scientific view on TCM, the development view on TCM and the future view on TCM. The core of MAO Ze-dong's view on TCM lies in its scientific nature. The basic content of MAO Ze-dong's development view on TCM includes unity of TCM and Western medicine (WM), advocating the multi-angle...
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Angiolymphoid hyperplasia with eosinophilia of the tongue with a Sézary syndrome history: Evidence for immune mediation of the disease.: Related ArticlesAngiolymphoid hyperplasia with eosinophilia of the tongue with a Sézary syndrome history: Evidence for immune mediation of the disease.Australas J Dermatol. 2020 Apr 13;:Authors: Lin SF, Wei YM, Fan Y, Sun CFPMID: 32281101 [PubMed - as supplied by publisher]
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Microcystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature.: Microcystic adnexal carcinoma (MAC) is a rare, malignant appendage tumor commonly classified as a low-grade sweat gland carcinoma that typically occurs on the head and neck, particularly the central face. Microcystic adnexal carcinoma shows aggressive local invasion with rare reports of lymph node metastases.Feb 20, 2019Microcystic Adnexal Carcinoma: Practice Essentials ...Related...
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Verrucous hyperplasia and verrucous carcinoma in head and neck: use and benefit of methotrexate.: Related ArticlesVerrucous hyperplasia and verrucous carcinoma in head and neck: use and benefit of methotrexate.Acta Clin Belg. 2020 Apr 11;:1-5Authors: De Keukeleire S, De Meulenaere A, Deron P, Huvenne W, Fréderic D, Bouckenooghe O, Ferdinande L, Creytens D, Rottey SAbstract Background and aim: Verrucous hyperplasia (VH) and verrucous carcinoma (VC) of the head and neck are two (pre)malignant...
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An Unusual Case of Noisy Breathing in an Infant.: Related ArticlesAn Unusual Case of Noisy Breathing in an Infant.J Clin Sleep Med. 2019 01 15;15(1):149-152Authors: Leon-Astudillo C, Lee GS, Katwa UAbstract ABSTRACT: Laryngomalacia is a common cause of chronic noisy breathing that can present as stridor in infants and neonates. Mild cases of laryngomalacia are usually followed clinically and managed conservatively. However, the evaluation and diagnosis could be challenging in some patients....
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The role of polysomnography in decannulation of children with brain and spinal cord injuries.: Related ArticlesThe role of polysomnography in decannulation of children with brain and spinal cord injuries.Pediatr Pulmonol. 2019 03;54(3):333-341Authors: Morrow AK, Tunkel DE, Collaco JM, McGrath-Morrow SA, Lam JC, Accardo JA, Rybczynski SVAbstract OBJECTIVE: The objective of this retrospective review was to determine the utility of polysomnography (PSG) in influencing the decision to decannulate...
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Periodontitis is associated with incident chronic liver disease-A population-based cohort study.: Related ArticlesPeriodontitis is associated with incident chronic liver disease-A population-based cohort study.Liver Int. 2019 03;39(3):583-591Authors: Helenius-Hietala J, Suominen AL, Ruokonen H, Knuuttila M, Puukka P, Jula A, Meurman JH, Åberg FAbstract BACKGROUND & AIMS: Chronic liver disease is a major health concern worldwide and the identification of novel modifiable risk factors...
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AA pubmed: head and neckGeneration of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration.Related ArticlesGeneration of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration. Biomaterials. 2020 Apr 02;248:119995 Authors: Kim E, Wu F, Wu X, Choo HJ Abstract Craniofacial skeletal muscle is composed of approximately 60 muscles, which have critical functions including...
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Bloody Diarrhea in a 17-year-old Male: A 17-year-old African American male presented to the emergency department complaining of 5 days of diarrhea, which was watery and intermittently bloody. He had engaged in his first act of condomless receptive anal intercourse 2 months prior. Additionally, he reported a diagnosis of "strep throat" 1 week before this presentation but did not receive antimicrobial treatment. Vital signs were within normal limits, and the patient was afebrile upon presentation,...
