Treating fungus‐induced allergic asthma: Do VDACs have the answer!The Journal of PhysiologyMon Mar 16, 2020 19:06Mark above section as read Journal of AnatomyA morphometric analysis of the lungs of high‐altitude ducks and geeseWe found that the mass‐specific lung volumes and the mass‐specific volume of exchange tissue were larger in the lungs of high‐altitude resident waterfowl than in those of low‐altitude resident and high‐altitude migratory waterfowl. We also found evidence of an inverse relationship...
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Critically ill benign EEG variants: is there such a thing?Publication date: Available online 16 March 2020Source: Clinical NeurophysiologyAuthor(s): Graham A. McLeod, Michelle-Lee Jones, Marcus C. NgClinical NeurophysiologyMon Mar 16, 2020 22:40Mark above section as read Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την ΕυεξίαΚορωνοϊός: Ομάδα Ισπανών ερευνητών πέτυχε να αναλύσει για πρώτη φορά ολόκληρο το γονιδίωμα του SARS-CoV2Η επιστημονική ομάδα από ερευνητικά...
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Otology & Neurotology Current Issue,Piezosurgery in Translabyrinthine-Approach Exposure of the Internal Auditory CanalObjective: To assess the applicability of the piezoelectric device in translabyrinthine-approach exposure of the internal auditory canal. Methods: In three cases with vestibular schwannoma, the bone around the internal auditory canal was completely removed by means of piezosurgery. Evaluation was performed by an experienced surgeon, and a second relatively inexperienced surgeon....
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Bi‐allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cellsAbstract Loss of heterozygosity or mutation of the family with sequence similarity 46, member C (FAM46C) gene on chromosome band 1p12 is associated with shorter overall survival of patients with multiple myeloma (MM). In this study, using human MM cell lines (KMS‐11, OCI‐My5, and ANBL‐6), we generated FAM46C‐/‐ cell clones and examined the effect of disruption of FAM46C on cell survival...
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The Clinical Implications of Spontaneous Hemorrhage in Vestibular SchwannomasJ Neurol Surg BDOI: 10.1055/s-0040-1701676 Background Spontaneous hemorrhage into vestibular schwannomas (VSs) is rare and can render more rapid symptom onset and a seemingly poorer prognosis for an otherwise benign pathology. We describe our series of hemorrhagic VS (HVSs) and systematically reviewed the literature to better understand relevant clinical factors and outcomes. Methods Retrospective case review series and...
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Latest Results for Current MicrobiologyValidation of Camel's Fetal Fluids as Antimicrobial AgentsAbstract The present work investigated the effect of camel's fetal fluids on a variety of bacterial and fungal pathogens. Ten samples of camel's amniotic and allantoic fluids were collected aseptically during parturition and their antimicrobial activities were evaluated by disc diffusion method and minimum inhibitory concentration (MIC) assay. The majority of tested pathogens were inhibited by both fluids...
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Biomedicines, Vol. 8, Pa Organo-Selenium-Containing Polyester Bandage Inhibits Bacterial Biofilm Growth on the Bandage and in the WoundBiomedicines, Vol. 8, Pages 62: Organo-Selenium-Containing Polyester Bandage Inhibits Bacterial Biofilm Growth on the Bandage and in the Wound Biomedicines doi: 10.3390/biomedicines8030062 Authors: Phat Tran Tyler Enos Keaton Luth Abdul Hamood Coby Ray Kelly Mitchell Ted W. Reid The dressing material of a wound plays a key role since bacteria can live in the bandage...
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Pharmacy, Vol. 8, Pages 41: Effects of a Remote Antimicrobial Stewardship Program on Antimicrobial Use in a Regional Hospital SystemPharmacy, Vol. 8, Pages 41: Effects of a Remote Antimicrobial Stewardship Program on Antimicrobial Use in a Regional Hospital System Pharmacy doi: 10.3390/pharmacy8010041 Authors: Joshua Knight Jessica Michal Stephanie Milliken Jenna Swindler While antimicrobial stewardship programs (ASPs) are well established at most large medical centers, small or rural facilities...
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Journal of Clinical MedicineJCM, Vol. 9, Pages 801: Radiographic Sagittal Tibio-Talar Offset in Ankle Arthrodesis—Accuracy and Reliability of MeasurementsJCM, Vol. 9, Pages 801: Radiographic Sagittal Tibio-Talar Offset in Ankle Arthrodesis—Accuracy and Reliability of Measurements Journal of Clinical Medicine doi: 10.3390/jcm9030801 Authors: Sophie Schieder Elena Nemecek Reinhard Schuh Alexander Kolb Reinhard Windhager Madeleine Willegger Radiographic outcome assessment of ankle arthrodesis (AA)...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 2038: Macrophage-secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial CellsIJMS, Vol. 21, Pages 2038: Macrophage-secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062038 Authors: Urbschat Thiemens Mertens Rehwald Meier Baer Jung Lipocalin-2 (Lcn-2) is rapidly upregulated in macrophages...
