Annals of Plastic Surgery - Current IssueAtypical Lipomatous Tumors of the Extremities and Trunk Wall—The First Case Series of Chinese Population With 45 Cases: CorrigendumNo abstract availableAnnals of Plastic Surgery - Current Issue1mDickkopf 2–Expressing Adenovirus Increases the Survival of Random-Pattern Flaps and Promotes Vasculogenesis in a Rat ModelBackground Dickkopf 2 (DKK2) has important roles in vertebrate development; it inhibits Wnt signaling-related processes, such as axial patterning,...
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Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expressionHsa_circ_100338 was upregulated in piplartine treated hepatocellular carcinoma cells. Dual luciferase reporter gene assay and RIP assay showed that circ‐100338 can regulate ZEB1 expression by competitively bind to miR‐141‐3p. Abstract Researches have pointed that piplartine inhibits the proliferation of hepatocellular carcinoma (HCC) cells, however, the underlying mechanisms has not...
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pubmed: Dependency of the optical scattering properties of human milk on casein content and common sample preparation methods.Related ArticlesDependency of the optical scattering properties of human milk on casein content and common sample preparation methods. J Biomed Opt. 2020 Apr;25(4):1-12 Authors: Veenstra C, Every DE, Petersen W, van Goudoever JB, Steenbergen W, Bosschaart N Abstract SIGNIFICANCE: Quantifying human milk composition is important for daily nutritional management in neonatal...
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AA pubmed: Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms.Related ArticlesAssociation of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020 Apr 12;: Authors: Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS Abstract BACKGROUND: Rapid spread of the SARS-CoV-2 virus and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance...
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Assessing non-aggressiveness of untreated, local and regional, papillary thyroid cancer.: Related ArticlesAssessing non-aggressiveness of untreated, local and regional, papillary thyroid cancer.Oral Oncol. 2020 Apr 09;105:104674Authors: van Gerwen M, Alpert N, Sinclair C, Kale M, Genden E, Taioli EAbstract OBJECTIVES: With a steadily increasing thyroid cancer incidence, information regarding cancer aggressiveness is essential to determine which patients may be suitable for active surveillance....
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Chronic invasive fungal rhinosinusitis vs sinonasal squamous cell carcinoma: the differentiating value of MRI.: Related ArticlesChronic invasive fungal rhinosinusitis vs sinonasal squamous cell carcinoma: the differentiating value of MRI.Eur Radiol. 2020 Apr 11;:Authors: Li Z, Wang X, Jiang H, Qu X, Wang C, Chen X, Chong VF, Zhang L, Xian JAbstract OBJECTIVES: To investigate MRI features in discriminating chronic invasive fungal rhinosinusitis (CIFRS) from sinonasal squamous cell carcinomas...
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Epstein-Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country.: Related ArticlesEpstein-Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country.Int J Cancer. 2020 Apr 12;:Authors: Simon J, Schroeder L, Ingarfield K, Diehl S, Werner J, Brenner N, Liu Z, Pawlita M, Pring M, Butt J, Ness A, Waterboer TAbstract Epstein-Barr virus (EBV) causes nasopharyngeal...
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Lymphangioleiomyomatosis.: Related ArticlesLymphangioleiomyomatosis.Semin Respir Crit Care Med. 2020 Apr;41(2):256-268Authors: Xu KF, Xu W, Liu S, Yu J, Tian X, Yang Y, Wang ST, Zhang W, Feng R, Zhang TAbstract Lymphangioleiomyomatosis (LAM) is a slow albeit progressive rare neoplastic disease featured with diffuse thin-walled cysts in lungs and angiomyolipomas in kidneys. LAM affects almost exclusively women and has one of the strongest gender predispositions of any extragenital human disease....
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The Effect of Venlafaxine on Apnea Hypopnea Index in Patients with Sleep Apnea - a Randomized, Double-Blind Crossover Study.: Related ArticlesThe Effect of Venlafaxine on Apnea Hypopnea Index in Patients with Sleep Apnea - a Randomized, Double-Blind Crossover Study.Chest. 2020 Apr 09;:Authors: Schmickl CN, Li Y, Orr JE, Jen R, Sands SA, Edwards BA, DeYoung P, Owens RL, Malhotra AAbstract BACKGROUND: One of the key mechanisms underlying obstructive sleep apnea (OSA) is a reduced pharyngeal...
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pubmed: sleepBurden of Living with Multiple Concurrent Symptoms in Patients with End-stage Renal Disease.Related ArticlesBurden of Living with Multiple Concurrent Symptoms in Patients with End-stage Renal Disease. J Clin Nurs. 2020 Apr 11;: Authors: Ng MSN, Lee Wong C, Ho EHS, Hui YH, Miaskowski C, So WKW Abstract AIMS AND OBJECTIVES: To explore the experience of multiple concurrent symptoms over time and their impact on daily living in patients with end-stage renal disease undergoing dialysis....
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Overexpression of NuSAP1 is predictive of an unfavourable prognosis and promotes proliferation and invasion of triple-negative breast cancer cells via the Wnt/β-catenin/EMT signalling axis: Publication date: Available online 13 April 2020Source: GeneAuthor(s): Li Sun, Changlong Shi, Shaozhuang Liu, Enchong Zhang, Long Yan, Ce Ji, Yi Zhao
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Upfront autologous stem cell transplantation for untreated diffuse large B cell lymphoma patients in rituximab era: a systematic review and meta-analysis: AbstractTo assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Cochrane Library, and...
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edoc: No conditions. Results ordered -Date Deposited.5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in OncologyPhosphoinositide 3-kinase (PI3K) is deregulated in a wide variety of human tumors and triggers activation of protein kinase B (PKB/Akt) and mammalian target of rapamycin (mTOR). Here we describe the preclinical characterization of compound 1 (PQR309,...