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pubmed: philosophy for medic...Condom use philosophy and behaviors among young men who have sex with men: Variations among HIV pre-exposure prophylaxis users and nonusers.Related ArticlesCondom use philosophy and behaviors among young men who have sex with men: Variations among HIV pre-exposure prophylaxis users and nonusers. J Am Assoc Nurse Pract. 2020 Apr 08;: Authors: Fontenot HB, Krakower D, White BP, Marquez SM, Dormitzer J, Psaros C, OʼCleirigh C, Mayer KH Abstract BACKGROUND: In the United...
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Preoperative Factors Associated with Extrathyroidal Extension in Papillary Thyroid Cancer: Objective: Extrathyroidal extension may not be accurately recognized during thyroidectomy and can increase the risk of positive margins and even recurrence. This study aimed to investigate the preoperative factors associated with extrathyroidal extension. Methods: We analyzed 887 patients with papillary thyroid cancer (PTC) who underwent surgery in the period of 2005–2017. Binary logistic regression analyses...
09:28
MAO Ze-dong's View on Traditional Chinese Medicine and Its Modern SignificanceAbstract MAO Ze-dong's view on traditional Chinese medicine (TCM) can be divided into the scientific view on TCM, the development view on TCM and the future view on TCM. The core of MAO Ze-dong's view on TCM lies in its scientific nature. The basic content of MAO Ze-dong's development view on TCM includes unity of TCM and Western medicine (WM), advocating the multi-angle development of TCM from the height of Chinese national...
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Vaccination of Mice with <b><i>Listeria ivanovii</i></b> Expressing the Truncated M Protein of Porcine Reproductive and Respiratory Syndrome Virus Induces both Antigen-Specific CD4+ and CD8+ T Cell-Mediated Immunity: Porcine reproductive and respiratory syndrome (PRRS), a serious disease of swine caused by the PRRS virus (PRRSV), had a severe economic impact worldwide. As commonly used PRRS vaccines, the attenuated or inactivated vaccines, provide unsatisfactory immune protection,...
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Management of epistaxis in patients on novel oral anticoagulation therapy.: Related ArticlesManagement of epistaxis in patients on novel oral anticoagulation therapy.J Laryngol Otol. 2020 Apr 13;:1-7Authors: Ho JPK, Bari N, Riffat FAbstractBACKGROUND: Individuals on anticoagulation therapy are at increased risk of bleeding, including epistaxis. There is a lack of available reversal agents for novel oral anticoagulation therapy.OBJECTIVE: This paper reviews the current literature on epistaxis in...
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BRC : Last 10 articlesThe Usefulness of the Pretreatment Neutrophil/Lymphocyte Ratio as a Predictor of the 5-Year Survival in Stage 1–3 Triple Negative Breast Cancer PatientsBackground: We have previously shown that the neutrophil/lymphocyte ratio (NLR) is a predictor of survival among breast cancer patients. The aim of this study was to determine the predictive value of NLR among different nodal and chemotherapy subgroups of triple negative breast cancer (TNBC). Methods: Patients with stage 1–3...
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pubmed: "oral oncol"[jour]Induction versus adjuvant chemotherapy combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: A propensity score-matched analysis.Related ArticlesInduction versus adjuvant chemotherapy combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: A propensity score-matched analysis. Oral Oncol. 2020 Apr 10;105:104686 Authors: Tang SQ, Xu C, Wang XS, Tang LL, Li WF, Chen L, Mao YP, Guo R, Liu Q, Sun...