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Foods, Vol. 9, Pages 344: Mesopelagic Species and Their Potential Contribution to Food and Feed Security—A Case Study from NorwayFoods, Vol. 9, Pages 344: Mesopelagic Species and Their Potential Contribution to Food and Feed Security—A Case Study from Norway Foods doi: 10.3390/foods9030344 Authors: Anita R. Alvheim Marian Kjellevold Espen Strand Monica Sanden Martin Wiech The projected increase in global population will demand a major increase in global food production. There is a need for more biomass...
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Antibiotics, Vol. 9, Pages 124: Actinomycosis of the Tongue: A Case Report and Review of LiteratureAntibiotics, Vol. 9, Pages 124: Actinomycosis of the Tongue: A Case Report and Review of Literature Antibiotics doi: 10.3390/antibiotics9030124 Authors: Fiorella D'Amore Roberto Franchini Laura Moneghini Niccolò Lombardi Giovanni Lodi Andrea Sardella Elena M. Varoni Background: Actinomycosis of the tongue is an uncommon, suppurative infection of lingual mucosa, caused by actinomyces. The clinical diagnosis...
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Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western MedicineAbstract Objective To investigate the long-term therapeutic effects of the Chinese medicine Jiannao Yizhi Formula (健脑益智方, JYF) in the treatment of Alzheimer's disease (AD). Methods Sixty mild-to-moderate AD participants were recruited and randomly allocated to the treatment (30 with JYF) and the control groups (30 with donepezil) for 6 months...Latest Results23hEffects of Hirudin...
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A case of abdominal wall percutaneous endoscopic gastrostomy site metastatic disease from primary oropharyngeal squamous cell carcinoma:
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Cells, Vol. 9, Pages 735: Indirect Role of AQP4b and AQP4d Isoforms in Dynamics of Astrocyte Volume and Orthogonal Arrays of ParticlesCells, Vol. 9, Pages 735: Indirect Role of AQP4b and AQP4d Isoforms in Dynamics of Astrocyte Volume and Orthogonal Arrays of Particles Cells doi: 10.3390/cells9030735 Authors: Marjeta Lisjak Maja Potokar Robert Zorec Jernej Jorgačevski Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis in the central nervous system (CNS). It is...
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Antibiotics, Vol. 9, Pages 124: Actinomycosis of the Tongue: A Case Report and Review of Literature: Antibiotics, Vol. 9, Pages 124: Actinomycosis of the Tongue: A Case Report and Review of LiteratureAntibiotics doi: 10.3390/antibiotics9030124Authors: Fiorella D'Amore Roberto Franchini Laura Moneghini Niccolò Lombardi Giovanni Lodi Andrea Sardella Elena M. Varoni Background: Actinomycosis of the tongue is an uncommon, suppurative infection of lingual mucosa, caused by actinomyces....
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Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia modelPublication date: Available online 16 March 2020Source: Journal of Controlled ReleaseAuthor(s): Xing Pei, Heejung Kim, Minjoo Lee, Nana Wang, Jiyoung Shin, Seungjin Lee, Miyun Yoon, Victor C. Yang, Huining HeScienceDirect Publication: Journal of Controlled Release15hMark above section as read Latest ResultsVisionen für das metastasierte Mammakarzinom 2020Latest...
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Melatonin is useful alternative for sedation in children undergoing auditory brainstem responses testing: AbstractAuditory brainstem responses testing (ABRs) is frequently required to assess auditory function in children. It is done usually in outpatient fashion and requires deep sleep to avoid artefacts. Sedation method used for the test should allow a deep sleep while avoiding general anaesthesia that requires special monitoring, dedicated staff and operating room availability. For this purpose,...
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Galeone San José: Schatzjagd und Unterwasserkulturerbe - Art. 16 der UNESCO-Konvention von 2001 ermöglicht effektive Schutzmassenahmenedoc: No conditions. Results ordered -Date Deposited.16hTagungsbericht: Teaching History in the Digital Age - International Perspectives #dhiha8, 17.06.2019-18.06.2019 Parisedoc: No conditions. Results ordered -Date Deposited.16hSchweizerische Geschichtstage 2019: Digitalisierung und Digital Historyedoc: No conditions. Results ordered -Date Deposited.17hOdysseus as...
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Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis: AbstractPentoxifylline (PTX) is a candidate adjuvant medication for the treatment of sepsis and necrotizing enterocolitis in preterm infants. There is only limited data on safety and compatibility with other commonly used intravenous medications. This retrospective single-center study of 198 preterm infants (September 2012–September 2018) was performed at a level IV neonatal intensive...
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Protein–protein interactions of ER–resident selenoproteins with their physiological partnersPublication date: Available online 15 March 2020Source: BiochimieAuthor(s): Varlamova Elena GennadyevnaScienceDirect Publication: Biochimie12hMark above section as read Latest ResultsCorrection to: A Proposed Treatment Approach to Treat Lethal Mutating CancersOn the first page, third paragraph of the introduction, the second sentence should have a typographical correction to state -.Latest Results12hMark above...
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Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicityIron a tiny molecule with huge effects. Our findings showed that iron participates in drug resistance and iron‐overload can be considered as a risk factor for relapse. In an attempt to minimize the probability of drug resistance and improve the treatment outcomes in children with ALL, it is suggested that patients' bone marrow iron stores must be assessed during chemotherapy, and the number of blood transfusions...