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Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing: AbstractThe vascular endothelium is a protective barrier between the bloodstream and the vasculature that may be disrupted by different factors such as the presence of diseased states. Diseases like diabetes and obesity pose a great risk toward endothelial cell inflammation and oxidative stress, leading to endothelial cell dysfunction and thereby cardiovascular complications such as atherosclerosis. Sirtuins...
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Latest Results for Abdominal ImagingInter-observer variability of radiologists for Cambridge classification of chronic pancreatitis using CT and MRCP: results from a large multi-center studyAbstract Purpose Determine inter-observer variability among radiologists in assigning Cambridge Classification (CC) of chronic pancreatitis (CP) based on magnetic resonance imaging (MRI)/magnetic resonance cholangiopancreatography (MRCP) and contrast-enhanced CT (CECT). Methods Among 422 eligible subjects enrolled...
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Atypical Manifestation of DRESS Syndrome: The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. We present a case of transaminases over 1000 units/liter from an atypical etiology. A 52-year-old male, previously treated with allopurinol for an acute gout flare, presented with persistent fevers....
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Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele: Since autophagy was suspected to occur in the pathological situation of varicocele (VCL), we have attempted to confirm it here using a surgical model of varicocele-induced rats. Thirty Wistar rats were divided into three groups (varicocele/sham/control) and analyzed two months after the induction of varicocele. Testicular tissue sections and epididymal mature sperm were then monitored for classic features of varicocele,...
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Isolated Splenic Lymphangiomas Presenting in an Infant with Isolated Anaemia: Lymphangiomas are benign tumours of lymphatic vessels which are not linked with the normal lymphatic vessels. Their symptoms usually depend on their location and size as they can compress or block adjacent organs. We present a 9-month-old girl with isolated cavernous lymphangiomas of the spleen, a rare variable of lymphangiomas, with no symptoms. She had an isolated anaemia which could only be explained by the hypersplenism...
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Acute Portal Vein Thrombosis Treated with Recombinant Human Soluble Thrombomodulin Combined with Antithrombin III: Portal vein thrombosis is a major complication associated with liver cirrhosis. In cirrhotic patients, a decrease in procoagulant and anticoagulant factors and an unstable balance between them is observed, and a relative decrease in the activation of anticoagulant drivers is one of the main causes of portal vein thrombosis (PVT). Herein, we report a case of acute portal thrombosis associated...
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CD7-Positive Diffuse Large B-Cell Lymphoma Presenting as an Intranasal Tumor: We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because positron emission tomography-computed tomography after R-CHOP revealed an intranasal lesion. The patient achieved complete...
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RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer: Objective. RAS gene testing on tumor tissue biopsies is required for metastatic colorectal cancer (CRC) patients. However, it is infeasible for patients after curative surgery and repeated biopsy. This study is aimed at evaluating the consistency of RAS genes in patient's plasma, stool, and tumor tissue samples, to explore whether plasma and stool samples can supplement or replace tumor tissue to assess baseline...
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Pregnancy and Venous Thromboembolism: Risk Factors, Trends, Management, and Mortality: Background. Pregnancy is one of the major risk factors for the development of venous thromboembolism (VTE). Objective. To elucidate the circumstances surrounding pregnancy-induced deep vein thrombosis (DVT) and pulmonary embolism (PE), assess potential factors triggering thrombosis (e.g., thrombophilia, obesity, age, parity, and family history), initial and long-term management, and assess recurrence rate and mortality...
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Effect of Astragalus membranaceus Oral Solution on Lifespan and Learning and Memory Ability of Honey Bees: In this study, the effects of Astragalus membranaceus oral solution on lifespan and learning and memory abilities of honey bees were evaluated. Two groups of bees were fed with sucrose syrup (50%) containing low dose (1.33%) and high dose (13.3%) of A. membranaceus oral solution, respectively. The proboscis extension response (PER) analysis was applied to examine the learning and memory capabilities...
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Depression and Its Associated Factors among Diabetes Mellitus Patients Attending Selected Hospitals in Southwest Ethiopia: A Cross-Sectional Study: Background. Diabetes mellitus and depression are very common diseases worldwide, and the prevalence rates of both conditions are increasing rapidly. Depression among patients with diabetes mellitus results in poor glycemic control through different mechanisms. Besides, the coexistence of a chronic medical illness with depression reduces the probability...
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Hydrothermal Catalytic Conversion of Glucose into Lactic Acid with Acidic MIL-101(Fe): MIL-101(Fe) was explored for the first time for the catalytic conversion of glucose into lactic acid (LA). The as-synthesized MIL-101(Fe) was successfully characterized, and its higher specific surface area, porosity, and feasible acid properties were confirmed to determine the remarkable catalytic activity in glucose-to-LA conversion (up to 25.4% yield) compared with other catalysts like MIL-101(Cr, Al) and UiO-66(Zr)....
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Bacteriological Contamination of Drinking Water Supply from Protected Water Sources to Point of Use and Water Handling Practices among Beneficiary Households of Boloso Sore Woreda, Wolaita Zone, Ethiopia: The quality of drinking water is a powerful environmental determinant of health. Water becomes contaminated with faecal material due to inadequate protection of the source, unhygienic practices of the community at the source, and poor household handling practices. The objective of this study was...
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Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro: Astrocytes respond to central nervous system (CNS) insults with varieties of changes, such as cellular hypertrophy, migration, proliferation, scar formation, and upregulation of glial fibrillary acidic protein (GFAP) expression. While scar formation plays a very important role in wound healing and prevents further bleeding by forming a physical barrier, it is also one of key features of CNS...
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Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future: The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been...
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Comparison of Antimicrobial Resistance Detected in Environmental and Clinical Isolates from Historical Data for the US: Antimicrobial resistance (AMR) has become an urgent public health issue, as pathogens are becoming increasingly resistant to commonly used antimicrobials. While AMR isolate data are available in the NCBI Pathogen Detection Isolates Browser (NPDIB) database, few researches have been performed to compare antimicrobial resistance detected in environmental and clinical isolates. To...