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Antibiotics, Vol. 9, Pages 180: Polyphasic Validation of a Nisin-Biogel to Control Canine Periodontal DiseaseAntibiotics, Vol. 9, Pages 180: Polyphasic Validation of a Nisin-Biogel to Control Canine Periodontal Disease Antibiotics doi: 10.3390/antibiotics9040180 Authors: Cunha Freitas Braz Silva Tavares Veiga Oliveira Background: Periodontal disease (PD) is a highly prevalent inflammatory disease in dogs. This disease is initiated by a polymicrobial biofilm on the teeth surface, whose control includes...
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JPM, Vol. 10, Pages 23: A Global Review on the Utility of Genetic Testing for Familial Hypercholesterolemia: JPM, Vol. 10, Pages 23: A Global Review on the Utility of Genetic Testing for Familial HypercholesterolemiaJournal of Personalized Medicine doi: 10.3390/jpm10020023Authors: Rachele M. Hendricks-Sturrup Jodi Clark-LoCascio Christine Y. Lu Familial hypercholesterolemia (FH) is a genetic disorder of cholesterol metabolism that affects an estimated 1/250 persons in the United States and...
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310 nm UV-LED Attenuates Imiquimod-Induced Psoriasis-like Skin Lesions in C57BL/6 Mice and Inhibits IL-22-Induced STAT3 Expression in HaCaT Cells: Photochem. Photobiol. Sci., 2020, Accepted ManuscriptDOI: 10.1039/C9PP00444K, PaperTae-Rin Kwon, Sung-Eun Lee, Jong-Hwan Kim, Yu Na Jang, Su-Young Kim, Seok Kyun Mun, Chan Woong Kim, Jungtae Na, Beom Joon KimUltraviolet light-emitting diodes (UV-LEDs) are a novel light source for phototherapy. This study aimed to evaluate the therapeutic effects of UV-LEDs...
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Online First ArticlesGolgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast CancerThe metabolic network of sphingolipids plays important roles in cancer biology. Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate multiple aspects of growth, apoptosis, and cellular signaling. Although a significant number of enzymatic regulators of the sphingolipid pathway have been described in detail, many remained poorly characterized. Here we applied a patient-derived...
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Nonsurgical Treatments for Extramammary Paget Disease: A Systematic Review and Meta-Analysis: Introduction: Surgery is commonly regarded as the mainstay of treatment of extramammary Paget disease (EMPD); however, nonsurgical approaches have gained popularity in recent years. Objectives: To review the published evidence for the efficacy and safety of nonsurgical modes of therapy for EMPD. Methods: A systematic review and meta-analysis of nonsurgical EMPD treatments was performed. The primary outcome...
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20 σπάνια γυναίκεια ονόματα και η σημασία τους: Δεν έχετε καταλήξει ακόμα στο όνομα που θα δώσετε στο κοριτσάκι σας; Η παράδοση θέλει τα ονόματα να περνάνε από γενιά σε γενιά και από τον παππού και τη γιαγιά στα εγγόνια έχει υπάρχει ακόμα και στις μέρες μας. Αν όμως εσείς θέλετε να πρωτοτυπήσετε, μπορείτε να επιλέξετε κάποιο από τα πιο ασυνήθιστα ελληνικά ή […]1. Άλκηστις: η δύναμη του σπιτιού και της οικογένειας είναι η ακριβής σημασία του ονόματος -και όχι άδικα, αφού η κόρη σας είναι η ψυχή της...
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Latest Results for Der ChirurgMehr Hemithyroidektomien in den USA beim Schilddrüsenkarzinom nach Publikation der ATA-LeitlinienLatest Results for Der Chirurg15hTherapie kolorektaler und nichtkolorektaler Lebermetastasen: Sinnhaftigkeit neoadjuvanter TherapiekonzepteZusammenfassung Hintergrund Lebermetastasen stellen die häufigste sekundär maligne Erkrankung der Leber dar. Zahlen zur Inzidenz kolorektaler und nichtkolorektaler Lebermetastasen lassen sich aufgrund mangelnder Erfassung in Registern...