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Characterization of proliferation, differentiation potential, and gene expression among clonal cultures of human dental pulp cellsAbstract Mesenchymal stem cells are a highly promising source of cells for regeneration therapy because of their multilineage differentiation potential. However, distinct markers for mesenchymal stem cells are not well-established. To identify new candidate marker genes for multipotent human dental pulp stem cells, we analyzed the characteristics and gene expression profiles...
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Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axisCurrently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of gastric cancer (GC). We aimed to investigate the role of circ_0008035 in GC progression.Cancer Cell International - Latest Articles7hMark above section as read British Journal of Cancer - Issue - nature.com science feedsDifferential prognostic impact of CD8<sup>+</sup>...
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Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients: AbstractBackgroundAsbestos is the primary known cause of malignant mesothelioma. Some cosmetic talc products have been shown to contain asbestos. Recently, repeated exposures to cosmetic talc have been implicated as a cause of mesothelioma.MethodsSeventy‐five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum...
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Immune-related prognosis biomarkers associated with osteosarcoma microenvironmentOsteosarcoma is a highly aggressive bone tumor that most commonly affects children and adolescents. Treatment and outcomes for osteosarcoma have remained unchanged over the past 30 years. The relationship betw...Cancer Cell International - Latest Articles7hCirc_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axisCurrently, multiple circular RNAs (circRNAs)...
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Bi‐allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells: AbstractLoss of heterozygosity or mutation of the family with sequence similarity 46, member C (FAM46C) gene on chromosome band 1p12 is associated with shorter overall survival of patients with multiple myeloma (MM). In this study, using human MM cell lines (KMS‐11, OCI‐My5, and ANBL‐6), we generated FAM46C‐/‐ cell clones and examined the effect of disruption of FAM46C on cell survival...
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Experimental Study of Tumor Therapy Mediated by Multimodal Imaging Based on a Biological Targeting Synergistic AgentInternational Journal of Nanomedicine7hImproving Cell Penetration of Gold Nanorods by Using an Amphipathic Arginine Rich PeptideInternational Journal of Nanomedicine8hAcute Damage to the Sperm Quality and Spermatogenesis in Male Mice Exposed to Curcumin-Loaded NanoparticlesInternational Journal of Nanomedicine8hImplementation of PPI with Nano Amorphous Oxide Semiconductor Devices for...
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Viruses, Vol. 12, Pages 314: Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of InfectionViruses, Vol. 12, Pages 314: Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection Viruses doi: 10.3390/v12030314 Authors: Albulescu White-Scholten Tas Hoornweg Ferla Kovacikova Smit Brancale Snijder van Hemert Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause a debilitating...
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Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3K/AKT Signaling PathwayObjectives. Flufenamic acid (FFA) is a representative of the fenamic acids, an important group of NSAIDs. In the present study, we study the effects of FFA on adipogenesis of human mesenchymal stem cells (MSCs) and we explore the potential mechanism. Methods. To investigate the effects of FFA on adipogenic differentiation of hMSCs, human adipose-derived stem cells (hASCs) and...
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Cavitary Pneumonia: A Complication of Antibiotic Noncompliance: In this report, we present a complicated case of community-acquired pneumonia in a 5-year-old boy. The patient first presented to the pulmonology clinic with the diagnosis of asthma and a recent history of recurrent pneumonia. Poor compliance to two courses of outpatient oral antibiotics resulted in persistent pneumonia symptoms with unresolved radiographic findings warranting parenteral antibiotics. Despite 2 symptom-free weeks, the...
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JCM, Vol. 9, Pages 812: Research Insights on Neural Effects of Auditory Deprivation and Restoration in Unilateral Hearing Loss: A Systematic Review: JCM, Vol. 9, Pages 812: Research Insights on Neural Effects of Auditory Deprivation and Restoration in Unilateral Hearing Loss: A Systematic ReviewJournal of Clinical Medicine doi: 10.3390/jcm9030812Authors: Jolijn Vanderauwera Elisabeth Hellemans Nicolas Verhaert Neuroplasticity following bilateral deafness and auditory restoration has been repeatedly...
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Prevalence of Diabetic Foot Ulcer and Associated Factors among Adult Diabetic Patients on Follow-Up Clinic at Jimma Medical Center, Southwest Ethiopia, 2019: An Institutional-Based Cross-Sectional Study: Background. Diabetic foot ulceration is a devastating complication of diabetes mellitus and is a major source of morbidity and mortality. So far, there are few published data on diabetic foot ulcers and its determinants among diabetic patients on follow-up at Jimma Medical Center. Hence, the aim...
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Alleviating the Hydrolysis of Carbohydrates, Tangzhiqing (TZQ) Decreased the Postprandial Glycemia in Healthy Volunteers: An Eight-Period Crossover Study: Tangzhiqing (TZQ), a Chinese herbal medicine, has been widely used to treat diabetes mellitus in China. TZQ works as a potential α-glucosidase inhibitor to reduce the absorption of glucose from dietary carbohydrates. The main aim of this study was to investigate the postprandial glucose-lowering effect of TZQ on the common carbohydrates in healthy...