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Association of Differing Qatari Genotypes with Vitamin D Metabolites: Objective. Genetic studies have identified four Qatari genotypes: Q1 Arab, Bedouin; Q2 Asian/Persian; Q3 African; and a fourth admixed group not fitting into the previous 3 groups. This study was undertaken to determine if there was an increased risk of deficiency of vitamin D and its metabolites associated with differing genotypes, perhaps due to genetic differences in skin pigmentation. Methods. 398 Qatari subjects (220 type...
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Modeling the Spatiotemporal Dynamics of Oncolytic Viruses and Radiotherapy as a Treatment for Cancer
Modeling the Spatiotemporal Dynamics of Oncolytic Viruses and Radiotherapy as a Treatment for Cancer: Virotherapy is a novel treatment for cancer, which may be delivered as a single agent or in combination with other therapies. Research studies indicated that the combination of viral therapy and radiation therapy has synergistic antitumor effects in in vitro and in vivo. In this paper, we proposed two models in the form of partial differential equations to investigate the spatiotemporal dynamics...
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Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects: Purpose. To explore the disease progression of primary open-angle glaucoma (POAG) in individuals with different degrees of VF defects by analyzing the trends in retinal nerve fiber layer (RNFL) changes at each stage. Methods. A total of 39 patients (77 eyes) were divided into three groups based on the severity of glaucomatous visual field (VF) loss: the first group included patients with mild...
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Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging: The present study explored the clinical value of plasma microRNA-21 as a novel biomarker for early prediction of stable and unstable angina patients and its relationship with aging. A total of 255 participants, 123 patients with chronic stable angina, 82 patients with unstable angina, and 50 healthy subjects, were included in our study. Stable coronary and unstable coronary patients were confirmed...
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The Response of the Pulp-Dentine Complex, PDL, and Bone to Three Calcium Silicate-Based Cements: A Histological Study in an Animal Rat Model: Objective. The aim of this study was to histologically examine the tissue reaction of three different calcium silicate cements in the closure of perforations in rat incisor teeth. Material and Methods. An experimental lateral root perforation with pulp exposure was performed in 32 lower incisors of 16 male Wistar albino rats. They were randomly assigned into...
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Efficacy of Pleuran (β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection: One of the highly prevalent viral pathogens among children and adults causing infection, clinically presenting as herpes labialis, is herpes simplex virus type 1 (HSV-1). The long-term administration of acyclovir, a standard regimen for therapy against HSV-1 infections, can cause viral resistance against this drug. Therefore, the development of natural drugs with low toxicity that are...
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Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?: Aim. We aimed to determine the alterations in macular and optic nerve vasculature in patients with migraine without aura using optical coherence tomography-angiography (OCTA). We also aimed to determine whether there were clinical differences and alterations in ocular structures in migraine cases with white matter hyperintensities (WMH) using magnetic resonance...
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TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways: Methamphetamine (METH) leads to nervous system toxicity. Long-term exposure to METH results in damage to dopamine neurons in the ventral tegmental area (VTA), and depression-like behavior is a clinical symptom of this toxicity. The current study was designed to investigate whether the antioxidant tertiary butylhydroquinone (TBHQ) can alleviate neurotoxicity through both antioxidative...
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3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome: Background. Obesity is a growing epidemic with limited effective treatments and an important risk factor for several diseases such as metabolic syndrome (MetS). In this study, we aimed to investigate the effect of 3-amino-1,2,4-triazole (ATZ), an inhibitor of catalase and heme synthesis, in a murine model for MetS. Methods. Male C57BL/6 mice with high-fat diet-induced MetS received ATZ (500 mg·kg-1·24 h-1)...
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An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism: Aim. The BDNF dysfunction in the schizophrenia has been soundly documented. The TrkB gene is a high-affinity receptor of the BDNF that is changed in schizophrenia and mood disorders. The study had two aims: first, to identify whether the five nucleotide polymorphisms (SNPs) in TrkB gene are associated with a diagnosis of schizophrenia; and the latter, if any association...
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E-Cigarette Quality Control: Impurity and Nicotine Level Analysis in Electronic Cigarette Refill Liquids: This work targets mainly the quality control of electronic cigarette liquids. It relies on an analytical control of a "32-product" sample made of several types of e-cigarette liquids taken from various supermarkets and tobacconist's offices in Morocco. All along this study, we made sure to check both the conformity of the nicotine level indicated in the packaging of each product and the existence...
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Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome: Background. The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to evaluate the prevalence of NAFLD, as diagnosed by ultrasound, in patients with acute coronary syndrome (ACS) and to assess whether NAFLD is associated with the severity of coronary obstruction as diagnosed by coronary angiography. Methods. We performed a prospective single-center...
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miR-21 and Pellino-1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency: Background. Premature ovarian insufficiency (POI) represents the hypergonadotropic hypoestrogenic symptoms that result in the loss of ovarian follicles. 5-30% POI cases are suggested to be involved in autoimmune etiology. MicroRNA-21 (miR-21) plays a vital role in ovarian folliculogenesis via regulating and interacting with multiple target genes. Here, we conduct the target prediction of miR-21, identify the...
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Durability of Esophageal Motor Disorders Identified on High-Resolution Esophageal Manometry: A Case Series: AbstractBackground/AimDiagnosis of esophageal motor disorders using high-resolution esophageal manometry (HREM) may result in medical, endoscopic or surgical intervention. However, prior to any intervention, durability of the HREM findings should be established. The aim of this case series was to assess 25 patients who had undergone HREM twice, at least 6 months apart, and to determine the...