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*Journal* of *Medical Internet Research*Internet Hospitals Help Prevent and Control the Epidemic of COVID-19 in China: Multicenter User Profiling Study*Journal* of *Medical Internet Research*15hThe Buffering Effect of Health Care Provider Video Biographies When Viewed in Combination With Negative Reviews: "You Can't Fake Nice"*Journal* of *Medical Internet Research*15hExploring the Factors Influencing Consumers to Voluntarily Reward Free Health Service Contributors in Online Health Communities:...
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Explaining Parkinsonian Postural Sway Variabilities Using Intermittent Control Theory: Publication date: Available online 13 April 2020Source: Journal of BiomechanicsAuthor(s): Ranjita Dash, Vrutangkumar V. Shah, Harish J. Palanthandalam-Madapusi
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GeneRegulation of growth-related genes by nutrition in paralarvae of the common octopus (<em>Octopus vulgaris</em>)Publication date: Available online 13 April 2020Source: GeneAuthor(s): D. Garcia de la serrana, M. Pérez, M. Nande, J. Hernández-Urcera, E. Pérez, C. Coll-Lladó, C. HollenbeckGene14hMachine learning identifies 10 feature miRNAs for Lung squamous cell carcinomaPublication date: Available online 13 April 2020Source: GeneAuthor(s): Zheng Ye, Bo Sun, Zhongdang XiaoGene14hMark...
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Comparison of ATG-thymoglobulin with ATG-Fresenius for Epstein-Barr virus infections and graft-versus-host-disease in patients with hematological malignances after haploidentical hematopoietic stem cell transplantation: a single-center experience: AbstractTwo anti-thymocyte globulin (ATG) forms are used in graft-versus-host disease (GVHD) prophylaxis during haploidentical hematopoietic stem cell transplantations (haplo-HSCTs): ATG-thymoglobulin (ATG-T) and ATG-fresenious (ATG-F). However, comparable...
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ScienceDirect Publication: Changing for a Better FuturePublication date: 13 April 2020Source: Cancer Cell, Volume 37, Issue 4Author(s): Steve MaoScienceDirect Publication: Cancer Cell14hIntegrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade GliomasPublication date: 13 April 2020Source: Cancer Cell, Volume 37, Issue 4Author(s): Scott Ryall, Michal Zapotocky, Kohei Fukuoka, Liana Nobre, Ana Guerreiro Stucklin, Julie Bennett, Robert Siddaway, Christopher Li, Sanja Pajovic, Anthony...
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AUD : Last 20 articlesEpidemiology and Seasonal Variation of Ménière's Disease: Data from a Population-Based StudyIntroduction: Ménière's disease (MD) is a disease of the inner ear. In Asian countries, there is one previous epidemiologic study that used a retrospective survey of a specific district. Previous studies have demonstrated that weather variables are strongly associated with symptom aggravation in MD. However, no study has reported on seasonal variation of MD. Methods: We conducted a retrospective...
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Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole: Introduction: Peptic lesions usually develop when there is an imbalance between aggressive drivers and gastro-protective mediators that guard the lining of the gastrointestinal tract. The most crucial of these mediators are antioxidants, whose loss may predispose to oxidative stress, which is believed to be the main aggravator of several diseases including peptic...
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Pathological and molecular detection of a rare case of cutaneous cryptococcosis in a 9-year-old horse: AbstractThis report describes a rare case of primary cutaneous cryptococcosis in equines. A young gelding horse was presented with facial masses showing ulcerations and yellowish discharge. Histopathological examination of biopsy specimens showed a dermal granulomatous reaction containing neutrophils, macrophages, and giant cells. In addition, numerous spherical yeast-like organisms were clearly...
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CancersCancers, Vol. 12, Pages 972: Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer TherapyCancers, Vol. 12, Pages 972: Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy Cancers doi: 10.3390/cancers12040972 Authors: Naveen Singh S. Louise Pay Snehal B. Bhandare Udhaya Arimpur Edward A. Motea Poly-(ADP-ribose) polymerase 1 (PARP1) is commonly known for its vital role in DNA damage response and repair. However, its enzymatic...