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Homology Modeling and Virtual Screening Studies of Antigen MLAA-42 Protein: Identification of Novel Drug Candidates against Leukemia—An In Silico Approach: Monocytic leukemia-associated antigen-42 (MLAA-42) is associated with excessive cell division and progression of leukemia. Thus, human MLAA-42 is considered as a promising target for designing of new lead molecules for leukemia treatment. Herein, the 3D model of the target was generated by homology modeling technique. The model was then evaluated...
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Natural Chalcones in Chinese Materia Medica: Licorice: Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According...
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Antistaphylococcal Activity of Extracts, Fractions, and Compounds of Acacia polyacantha Wild (Fabaceae): Acacia polyacantha is a medicinal plant traditionally used to treat livestock diseases and gastrointestinal infections; our study was undertaken to evaluate the antistaphylococcal activities of the methanolic leaf, bark, and root extracts, fractions, and compounds from Acacia polyacantha against a panel of 14 multidrug-resistant Staphylococcus bacterial strains overexpressing efflux pumps. The...
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Electroacupuncture Ameliorates Cerebral I/R-Induced Inflammation through DOR-BDNF/TrkB Pathway: The beneficial effects of electroacupuncture (EA) at Shuigou (GV26) and Neiguan (PC6) on poststroke rehabilitation are critically related to the activation of the delta-opioid receptor (DOR). The underlying anti-inflammatory mechanisms in DOR activation and EA-mediated neuroprotection in cerebral ischemia/reperfusion (I/R) injury were investigated in the current study. Cell proliferation and apoptosis...
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Topical Treatment of Truncal Acne with Tretinoin Lotion 0.05% and Azelaic Acid Foam: Truncal acne is present in approximately half of all patients with facial acne but is also occasionally seen in isolation. Important considerations when selecting treatment options for adult female acne, whether on the face, back, chest, or shoulders, include patient compliance, treatment response time, tolerability of the treatment, and psychosocial impact of the disease. Oral antibiotics are widely prescribed for...
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Anterior Ischemic Optic Neuropathy in a Child Receiving Chronic Hemodialysis: Anterior ischemic optic neuropathy (AION) occurs due to hypoperfusion of the optic nerve and is a rare complication in patients receiving maintenance dialysis. To date, AION has only been reported in 22 children, all of whom were receiving peritoneal dialysis. We report the first case of AION in a 2-year 11-month-old child receiving chronic hemodialysis secondary to polycystic kidney disease from a phosphomannomutase 2...
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Hyperparathyroidism Jaw Tumor Syndrome Presenting as Recurrent Femur Fractures in a Young Woman; a Rare Presentation of a Rare Disease: Background. Primary hyperparathyroidism usually occurs secondary to parathyroid adenoma, multiglandular hyperplasia, or parathyroid carcinoma. The patients usually present with incidentally discovered high calcium level and systemic or skeletal manifestations. In young patients with primary hyperparathyroidism, familial syndromes including multiple endocrine neoplasia...
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Waist-to-Height Ratio (WHtR) in Predicting Coronary Artery Disease Compared to Body Mass Index and Waist Circumference in a Single Center from Saudi Arabia: This study aims to study the efficiency of the Waist-to-Height Ratio (WHtR) for determining coronary artery disease. It compares the frequency of abnormal WHtR, as a proxy for abdominal obesity, to that of body mass index (BMI) and waist circumference (WC). It also relates the findings to other cardiometabolic risk factors in University Hospital...
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Are Basal-Like and Non-Basal-Like Triple-Negative Breast Cancers Really Different?: Objective. Triple-negative breast cancer (TNBC) accounts for 15–25% of breast cancers. It is increasingly recognized that TNBC is a motley disease. TNBC and basal-like (BL) subtype are different molecular classes of breast cancer with a high degree of overlap. However, a smaller fraction lacks the expression of basal markers in spite of being TNBC and is called non-basal-like (NBL). The aim of this study is to assess...
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Liberation from Dialysis Dependence in a Patient with HIV-Associated Nephropathy (HIVAN) after Combined Antiretroviral Therapy (cART): Prior to the advent of combined antiretroviral therapy (cART), human immunodeficiency virus-associated nephropathy (HIVAN) was inevitably associated with rapidly progressive renal failure and dialysis dependence. HIV-1 seropositive patients often met with untimely deaths due to complications of end-stage renal disease (ESRD), opportunistic infections, or other HIV-related...
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Sikyungbanha-Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3: Sikyungbanha-Tang (SKBHT) is a Chinese traditional medicine popularly prescribed to patients with respiratory inflammatory symptoms in Korea. Although the Korea Food and Drug Administration approved SKBHT as a therapeutics for relieving the symptoms, experimental evidence for SKBHT suppressing inflammation is scarce. Here, we presented evidence that SKBHT can suppress inflammation in an acute...
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Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies: The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of...
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Bouveret Syndrome: A Rare Case of Instance and Treatment in a Younger Patient: Bouveret syndrome, a specific form of gallstone ileus, is the obstruction of the gastric outlet by a gallstone, which can enter the duodenum through a fistula. While the average age of individuals with Bouveret syndrome is 74 years, our patient was 42 years of age at the time of operation, significantly younger than the average patient afflicted with this condition. In the treatment of our patient's condition, the operation...