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The Causes of Hypo- and Hyperphosphatemia in Humans: AbstractPhosphate homeostasis involves several major organs that are the skeleton, the intestine, the kidney, and parathyroid glands. Major regulators of phosphate homeostasis are parathormone, fibroblast growth factor 23, 1,25-dihydroxyvitamin D, which respond to variations of serum phosphate levels and act to increase or decrease intestinal absorption and renal tubular reabsorption, through the modulation of expression of transcellular transporters...
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Characterization of CD103 + CD8 + tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade: AbstractThough therapy that promotes anti-tumor response about CD8+ tumor-infiltrating lymphocytes (TILs) has shown great potential, clinical responses to CD8+ TILs immunotherapy vary considerably, largely because of different subpopulation of CD8+ TILs exhibiting different biological characters. To define the relationship between subpopulation...
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Relevance of humanized three-dimensional tumor tissue models: a descriptive systematic literature review: AbstractDespite numerous advances in tumor screening, diagnosis, and treatment, to date, tumors remain one of the leading causes of death, principally due to metastasis and the physiological damage produced by tumor growth. Among the main limits related to the study of tumor physiology there is the complex and heterogeneity nature of its environment and the absence of relevant, simple and inexpensive...
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Concomitant Congenital Intraoral Dermoid Cyst and Heterotopic Gastrointestinal Cyst: AbstractSublingual dermoid cysts and oral heterotopic gastrointestinal cysts are well-documented causes of sublingual swellings in infants. However, the simultaneous occurrence of both cysts is an extremely rare phenomenon, with only two previous cases reported in literature. We present a case of 1-month-old neonate with a cystic ventral tongue mass that on histologic examination showed a dermoid cyst with co-existing...
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Distribution of the CAG Triplet Repeat in ATXN1 , ATXN3 , and CACNA1A Loci in Peruvian Population: AbstractSpinocerebellar ataxia subtypes 1, 3, and 6 (SCA1, MJD/SCA3, and SCA6) are among the most prevalent autosomal dominant cerebellar ataxias worldwide, but their relative frequencies in Peru are low. Frequency of large normal (LN) alleles at spinocerebellar ataxia-causative genes has been proposed to be associated with disease prevalence. To investigate the allelic distribution of the CAG repeat...
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Upfront autologous stem cell transplantation for untreated diffuse large B cell lymphoma patients in rituximab era: a systematic review and meta-analysis: AbstractTo assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Cochrane Library, and...
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Reinke's edema: a proposal for a classification based on morphological characteristics: AbstractPurposeReinke's edema is a benign laryngeal condition characterized by swelling of the superficial layer of the lamina propria of the vocal fold. The aim of this work is to propose a new classification of Reinke's edema based on its morphological characteristics.MethodsOur classification is a synthesis of the classifications available in the literature and is based on morphological characteristics such...
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Double crosslinked HLC-CCS hydrogel tissue engineering scaffold for skin wound healing: Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): Jing Cao, Pan Wang, Yannan Liu, Chenhui Zhu, Daidi Fan
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Blend biopolymeric nanofibrous scaffolds of cellulose acetate/ε-polycaprolactone containing metallic nanoparticles prepared by laser ablation for wound disinfection applications: Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): M.K. Ahmed, A.A. Menazea, A.M. Abdelghany
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Camellia oil alleviates the progression of Alzheimer's disease in aluminum chloride-treated rats: Publication date: Available online 12 April 2020Source: Free Radical Biology and MedicineAuthor(s): Ming-Hung Weng, Sheng-Yi Chen, Zih-Ying Li, Gow-Chin Yen
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Monitoring the Crosstalk Between the Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 with PET: AbstractPurposeOvarian cancer (OC) leads to poor survival rates mainly due to late stage detection and innate or acquired resistance to chemotherapy. Thus, efforts have been made to exploit the estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) to treat OC. However, patients eventually become resistant to these treatments as well. HER2 overexpression contributes to...
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Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): This narrative review summarizes what is currently known about how SARS-CoV-2 infects cells and causes disease as a basis for considering whether chloroquine, remdisivir and other antivirals, or other existing drugs might be effective treatment for coronavirus disease 2019 (COVID-19).
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Noise-Induced Changes of the Auditory Brainstem Response to Speech—a Measure of Neural Desynchronisation?: AbstractIt is commonly assumed that difficulty in listening to speech in noise is at least partly due to deficits in neural temporal processing. Given that noise reduces the temporal fidelity of the auditory brainstem response (ABR) to speech, it has been suggested that the speech ABR may serve as an index of such neural deficits. However, the temporal fidelity of ABRs, to both speech and non-speech...
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Cancers, Vol. 12, Pages 961: Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic MalignanciesCancers, Vol. 12, Pages 961: Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies Cancers doi: 10.3390/cancers12040961 Authors: Vaishnavi Muralikrishnan Thomas D. Hurley Kenneth P. Nephew Gynecologic cancers cause over 600,000 deaths annually in women worldwide. The development of chemoresistance after initial rounds of chemotherapy contributes...
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Cancers, Vol. 12, Pages 964: SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications: Cancers, Vol. 12, Pages 964: SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic ImplicationsCancers doi: 10.3390/cancers12040964Authors: Sofia T. Menendez Veronica Rey Lucia Martinez-Cruzado M. Victoria Gonzalez Alvaro Morales-Molina Laura Santos Verónica...
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Cancers, Vol. 12, Pages 958: Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review: Cancers, Vol. 12, Pages 958: Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic ReviewCancers doi: 10.3390/cancers12040958Authors: Iléana Corbeau William Jacot Séverine Guiu Inflammatory blood markers (IBM), such as the neutrophil to lymphocyte ratio (NLR), have emerged as potential prognostic...
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Cancers, Vol. 12, Pages 963: Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease: Cancers, Vol. 12, Pages 963: Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's DiseaseCancers doi: 10.3390/cancers12040963Authors: Müge Yalçin Rukeia...