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Single median maxillary central incisor syndrome and variant in SMO gene associated with SHH pathway
Single median maxillary central incisor syndrome and variant in SMO gene associated with SHH pathway: Publication date: Available online 13 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Tomasz Zatoński, Pazdro-Zastawny Katarzyna, Morawska-Kochman Monika, Biela Mateusz, Kołtowska Anna, Rydzanicz Małgorzata, Rozensztrauch Anna, Joanna Kosińska, Dorobisz Karolina, Płoski Rafał, Robert ŚmigielCase ReportSingle median maxillary central incisor syndrome and variant...
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Diagnosis and management of pediatric cerebrospinal fluid leakage secondary to inner ear malformations: a report of 13 cases: Publication date: Available online 13 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Wenmin Deng, Jie Liu, Feng Pang, Xiangmin ZhangDiagnosis and management of pediatric cerebrospinal fluid leakage secondary to inner ear malformations: a report of 13 casesAuthor links open overlay panelWenminDengJieLiuFengPangXiangminZhangDepartment of Sleep...
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Characterizing Emerging Canine H3 Influenza Viruses: by Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S. Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L. DeDiego, Brian R. Wasik, Benjamin L. Miller, Carole Henry, Patrick C. Wilson, Mark Y. Sangster, John J. Treanor, David J. Topham, Lauren Byrd-Leotis, David A. Steinhauer, Richard D. Cummings, Jasmina M. Luczo, Stephen M. Tompkins, Kaori Sakamoto,...
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Retraction for Li et al., Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging [Retractions]MEDICAL SCIENCES Retraction for "Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging," by Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai...Proceedings of the National Academy...
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Nocturnal swallowing augments arousal intensity and arousal tachycardia [Neuroscience]: Cortical arousal from sleep is associated with autonomic activation and acute increases in heart rate. Arousals vary considerably in their frequency, intensity/duration, and physiological effects. Sleep and arousability impact health acutely (daytime cognitive function) and long-term (cardiovascular outcomes). Yet factors that modify the arousal intensity and autonomic activity remain enigmatic....
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Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage [Neuroscience]: In the adult brain, vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilities. Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke-induced damage caused by toxic extrasynaptic NMDA receptor (eNMDAR) signaling. Here we show that stimulation of eNMDARs causes a...
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Hepatocellular Carcinoma Score and Subclassification Into Aggressive Subtypes Using Immunohistochemical Expression of p53, β-Catenin, CD133, and Ki-67: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy in adults. Several studies have classified HCC into molecular subtypes aiming at detecting aggressive subtypes. The aim of the present study was to investigate the role of p53, β-catenin, CD133, and Ki-67 in subclassification of HCC into different aggressive subtypes and...
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Comparison of the Lymph2Cx Assay and Hans Algorithm in Determining the Cell-of-Origin of Diffuse Large B-Cell Lymphomas, Not Otherwise Specified: In the era of precision medicine, accurate and reproducible assignment of cell-of-origin (COO) in diffuse large B-cell lymphoma patients has become important. The Lymph2Cx assay is accurately determining COO by analyzing RNA expression of 20 selected genes while the Hans algorithm based on immunohistochemistry is the most popular method for routine daily...
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Third Order Neuron In Auditory Pathway To Brain: neuro exam 3 auditory system. STUDY. PLAY. What nerve is associated with the ...Third Order Neuron In Auditory Pathway To BrainHomeGamesPortfolioBlogInfoSearch Third Order Neuron In Auditory Pathway To BrainThe final neuron of the primary auditory pathway links the thalamus to the auditory cortex, where the message, already largely decoded during its passage through the previous neurons in the pathway, is recognized, memorized and perhaps integrated...