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Isoliquiritigenin Attenuates Anxiety-Like Behavior and Locomotor Sensitization in Rats after Repeated Exposure to Nicotine: As important components of positive and negative reinforcement, locomotor sensitization and withdrawal anxiety following repeated exposure to nicotine (NIC) constitute crucial risk factors for relapse to NIC use after abstinence. Glycyrrhiza radix (G. radix), an important tonic used in traditional Oriental medicine, has not only anxiolytic effects but also reduces NIC-induced...
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Antiangiogenesis Roles of Exosomes with Fei-Liu-Ping Ointment Treatment are Involved in the Lung Carcinoma with the Lewis Xenograft Mouse Model: Exosomes display efficient biocompatibility and represent valuable vehicles for drug or effective material delivery in a tumour-therapeutic approach. Following treatment with Fei-Liu-Ping (FLP) ointment, a traditional Chinese herbal formula, which is used for treating lung cancer patients, could inhibit lung carcinoma growth in clinical and animal studies....
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Precision Augmentation of Medical Surge Capacity for Disaster Response: Background. In recent years, serious injuries associated with extreme climate, earthquakes, terrorism, and other natural and man-made disasters have occurred frequently throughout the world. A surge in medical demand that extends beyond local medical surge capacity in mass casualty incidents following major disasters is common. Materials and Methods. We reviewed and analyzed emergency medical rescue efforts after major disasters...
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Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition: The development of colorectal cancer (CRC) is a multistep process initiated by a benign polyp that has the potential to evolve into in situ carcinoma through the interactions between environmental and genetic factors. CRC incidence rates are constantly increased for young adult patients presenting an advanced tumor stage. The majority of CRCs arise from colonic adenomas originating...
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IJERPH, Vol. 17, Pages 1955: Impact of 12-Month Smartphone Breathing Meditation Program upon Systolic Blood Pressure among Non-Medicated Stage 1 Hypertensive Adults: IJERPH, Vol. 17, Pages 1955: Impact of 12-Month Smartphone Breathing Meditation Program upon Systolic Blood Pressure among Non-Medicated Stage 1 Hypertensive AdultsInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061955Authors: Jessica Chandler Luke Sox Vanessa Diaz Kinsey Kellam Allison...
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Comparison between Second- and Third-Generation PTH Assays during Minimally Invasive Parathyroidectomy (MIP): Context. Intraoperative PTH (IOPTH) drop of more than 50% during minimally invasive parathyroidectomy (MIP) predicts the surgery success. Comparison between second- and third-generation PTH assays (PTH 2G and PTH 3G) on IOPTH decline is scarce. The aim of this study is to compare both assays and to determine the predictors of IOPTH decline. Methods. 112 patients (of which 72.3% females) underwent...
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Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells: Background. Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formation of age-related cataract. Material and Methods. Real-time PCR and western blot were...
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Microscopic Polyangiitis Initially Presumed to Be Endocarditis: The antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAVs), which include fever of unknown origin (FUO), are rare diseases characterized by necrotizing inflammation of small blood vessels and the presence of ANCAs. Microscopic polyangiitis (MPA) is a subtype of the AAVs. Although the prevalence of AAVs has generally increased over the last 20 years, there have been rare reports from the dental and oral surgery field....
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A Rare Case of Chronic Uterine Inversion Secondary to Submucosal Fibroid Managed in the Province Hospital of Nepal: Uterine inversion secondary to uterine pathology is a rare scenario that a gynecologist encounters. Unlike puerperal uterine inversion, it is misleading and may not always be possible to reduce to normal position without surgery. We report a case of a 35-year female with per vaginal bleeding for fifteen months with a mass-like sensation in the vaginal canal. She presented in shock and...
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Ischemic Postconditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3β/Nrf2 Pathway in Mice: Aims. Ischemic postconditioning (IPO) has a strong protective effect against intestinal ischemia-reperfusion (IIR) injury that is partly related to autophagy. However, the precise mechanisms involved are unknown. Methods. C57BL/6J mice were subjected to unilateral IIR with or without IPO. After 45 min ischemia and 120 min...
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Berberine Inhibits MDA-MB-231 Cells by Attenuating Their Inflammatory Responses: Breast cancer initiation is closely associated with cytokines that can change the inflammatory tumor microenvironment. Compounds extracted from plants have been explored for the possibility of cancer treatment in the recent decades. Berberine is an isoquinoline plant alkaloid with remarkable antioxidant and anti-inflammation roles, which is used in ethnic medicines, including traditional Chinese and North American medicine....
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Early Exposure to Gut Microbiome Reduces Hepatocellular Carcinoma Risks in Mice: Aims. Liver cancer is a multietiological disease that has multiple factors contributing to the hepatocarcinogenic process, e.g., hepatitis viruses, carcinogens, male sex, or metabolic factors. Notably, emerging evidence reported that gut microbiota is crucial to the pathogenesis of hepatocellular carcinoma (HCC) via activation of innate immunity. However, the effect of time to gut microbiota exposure after birth is unknown....