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Cancers, Vol. 12, Pages 961: Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies: Cancers, Vol. 12, Pages 961: Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic MalignanciesCancers doi: 10.3390/cancers12040961Authors: Vaishnavi Muralikrishnan Thomas D. Hurley Kenneth P. Nephew Gynecologic cancers cause over 600,000 deaths annually in women worldwide. The development of chemoresistance after initial rounds of chemotherapy...
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Predicting air quality of Dhaka and Sylhet divisions in Bangladesh: a time series modeling approachAbstract Air pollution has emerged as one of the major public health threats. In recent years, Bangladesh has ranked among top air polluted countries around the globe. Air quality in Bangladesh is measured on daily basis using national standards of five pollutants—NO2, CO, Ozone (O3), SO2, and particulate matter (PM2.5 and PM10) and presented as indexed value ranged from 0 to 500 which is further classified...
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Effect of fats and oils on pasting and textural properties of wheat flourAbstract Effects of fats and oils on pasting and textural properties of soft and hard wheat flours were investigated. Fats and oils significantly diminished peak viscosity, trough, breakdown, setback, final viscosity and escalated the pasting temperature. Effects on pasting properties were found more noticeable for soft wheat flour. Pasting properties of soft and hard wheat flour were significantly affected by coconut oil and...
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Effect of Thick-Needle Therapy in Patients with Bell's Palsy at Recovery Stage: A Multi-center Randomized Controlled Trial: AbstractObjective: To compare the clinical effects of thick-needle therapy (TNT) and acupuncture therapy (AT) on patients with Bell's palsy (BP) at the recovery stage. Methods: A total of 146 eligible participants from 3 hospitals in China were randomized into the TNT group (73 cases) and the AT group (73 cases) using a central randomization. Both groups received Western medicine...
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[ASAP] Heterojunction Perovskite Solar Cells: Opto-Electro-Thermal Physics, Modeling, and ExperimentACS NanoDOI: 10.1021/acsnano.0c01392ACS Nano: Latest Articles (ACS Publications)5h[ASAP] Giant Superelastic Piezoelectricity in Flexible Ferroelectric BaTiO<sub>3</sub> MembranesACS NanoDOI: 10.1021/acsnano.0c01615ACS Nano: Latest Articles (ACS Publications)5h[ASAP] Nonenzymatic Glucose Sensing Using Ni<sub>60</sub>Nb<sub>40</sub> NanoglassACS NanoDOI: 10.1021/acsnano.9b09778ACS...
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First Report on Concomitant Infection of Nasal Myiasis and Trichosporonosis in an Uncontrolled Diabetic Patient: Case Report: AbstractMyiasis is an infestation of living tissue of animals or humans by fly larvae. It is quite common in tropical countries due to hot and humid climates. Trichosporonosis is an invasive disseminated fungal infection caused by Trichosporon species. Disseminated trichosporonosis is usually a fatal disease with poor prognosis. The aim of this manuscript is to report a clinical...
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Chondrosarcoma in the Parapharyngeal Space; Site of Origin an Enigma: AbstractChondrosarcoma of the head and neck region is a rare disease, representing approximately 0.1% of all head and neck neoplasms. We present a case of a 30 year old male who presented with swelling in the right retroauricular region since 4 years. Magnetic resonance imaging and computed tomography showed lesion with its epicentre in the post styloid compartment of right parapharyngeal space with superior extent around the petrous...
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Interleukin-33 pretreatment promotes metastatic growth of murine melanoma by reducing the cytotoxic capacity of CD8 + T cells and enhancing regulatory T cells: AbstractInterleukin-33 (IL-33) regulates innate and acquired immune response to pathogens, self-antigens and tumors. IL-33 effects on tumors depend on the dose and mode of administration along with the type of malignancy. We studied the effects of IL-33 on the development of primary and metastatic melanoma induced by B16-F1 cell line in C57BL/6...
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TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent mannerby Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, Michael Emerman The HIV-1 capsid protein makes up the core of the virion and plays a critical role in early steps of HIV replication. Due to its exposure in the cytoplasm after entry, HIV capsid is a target for host cell factors that act directly to block infection such as TRIM5α and MxB. Several host proteins also play a role in facilitating...
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Transcytosis subversion by M cell-to-enterocyte spread promotes <i>Shigella flexneri</i> and <i>Listeria monocytogenes</i> intracellular bacterial dissemination: by Camille Rey, Yuen-Yan Chang, Patricia Latour-Lambert, Hugo Varet, Caroline Proux, Rachel Legendre, Jean-Yves Coppée, Jost EnningaMicrofold (M) cell host-pathogen interaction studies would benefit from the visual analysis of dynamic cellular and microbial interplays. We adapted a human in vitro M cell model to...
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Intestinal restriction of <i>Salmonella</i> Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes: by Shauna M. Crowley, Xiao Han, Joannie M. Allaire, Martin Stahl, Isabella Rauch, Leigh A. Knodler, Bruce A. VallanceWe investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase-1/11...
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Multiple <i>Wolbachia</i> strains provide comparative levels of protection against dengue virus infection in <i>Aedes aegypti</i>: by Heather A. Flores, Jyotika Taneja de Bruyne, Tanya B. O'Donnell, Vu Tuyet Nhu, Nguyen Thi Giang, Huynh Thi Xuan Trang, Huynh Thi Thuy Van, Vo Thi Long, Le Thi Dui, Huynh Le Anh Huy, Huynh Thi Le Duyen, Nguyen Thi Van Thuy, Nguyen Thanh Phong, Nguyen Van Vinh Chau, Duong Thi Hue Kien, Tran Thuy Vi, Bridget Wills, Scott L. O'Neill, Cameron P....
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TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner: by Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, Michael EmermanThe HIV-1 capsid protein makes up the core of the virion and plays a critical role in early steps of HIV replication. Due to its exposure in the cytoplasm after entry, HIV capsid is a target for host cell factors that act directly to block infection such as TRIM5α and MxB. Several host proteins also play a role in facilitating...