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The Primary Auditory Cortex Receives Information From All Senses: Know your brain: Primary somatosensory cortex. The Auditory System - Explorable.com; What area of ...The Primary Auditory Cortex Receives Information From All SensesFunctional Systems of the Cerebral Cortex. Sensory Areas.. For example, the right primary somatosensory cortex receives information from the left limbs,. primary auditIakahhoyfae Duckdns OrgThe Central Nervous System, Chapter 12 Flashcards | QuizletAuditory system - WikipediaFunctional...
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Anesthesia considerations of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: a case series: AbstractPurposeEssential tremor (ET) is a common movement disorder with disability in voluntary actions such as eating and writing. First-line treatment involves pharmacological agents, although efficacy is limited by side effects. In these patients, functional neurosurgery can be considered. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) thalamotomy offers...
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The videoscopic view may not be significantly superior to the directly sighted peroral view during Macintosh-style videolaryngoscopy: a randomized equivalence cadaver trial: AbstractPurposeVideolaryngoscopy is widely believed to give a superior view to that obtained by direct laryngoscopy. Published literature suggests this benefit extends to both hyper-angulated and Macintosh-style videolaryngoscopes. Notwithstanding, our clinical experience shows that the videoscopic view with a Macintosh-style...
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A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug–Drug Interactions of Bortezomib: AbstractBortezomib is a potent 20S proteasome inhibitor approved for the treatment of multiple myeloma and mantle cell lymphoma. Despite the extensive clinical use of bortezomib, the mechanism of the complex time-dependent pharmacokinetics of bortezomib has not been fully investigated in context of its pharmacodynamics (PD) and...
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Extraction, characterization and molecular structure of bovine skin gelatin extracted with plant enzymes bromelain and zingibain: AbstractBovine skin was incubated with plant enzymes bromelain (B) and zingibain (Z) at the level of 0, 5, 10, 15, 20 and 25 unit/g of skin and gelatin was extracted at 60 °C for 6 h. Control gelatin was extracted without enzymatic pretreatment. The yield and gel strength were 17.90% and 283.35 g for the control samples and 22.26% and 160.88 g for B20 samples. The zingibain...
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Central Neuropathic Mechanisms in Pain Signaling Pathways: Current Evidence and Recommendations: AbstractPurposeThis is a comprehensive review of the current literature on central neuropathic pain mechanisms that is secondary to spinal cord injury. It reviews recent and seminal findings on the pathophysiology, diagnosis, and treatment and compares treatment options and recommendations.Recent FindingsNeuropathic pain (NP) is a common complication of spinal cord injury (SCI). Chronicity of NP is attributed...
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Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics: AbstractMicrobiota are increasingly studied, providing more precise information on their important role in physiologic processes. They also influence some pathologic processes, such as NSAID-induced enteropathy. This side effect is much more diffuse than it has been described in the past. It derives mainly from the local action of the medicines and is caused by the local binding of gram-negative...
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Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema: AbstractThe aim of this was to develop a well-balanced, replaceable, and patient non-infringing innovative transdermal drug delivery system "nano-vesicle transdermal gel" (NVTG) approaches for inhibiting inflammation. To consummate this objective, we developed a skin permeation nanogel system containing surface active agent along with ethanol. Carbopol 971p, hydroxypropyl...
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Evaluation of circulating transcript analysis (NETest) in small intestinal neuroendocrine neoplasms after surgical resection: AbstractPurposeSurgical resection is the only effective curative strategy for small intestinal neuroendocrine neoplasms (SINENs). Nevertheless, the evaluation of residual disease and prediction of disease recurrence/progression remains a problematic issue.MethodsWe evaluated 13 SINENs that underwent surgical resection of the primary tumour and/or mesenteric mass. Patients...
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Comparison of different systems of ultrasound (US) risk stratification for malignancy in elderly patients with thyroid nodules. Real world experience: AbstractPurposeTo comparatively assess the performance of three sonographic classification systems, American Thyroid Association (ATA), the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS), and American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology (ACE)/Associazione Medici Endocrinologi...