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The Forgotten Disease: A Case of Lemierre's Syndrome with Distal Extremity Involvement: Once coined the "Forgotten Disease," Lemierre's syndrome is a rare condition that results from oropharyngeal infection with the gram-negative, anaerobic Fusobacterium necrophorum. The typical progression of illness involves spread to adjacent structures such as the internal jugular vein with resulting thrombophlebitis. Septic emboli to distant sites are also a common sequela. Here, we present a case of Lemierre's...
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Kidney Salvage with Renal Artery Reconstruction after Blunt Traumatic Injury: Renal artery injury from blunt abdominal trauma is a rare condition that is typically managed nonoperatively in hemodynamically stable patients. Revascularization can be achieved by stenting or surgical reconstruction of the renal artery. All attempts at revascularization should minimize warm ischemic time. Here, we discuss a patient postmotor vehicle accident who presented to Ryder Trauma Center with intra-abdominal bleeding....
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Successful Endovascular Repair of a Ruptured Popliteal Artery Aneurysm: A Case Report and Literature Review: Introduction. It is rare for a popliteal artery aneurysm (PAA) to present with rupture. This case reports a longer-term success in the management of a large ruptured popliteal artery aneurysm with an endovascular approach, with a literature review of management of such cases. Case Report. An 80-year-old man presented to the accident and emergency department with pain and swelling behind the...
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Infection-Associated Cancers: After the finding by Peyton Rous that filtered extracts from chicken sarcoma generated new sarcoma, numbers of pathogens have been found to be oncogenic. Microorganisms and their metabolites, as well as chronic inflammation, have also been considered to cause cancers. Almost 20% of all cancers worldwide are estimated to be associated with infections. However, we believe cancers caused by infection include many effective preventive measures, which include a potential...
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Carbamazepine Toxicity Masquerading as Complex Febrile Seizures in a Pediatric Patient: Carbamazepine is an antiepileptic drug that can cause seizures in overdose. In certain patient populations, this may be misdiagnosed as a seizure disorder. We describe a case of a 20-month-old female who presented with fever and seizure-like activity who was initially thought to have complex febrile seizures. Further historical information prompted carbamazepine level to be checked, which was found to be 29 mcg/ml...
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Dual HER2 Blockade versus a Single Agent in Trastuzumab-Containing Regimens for HER2-Positive Early Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials: Purpose. Although trastuzumab is the standard of care for patients with human epidermal growth factor receptor 2 (HER2)- positive early breast cancer (EBC), drug resistance and disease relapse occur. Therefore, we performed a meta-analysis to assess the efficacy and safety of trastuzumab-containing dual anti-HER2...
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A Comprehensive Review on Schisandrin B and Its Biological Properties: Nature is a vast source of bioactive molecules and has provided an active and efficient reservoir for drug discovery. Among natural compounds, one of the most promising is Schisandrin B (Sch B), isolated from Schisandra chinensis, which was documented to possess diversified pharmacokinetic propriety, among them antioxidant, anti-inflammation, cardioprotection, and neuroprotection. Due to its large biological properties, Sch B...
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Development of an Enzyme-Linked Immunosorbent Assay Method for the Detection of Rhein in Rheum officinale: Rhein is an important quality-control marker of Rheum officinale. The aim of this study was to develop an indirect competitive enzyme-linked immunosorbent assay (icELISA) for rhein detection, which acts as a powerful tool for quality control and proper usage of Rheum officinale. First, a specific and sensitive monoclonal antibody (mAb) against rhein was produced from a stable hybridoma cell...
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Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells: Recent comparisons between plant and animal viruses reveal many common principles that underlie how all viruses express their genetic material, amplify their genomes, and link virion assembly with replication. Cauliflower mosaic virus (CaMV) is not infectious for human beings. Here, we show that CaMV transactivator/viroplasmin protein (TAV) shares sequence similarity with and...
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Severe Malaria: A Case of a Significant Rapid Rise in the Parasite Level: Malaria is transmitted by the Plasmodium parasite, and most of the cases reported in the United States are often as a result of patients with recent return from endemic areas. Prompt diagnosis and treatment, particularly if there is severe parasitemia and drug failure, is essential in preventing mortality. Our patient had an unusual rapid rise in parasite but susceptible to intravenous artesunate.
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Bell's Palsy: A Prospective Study: Background. Bell's palsy is an acute idiopathic facial nerve paralysis of sudden onset. It is the most common cause of lower motor neuron facial nerve paralysis with an annual incidence of 15–30 per 100,000 population. The objective of this work is to study the grade of the attack and the associated symptoms of Bell's palsy in a group of Sudanese patients. The study type is an analytical prospective-based study. The study was carried out at Khartoum Teaching Dental...
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Ultrasound-Guided Percutaneous Balloon Aortic Valvuloplasty for Aortic Stenosis: Percutaneous balloon aortic valvuloplasty (PBAV), which is used to treat symptomatic aortic stenosis, requires ionizing radiation and contrast agent for imaging guidance. The aim of the study is to evaluate the feasibility and effectiveness of ultrasound-guided PBAV in patients with aortic stenosis. This case series included 30 patients (14 males; mean age, 61.5 ± 4.5 years) with moderate/severe aortic stenosis treated...