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Portable, automated foot progression angle gait modification via a proof-of-concept haptic feedback-sensorized shoePublication date: Available online 13 April 2020Source: Journal of BiomechanicsAuthor(s): Haisheng Xia, Jesse M. Charlton, Peter B. Shull, Michael A. HuntBiomechanics11hThe effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feedingPublication date: Available online 12 April 2020Source: Journal...
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Effects of CPAP therapy on subcutaneous adipose tissue in patients with obstructive sleep apnea: a meta-analysis: AbstractPurposeContinuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA). However, studies provide conflicting results on the effects of CPAP on subcutaneous adipose tissue (SAT) in patients with OSA. We therefore performed a meta-analysis to evaluate whether or not CPAP has an effect on SAT in patients with OSA.MethodsStudies were retrieved...
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SimPET: a Preclinical PET Insert for Simultaneous PET/MR Imaging: AbstractPurposeSimPET/M7 system is a small-animal dedicated simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) scanner. The SimPET insert has been upgraded from its prototype with a focus on count rate performance and sensitivity. The M7 scanner is a 1-T permanent magnet-based compact MRI system without any cryogens. Here, we present performance evaluation results of SimPET along with the results of...
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JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice: AbstractMultiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation. Pharmacological manipulation of monoacylglycerol lipase (MAGL), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (2-AG), reduced skeletal tumour burden and osteolysis associated with osteosarcoma...
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Determination of trace elements in Sergio mirim : an evaluation of sample preparation methods and detection techniques: AbstractIn this work, some trace elements (As, Cd, Cr, Cu, and Pb) were determined for the first time in the crustacean Sergio mirim (Decapoda: Thalassinidea: Callianassidae) from Southern Coast (Rio Grande, RS) of Brazil. The trace element determination was carried out by graphite furnace atomic absorption spectrometry (GF AAS) and inductively coupled plasma mass spectrometry (ICP-MS)....
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[ASAP] Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection: ACS NanoDOI: 10.1021/acsnano.0c02439
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Curcumin phytosome modulates aluminum-induced hepatotoxicity via regulation of antioxidant, Bcl-2, and caspase-3 in rats: AbstractIncreasing entrance of aluminum chloride (AlCl3) in many fields exposes human beings to its biotoxicity. Thereby, the present study assesses the potential ameliorative role of curcumin phytosome (CP) on AlCl3-induced hepatotoxicity. Rats were divided into four groups (n = 6): group 1 served as control; group 2 received CP (200 mg CP/kg b.wt) for 21 days; group 3 injected...
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APRIL-dependent life-long plasmacyte maintenance and immunoglobulin production in humansInteractions between TNF ligand superfamily and TNF receptor superfamily play critical roles in B cell development and maturation. A proliferation-inducing ligand (APRIL), a member of the TNF ligand superfamily, is secreted from myeloid cells and known to induce the differentiation of memory B cells to plasmacytes.Allergy and Clinical Immunology8hDistinct associations of sputum and oral microbiota with atopic,...
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1Kitesurf injury trauma evaluation study: A prospective cohort study evaluating kitesurf injuries Christiaan JA van Bergen, Rik IK Weber, Tim Kraal, Gino MMJ Kerkhoffs, Daniël Haverkamp World J Orthop 11(4):243-251. Published online Apr 18, 2020. doi: 10.5312/wjo.v11.i4.243Abstract (6) | Core Tip (5) | Full Article (56) | Figures (1-3) (4) | Tables (1-4) (3) | Full Article (PDF)-3738K (5) | Full Article (Word)-1234K (2) | Audio-851K (0) | Peer-Review Report-349K (2) | Answering Reviewers-26K (1) | Scientific...
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Combined blockade of TGf-β1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment: AbstractThe interactions between tumor immune microenvironment (TIME) and pancreatic cancer cells can affect chemotherapeutic efficacy; however, the mechanisms still remain largely unknown. Thirty items in TIME were comprehensively screened by using tissue microarray from pancreatic cancer patients. Their expressions, interconnections and predictive roles for survival...
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Direct Oral Anticoagulants in Patients with Liver Disease in the Era of Non-Alcoholic Fatty Liver Disease Global Epidemic: A Narrative Review: AbstractAtrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent and relevant healthcare issues. Direct oral anticoagulants (DOACs) are now the first-choice for anticoagulant treatment of these conditions displaying a better efficacy/safety profile than vitamin-K antagonists, mainly due to significantly reduced risk of major bleeding,...
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Hyoid-complex elevation and stimulation technique restores swallowing function in patients with lateral medullary syndrome: Two case reports.: Related ArticlesHyoid-complex elevation and stimulation technique restores swallowing function in patients with lateral medullary syndrome: Two case reports.World J Clin Cases. 2020 Mar 26;8(6):1142-1149Authors: Jiang YE, Lyu QQ, Lin F, You XT, Jiang ZLAbstract BACKGROUND: A swallowing disorder may occur following a brainstem stroke, especially one...
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Cerebral venous sinus thrombosis following transsphenoidal surgery for craniopharyngioma: A case report.: Related ArticlesCerebral venous sinus thrombosis following transsphenoidal surgery for craniopharyngioma: A case report.World J Clin Cases. 2020 Mar 26;8(6):1158-1163Authors: Chang T, Yang YL, Gao L, Li LHAbstract BACKGROUND: Cerebral venous sinus thrombosis (CVST) is a rare condition in patients with craniopharyngioma following transsphenoidal surgery. CASE SUMMARY: A 56-year-old...