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Effect of type 2 diabetes and antihyperglycemic drug therapy on signs of tumor invasion in papillary thyroid cancer: AbstractPurposeThis retrospective study investigated the association between worrisome pathological features of papillary thyroid cancer indicative of invasion and type 2 diabetes, as well as antihyperglycemic drug therapy for diabetes.MethodsThe records of 14,167 patients who had undergone primary surgery for thyroid cancer were retrospectively reviewed and screened for concomitant...
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Lipschütz's acute vulvar ulcer: a systematic review: AbstractIn previously healthy subjects, vulvar ulcers are mostly caused by sexually transmitted microorganisms. Lipschütz's acute vulvar ulceration, first reported in 1912, is a non-sexually acquired condition characterized by sudden onset of a few genital ulcers. We systematically review presentation, underlying causes, and disease duration of Lipschütz's ulceration. A comprehensive source of Excerpta Medica, National Library of Medicine, and...
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Association between thyroid function and serum cortisol in cortisol-producing adenoma patients: AbstractPurposeThyroid dysfunction has been reported in hypercortisolism. Previous findings regarding changes in thyroid function due to cortisol-producing adenoma (CPA) have been inconsistent. The study aimed to investigate the association between thyroid function and excessive cortisol secretion in patients with CPA and to explore the changes in pituitary function after adrenalectomy.MethodsWe conducted...
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Cognitive Impairment Correlates Linearly with Mean Flow Velocity by Transcranial Doppler below a Definable Threshold: Introduction: Low cerebral blood flow can affect cognition in patients with high-grade asymptomatic internal carotid artery stenosis. Current clinical algorithms use stroke risk to determine which patients should undergo revascularization without considering cognitive decline. Although correlations between low-flow and cognitive impairment have been reported, it is not known whether...
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Spontaneous Intraoperative Rupture of a Large Interstitial Pregnancy: Laparoscopic Management: We present a case of a large interstitial pregnancy which was intraoperatively ruptured, but was eventually laparoscopically treated. The patient experienced 9 weeks of amenorrhea, and a right cornual pregnancy measuring 6 cm was diagnosed. The patient consented on having a minimal surgical treatment, and a laparoscopic right cornuotomy was decided. During surgery, and prior to any manipulation to the uterus,...
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Novel Dimethylacetamide-Containing Formulation Improves Infraorbital Anaesthesia Efficacy in Rats with Periodontitis: Background. To evaluate acute toxicity and local anaesthetic activity of a formulation containing a novel dimethylacetamide derivative, antioxidant, and vasoconstrictor in rats with chronic periodontitis. Methods. Novel anaesthetic dimethylacetamide-containing formulation LHT-15-32 was studied as 2% water solution. Its acute intravenous and subcutaneous toxicity was determined in...
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Is Tumor-Free Distance an Independent Prognostic Factor for Early-Stage Endometrioid Endometrial Cancer?: There are many studies assessing the importance of myometrial invasion using a cut-off limit as 50% of myometrial invasion for endometrial cancer, and there are a limited number of studies evaluating tumor-free distance to the serosa. To evaluate the prognostic performance of tumor-free distance and percentage of myometrial invasion in patients with stage IB endometrioid endometrial cancer, we...
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A Part of the Medial Branch of the Deep Peroneal Nerve Distributes the Dorsal Pedis Artery and Its Distribution Area is Close to the Acupuncture Point LR3 (Taichong): Cutaneous nerves have vascular branches (VBs) that reach the arteries and are thought to be involved in arterial constriction. We aimed to examine the anatomical and histological relationship between the VBs of a cutaneous nerve in the foot and the acupuncture point LR3 (Taichong), which is a depression between the base of the first...