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Hypercalcemia-Induced ST-Segment Elevation Mimicking Acute Myocardial Injury: A Case Report and Review of the Literature: ST-segment elevation in absence of acute coronary syndrome can be seen in multiple conditions, including acute pericarditis and coronary vasospasm, but it is rarely seen with severe hypercalcemia. The authors present a case of an 81-year-old female with a history of stage 4 squamous cell cancer of the lung, who presented to the emergency room with profound fatigue, weakness, anorexia,...
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GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphateMetformin is an oral drug widely used for the treatment of type 2 diabetes mellitus. Numerous studies have demonstrated the value of metformin in cancer treatment. However, for metformin to elicit effects on cancer this often requires a high dosage, and any underlying mechanism for how to improve its inhibitory effects remains unknown. Here we found that low mRNA expression of glycerol-3-phosphate...
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Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin‐based emollient:
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A short-term inhalation study to assess the reversibility of sensory irritation in human volunteersAbstract Sensory irritation is an acute adverse effect caused by chemicals that stimulate chemoreceptors of the upper respiratory tract or the mucous membranes of the outer eye. The avoidance of this end point is of uttermost importance in regulatory toxicology. In this study, repeated exposures to ethyl acrylate were analyzed to investigate possible carryover effects from day to day for different markers...
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Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease [Lipids]Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids, and Gb3 analogs with modifications on the sphingosine moiety. However, Gb3 assays are often performed...
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JCM, Vol. 9, Pages 803: Ultrasonographic Changes of Major Salivary Glands in Primary Sjögren's Syndrome: JCM, Vol. 9, Pages 803: Ultrasonographic Changes of Major Salivary Glands in Primary Sjögren's SyndromeJournal of Clinical Medicine doi: 10.3390/jcm9030803Authors: Kyung-Ann Lee Sang-Heon Lee Hae-Rim Kim We aimed to evaluate the changes over time in salivary gland (SG) abnormalities by ultrasound (US) in patients with primary Sjögren's syndrome (pSS). Patients with pSS (n = 70) and idiopathic...
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JCM, Vol. 9, Pages 805: Does Treating Hearing Loss in Older Adults Improve Cognitive Outcomes? A Review: JCM, Vol. 9, Pages 805: Does Treating Hearing Loss in Older Adults Improve Cognitive Outcomes? A ReviewJournal of Clinical Medicine doi: 10.3390/jcm9030805Authors: Hélène Amieva Camille Ouvrard Hearing loss is the third most prevalent health condition in older age. In recent years, research has consistently reported an association between hearing loss and mental health outcomes, including...
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JCM, Vol. 9, Pages 804: Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled Trial: JCM, Vol. 9, Pages 804: Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled TrialJournal of Clinical Medicine doi: 10.3390/jcm9030804Authors: Tarek El-Bialy Khaled Farouk Terry D. Carlyle William Wiltshire Robert Drummond Tim Dumore ...
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JCM, Vol. 9, Pages 810: Understanding Primary Ciliary Dyskinesia: Experience From a Mediterranean Diagnostic Reference Centre: JCM, Vol. 9, Pages 810: Understanding Primary Ciliary Dyskinesia: Experience From a Mediterranean Diagnostic Reference CentreJournal of Clinical Medicine doi: 10.3390/jcm9030810Authors: Miguel Armengot-Carceller Ana Reula Manuel Mata-Roig Jordi Pérez-Panadés Lara Milian-Medina Carmen Carda-Batalla Background: Due to the lack of a gold standard diagnostic test,...
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Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cyclesObjectiveTo compare success rates, associated risks and cost-effectiveness between intrauterine insemination (IUI) and in vitro fertilisation (IVF). DesignRetrospective observational study. SettingThe UK from 2012 to 2016. ParticipantsData from Human Fertilisation and Embryology Authority's freedom of information request for 2012–2016 for IVF/ICSI (intracytoplasmic sperm injection)and...
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Phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: the WISTERIA trial protocol: IntroductionPatients with head and neck squamous cell carcinoma with locally advanced disease often require multimodality treatment with surgery, radiotherapy and/or chemotherapy. Adjuvant radiotherapy with concurrent chemotherapy is offered to patients with high-risk pathological features postsurgery....
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Indoor environmental quality and learning outcomes: protocol on large-scale sensor deployment in schoolsIntroductionExposure to poor environmental conditions has been associated with deterioration of physical and mental health, and with reduction of cognitive performance. Environmental conditions may also influence cognitive development of children, but epidemiological evidence is scant. In developed countries, children spend 930 hours per year in a classroom, second only to time spent in their bedroom....
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Changes to cardiovascular risk factors over 7 years: a prospective cohort study of in situ urbanised residents in the Chaoyang District of Beijing: ObjectivesTo examine changes in cardiovascular risk factors of in situ urbanised residents between 2010 and 2017.DesignPopulation-based cohort study.SettingThe Chaoyang District of Beijing, China.ParticipantsA total of 942 in situ urbanised rural residents aged 35–64 who participated in the cardiovascular disease (CVD) risk factors study in China between...