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Articles In Press,1Chen LR, Chen ZX, Liu YC, Peng L, Zhang Y, Xu Q, Lin Q, Tao YM, Wu H, Yin S, Hu YJ. Pulmonary contusion mimicking COVID-19: A case report. World J Clin Cases 2020; In press2020-04-11 | Browse: 14 | Download: 112Hajifathalian K, Mahadev S, Schwartz R, Shah S, Sampath K, Schnoll-Sussman F, Brown Jr RS, Carr-Locke D, Cohen DE, Sharaiha RZ. SARS-CoV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant. World J Gastroenterol 2020; In press2020-04-11 | Browse: 14...
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Contents Volume 8 Issue 7 April 6, 2020ReviewSarcopenia in patients with colorectal cancer: A comprehensive review Omar Vergara-Fernandez, Mario Trejo-Avila, Noel Salgado-Nesme World J Clin Cases 8(7):1188-1202. Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1188Abstract (9) | Core Tip (7) | Full Article (HTML) (62) | Tables (1-1) (10) | Full Article (PDF)-776K (27) | Full Article (Word)-83K (8) | Audio-722K (5) | Peer-Review Report-207K (6) | Answering Reviewers-210K (8) | CrossRef | Google...
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Laparoscopic repair of complete intrathoracic stomach with iron deficiency anemia: A case report. Related ArticlesLaparoscopic repair of complete intrathoracic stomach with iron deficiency anemia: A case report.World J Clin Cases. 2020 Mar 26;8(6):1180-1187Authors: Yasheng D, Wulamu W, Li YL, Tuhongjiang A, Abudureyimu KAbstractBACKGROUND: Giant paraesophageal hiatal hernias (HH) are very infrequent, and their spectrum of clinical manifestations is large. Giant HH mainly occurs in elderly patients,...
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World J Clin Cases. 2019 Feb 26; 7(4): 405–418.Published online 2019 Feb 26. doi: 10.12998/wjcc.v7.i4.405PMCID: PMC6397821PMID: 30842952Immune checkpoint inhibitor-induced colitis: A comprehensive reviewAniruddh Som, Rohan Mandaliya, Dana Alsaadi, Maham Farshidpour, Aline Charabaty, Nidhi Malhotra, and Mark C MattarAuthor information Article notes Copyright and License information DisclaimerAniruddh Som, Department of Internal Medicine, Medstar Washington Hospital Center, Washington, DC 20010, United...
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Leucine-rich α2-glycoprotein as a potential biomarker for immune-related colitis after anti-PD-1 therapy: A report of case series: The use of immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis is one of the main therapies for advanced non-small-cell lung cancer (NSCLC). With the increasing use of ICIs, immune-related adverse events (irAEs) are also been increasing reported.1 Immune-related colitis is an important irAE.2 Grade 3 immune-related colitis develops in 1%–2% of the patients...
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Sonography of the penis/erectile dysfunction: AbstractErectile dysfunction (ED) is defined as the persistent inability to achieve and/or maintain an erection for a satisfactory sexual activity. It is secondary to several organic, psychogenic, and combined causes, and represents a serious health dilemma affecting both men and their partners. The diagnostic approach to erectile dysfunction has significantly changed in the last years with the advent of phosphodiesterase-5 (PDE5) inhibitors, and with...
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A "Catastrophic" Heparin-Induced Thrombocytopenia: Background. Heparin-induced thrombocytopenia (HIT) is a transient, antibody-mediated thrombocytopenia syndrome that usually follows exposure to unfractioned heparin (UFH) or low-molecular-weight heparin (LMWH). In contrast to other pathological conditions which lead to thrombocytopenia and bleeding complications, HIT results in a paradoxical prothrombotic state. It is caused by antibodies directed to complexes containing UFH or LMWH and a self-platelet...
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Pepsinogen Serology and Gastritis OLGA Staging in Mucosal Atrophy Assessment: A Cross-Sectional Study Involving East China Endoscopy Population: The histological gastric stage (OLGA) plays an important role in evaluating gastric atrophy, a symptom which suggests a risk of gastric cancer (GC). However, gastroscopy is an invasive examination, which has limited application in populations undergoing physical examination. Serum pepsinogen (PG) and gastin-17 (G-17) levels are noninvasive indexes which...
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Electricity, Neurology, and Noninvasive Brain Stimulation: Looking Back, Looking Ahead: Electricity and neurology evolved synchronously over the past few centuries. This article looks at their origins and their journey into noninvasive brain stimulation technique of transcranial direct current stimulation (tDCS), which is now popular in neuroscience research.
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The Mechanisms of the Herbal Components of CRSAS on HK-2 Cells in a Hypoxia/Reoxygenation Model Based on Network Pharmacology: Background. Acute kidney injury is a global problem, which brings a great burden to the society and family. The component of rhubarb, Salvia miltiorrhiza, Astragalus membranaceus, and safflower (CRSAS) has been proved as an useful agent to treat acute kidney injury (AKI) patients in China. Objective. To assess the effect of CRSAS on human renal tubular epithelial cells (HK-2)...
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Group versus Individual Acupuncture (AP) for Cancer Pain: A Randomized Noninferiority Trial: Background. A service delivery model using group acupuncture (AP) may be more cost-effective than individual AP in general, but there is little evidence to assess whether group AP is a comparable treatment in terms of efficacy to standard individual AP. The study aimed to compare the group to individual delivery of 6-week AP among cancer patients with pain. Methods. The study design was a randomized noninferiority...
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Role of Albumin as a Nutritional and Prognostic Marker in Elective Intestinal Surgery: Background. The aim of this study was to investigate albumin, nutritional status, and inflammation in the perioperative course of patients undergoing elective intestinal surgery. Methods. A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. Preoperatively, the correlation...
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Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM: Glycogen hepatopathy (GH) is a rare complication of type 1 diabetes mellitus that leads to an abnormal accumulation of glycogen in the hepatocytes. The exact mechanism of GH remains unknown, but fluctuations in blood glucose and insulin levels play important roles in promoting glycogen accumulation. We report a case of a 16-year-old female diagnosed with poorly controlled type 1 diabetes mellitus with hepatomegaly...