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Candida Empyema as a Red Flag for Esophageal Rupture: A Case Report and Literature Review: Background. Candida empyema is a rare entity with an extremely high mortality rate.We present a case of multi species Candida empyema in an immunocompetent female patient with Boerhaave syndrome secondary to retching and vomiting after heroin withdrawal. This case highlights an unusual presentation of a common infection but stresses on the fact that a high index of suspicion is necessary for early identification,...
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The Coexistence of Colorectal Polyps in the Right Colon Increases the Malignant Risk of Laterally Spreading Tumors: Background. The coexistence of colorectal polyps with laterally spreading tumors (LSTs) is commonly observed during colonoscopy. However, there are rare studies that assess the malignant risks for LSTs with colorectal polyps, which might largely contribute to further strategies of treatment and follow-up plans in LSTs. Methods. We conducted a retrospective cohort study that enrolled...
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The Number of Central Lymph Nodes on Preoperative Ultrasound Predicts Central Neck Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Cohort Study: To evaluate the effectiveness of the number of central compartment lymph nodes (CLNs) on ultrasound (US) in predicting CLN metastasis (CLNM). We prospectively studied 309 papillary thyroid cancer (PTC) patients who underwent thyroidectomy with CLN dissection at our center from May 2017 to July 2017. The number and features of CLNs were...
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Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules: Research Article | Open AccessVolume 2020 |Article ID 1749351 | 11 pages | https://doi.org/10.1155/2020/1749351Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign...
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Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer: Objective. To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers. Design and Methods. We retrospectively studied 98 subjects (83 women, 47 ± 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any...
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Facial Recognition for Drunk People Using Thermal Imaging: Face recognition using thermal imaging has the main advantage of being less affected by lighting conditions compared to images in the visible spectrum. However, there are factors such as the process of human thermoregulation that cause variations in the surface temperature of the face. These variations cause recognition systems to lose effectiveness. In particular, alcohol intake causes changes in the surface temperature of the face. It is...
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Comparison of Conventional Keratometry and Total Keratometry in Normal Eyes: Purpose. The relationship between conventional keratometry and total keratometry has not been fully investigated. This study was aimed at conventional keratometry measured with the automated keratometer and total keratometry with the corneal tomographer in ophthalmologically normal subjects. Methods. We enrolled fifty eyes of 50 consecutive subjects (,) who have no ophthalmologic diseases, other than refractive errors, with...
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Impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology Classification of Thyroid Nodules in the Treatment of Indeterminate Follicular Lesions: Five-Year Results at a Single Center: Purpose. Aim of the study was to assess the impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology (SIAPEC) classification of 2014, on the treatment of indeterminate thyroid lesions (TIR3). Methods. We retrospectively analyzed patients undergoing thyroid surgery for TIR3 lesions...
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Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis: Background. Helicobacter pylori is detected in various extragastric diseases, including biliary tract cancers. Besides, gallbladder cancers, extracholangiocarcinomas, and intracholangiocarcinomas are highly lethal cancers with limited survival due to their late diagnosis. Epidemiological data on Helicobacter pylori infection and biliary tract cancer have been contradictory. Aim. The aim of this study is to explore and evaluate the association...
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Spontaneous Spinal Epidural Hematoma in a Patient on Apixaban for Nonvalvular Atrial Fibrillation: Background. With the rise in the use of direct oral anticoagulants (DOACs), more hemorrhagic complications are being encountered. Since the first description of a case of spontaneous spinal epidural hematoma (SSEH) related to the utilization of DOACs in 2012, there have been few reports describing a similar association. However, no cases so far have reported an association between SSEHs and apixaban....
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Hereditary angioedema: the challenges of cross-border family investigation and treatment: Hereditary angioedema (HAE) is a rare genetic disorder characterised by recurrent swellings involving subcutaneous and submucosal tissue that can be potentially life threatening in cases involving the upper airway. In this case report, we present a Syrian refugee family with HAE who have lived in Denmark since 2014. The index patient is an 8-year-old girl diagnosed with HAE after being hospitalised in Denmark...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,