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CNTNAP1 Mutations and Their Clinical Presentations: New Case Report and Systematic Review: Lethal congenital contracture syndrome type 7 (LCCS7) and congenital hypomyelinating neuropathy type 3 (CHN3) are rare autosomal recessive diseases, characterized by severe neonatal hypotonia, polyhydramnios, arthrogryposis, facial diplegia, and severe motor paralysis, leading to death in early infancy. They are related to mutations in the CNTNAP1 (contactin associated protein 1) gene, playing an important...
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CNTNAP1 Mutations and Their Clinical Presentations: New Case Report and Systematic Review: Lethal congenital contracture syndrome type 7 (LCCS7) and congenital hypomyelinating neuropathy type 3 (CHN3) are rare autosomal recessive diseases, characterized by severe neonatal hypotonia, polyhydramnios, arthrogryposis, facial diplegia, and severe motor paralysis, leading to death in early infancy. They are related to mutations in the CNTNAP1 (contactin associated protein 1) gene, playing an important...
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Therapeutic Effect of Intense Pulsed Light (IPL) Combined with Meibomian Gland Expression (MGX) on Meibomian Gland Dysfunction (MGD): Purpose. Our study aimed to evaluate the efficiency of intense pulsed light (IPL) combined with meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD). Methods. This study was a prospective interventional study. A total of 53 patients were included in the study and received a series of three treatments at an interval of 3-4 weeks. Follow-up...
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Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-κB Signaling and Improving Gut Microbiota: Background. Picroside II exerts anti-inflammatory and antidiarrheal effects for treating the diseases associated with oxidative injury. However, its function on pancreatitis-induced intestinal barrier injury remains unclear. Hypothesis/Purpose. We hypothesized that picroside II will have protective effects...
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Role of the eNOS Uncoupling and the Nitric Oxide Metabolic Pathway in the Pathogenesis of Autoimmune Rheumatic Diseases: Atherosclerosis and its clinical complications constitute the major healthcare problems of the world population. Due to the central role of endothelium throughout the atherosclerotic disease process, endothelial dysfunction is regarded as a common mechanism for various cardiovascular (CV) disorders. It is well established that patients with rheumatic autoimmune diseases are characterized...
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Spectrophotometric Determination of Calcium with Dibromo-p-methylsulfonazo: Calcium is a necessary trace element in the human body, and its low or high content in the human body is not appropriate. It is very meaningful to study the level of calcium in the human body and to determine calcium content in blood. As people take calcium through food, the determination of calcium content in certain tea and calcium supplements is of great significance. In this study, a new method for the determination of...
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Evaluation of Cerebral Blood Flow Dynamics in Transient Ischemic Attacks Patients with Fast Cine Phase Contrast Magnetic Resonance Angiography: Fast cine phase contrast magnetic resonance angiography (PC-MRA) has the potential to provide a quantitative measurement method for the diagnosis and treatment of cerebrovascular disease. To evaluation the changes of cerebral blood flow and the characteristics of artery lesion distribution in the patients of transient ischemic attacks (TIA). In all, 98 normal...
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Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement: Purpose. Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis. There is convincing evidence from many studies that left atrium fibrosis is involved in the pathophysiology of AF. Therefore, we speculated that Neu5Ac may be associated with atrial...
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Angiosarcoma of an Arteriovenous Fistula for Hemodialysis in a Kidney Transplant Recipient Affected by Lowe's Syndrome: Objective/Background. To describe an uncommon, life-threatening condition such as angiosarcoma of a fistula for hemodialysis occurring in a transplant recipient affected by Lowe's syndrome. Summary. We present the case of a 56-year-old male kidney transplant recipient affected by Lowe's syndrome, also known as oculocerebrorenal syndrome, a rare X-linked disorder characterized by...
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Investigating Tunneling Nanotubes in Cancer Cells: Guidelines for Structural and Functional Studies through Cell Imaging: By allowing insured communication between cancer cells themselves and with the neighboring stromal cells, tunneling nanotubes (TNTs) are involved in the multistep process of cancer development from tumorigenesis to the treatment resistance. However, despite their critical role in the biology of cancer, the study of the TNTs has been announced challenging due to not only the absence...
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Effect of Deep Sedation on Mechanical Power in Moderate to Severe Acute Respiratory Distress Syndrome: A Prospective Self-Control Study: Mechanical power (MP) is a parameter for assessing ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Deep sedation inhibits the respiratory center and reduces the excessive spontaneous breathing in ARDS patients, thereby reducing transpulmonary pressure (Ptp) and lung injury. However, the effect of sedation on MP...
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The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining: To reconstruct the ceRNA biological network of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and to select an appropriate mRNA as a biomarker that could be used for CESC early diagnosis and prognosis evaluation. We downloaded CESC data from the TCGA public database, and statistical analysis was conducted with the R software to find out differential...
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The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway:
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Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones. [Molecular Bases of Disease]: Heat shock protein 70 (HSP70) chaperones play a central role in protein quality control and are crucial for many cellular processes, including protein folding, degradation, and disaggregation. Human HSP70s compose a family of thirteen members that carry out their functions with the aid of even larger families of co-chaperones. A delicate interplay between HSP70s and...
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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency [Enzymology]: Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of the investigational nucleotide analogue...
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Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis [Signal Transduction]: Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that critically supports the physicochemical and mechanical properties of the skin. Here, we demonstrate that mycosporine-like amino acids (MAAs), which typically function as UV-absorbing compounds, can stimulate HA secretion from normal human fibroblasts. MAA-stimulated...
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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency [Enzymology]3hby Calvin J Gordon, Egor P Tchesnokov, Emma Woolner, Jason K Perry, Joy Y. Feng, Danielle P Porter, Matthias Gotte via JBC Papers in PressEffective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,