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Clinical and imaging features of IgG4-related kidney disease: AbstractPurposeTo assess the clinical and imaging features of IgG4-RKD for understanding and diagnosis of this disease.MethodsCT and MR images of 34 patients with IgG4-RKD were retrospectively analyzed by two radiologists in consensus.ResultsThe serum IgG4 level was found being increased in all patients. Renal involvement was bilateral (24/34, 70.6%) or unilateral (10/34,29.4%), multiple (29/34, 85.3%) or solitary (5/34, 14.7%). The lesions...
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Müllerian duct anomalies coincident with endometriosis: a review: AbstractThe association between obstructed müllerian duct anomalies and endometriosis has been well established and the pathogenesis is attributed to the theory of retrograde menstruation. However, this relationship with endometriosis is less clear in women with unobstructed müllerian duct anomalies and in those with rudimentary uterine structures that lack functioning endometrial tissue. This article reviews the embryology, genetics,...
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Genetic Pathway in the Pathogenesis of Therapy-Related Myeloid Neoplasms: A Literature Review: AbstractTherapy-related myeloid neoplasms are a life-threatening and often fatal complication, associated with poor prognosis outcomes and with high-risk unfavorable cytogenetic abnormalities including complex karyotype. They occur after the treatment of primary malignancies using chemotherapy and/or radiation therapy. Such therapy is not specific to cancer cells, and also damages the deoxyribonucleic acid...
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Dupuytren contracture: Dupuytren contracture: A localized formation of scar tissue in the palm of the hand within a tissue (fascia) beneath the skin of the palm that normally covers the tendons that pull the fingers into a grip. As Dupuytren's contracture progresses, more of the fascia becomes thickened and shortened. Dimpling and puckering of the skin over the area eventually occurs. The precise cause of of Dupuytren's contracture is not known. Causes include diabetes mellitus, seizure...
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IJERPH, Vol. 17, Pages 1929: An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program: IJERPH, Vol. 17, Pages 1929: An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity ProgramInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061929Authors: Sica Sagnelli Papa Ciccozzi Sagnelli...
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IJERPH, Vol. 17, Pages 1940: Concentrations of Formic Acid, Acetic Acid, and Ammonia in Newly Constructed Houses: IJERPH, Vol. 17, Pages 1940: Concentrations of Formic Acid, Acetic Acid, and Ammonia in Newly Constructed HousesInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061940Authors: Norimichi Suzuki Hiroko Nakaoka Akifumi Eguchi Masamichi Hanazato Yoshitake Nakayama Kayo Tsumura Kohki Takaguchi Kazunari Takaya Emiko Todaka ...
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IJERPH, Vol. 17, Pages 1945: Association between Food Label Unawareness and Loss of Renal Function in Diabetes: A Cross-Sectional Study in South Korea: IJERPH, Vol. 17, Pages 1945: Association between Food Label Unawareness and Loss of Renal Function in Diabetes: A Cross-Sectional Study in South KoreaInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061945Authors: Jae Hong Joo Doo Woong Lee Dong-Woo Choi Eun-Cheol Park Objectives: To examine sex differences...
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IJERPH, Vol. 17, Pages 1944: Stroke to Dementia Associated with Environmental Risks—A Semi-Markov Model: IJERPH, Vol. 17, Pages 1944: Stroke to Dementia Associated with Environmental Risks—A Semi-Markov ModelInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061944Authors: Kung-Jeng Wang Chia-Min Lee Gwo-Chi Hu Kung-Min Wang Background: Most stroke cases lead to serious mental and physical disabilities, such as dementia and sensory impairment. Chronic...
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IJERPH, Vol. 17, Pages 1947: New Application of Osteogenic Differentiation from HiPS Stem Cells for Evaluating the Osteogenic Potential of Nanomaterials in Dentistry: IJERPH, Vol. 17, Pages 1947: New Application of Osteogenic Differentiation from HiPS Stem Cells for Evaluating the Osteogenic Potential of Nanomaterials in DentistryInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061947Authors: Tetè Capparè Gherlone Objective: HiPS stem cells are commonly...
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IJERPH, Vol. 17, Pages 1949: Behavioral, Emotional and School Adjustment in Adolescents with and without Developmental Language Disorder (DLD) Is Related to Family Involvement: IJERPH, Vol. 17, Pages 1949: Behavioral, Emotional and School Adjustment in Adolescents with and without Developmental Language Disorder (DLD) Is Related to Family InvolvementInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061949Authors: Valera-Pozo Adrover-Roig Pérez-Castelló...
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IJERPH, Vol. 17, Pages 1954: The Relationship between Frailty Syndrome and Concerns about an Implantable Cardioverter Defibrillator: IJERPH, Vol. 17, Pages 1954: The Relationship between Frailty Syndrome and Concerns about an Implantable Cardioverter DefibrillatorInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061954Authors: Agnieszka Mlynarska Rafal Mlynarski Izabella Uchmanowicz Czeslaw Marcisz Krzysztof S. Golba Frailty syndrome may cause...
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Brain Sciences, Vol. 10, Pages 171: Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure: Brain Sciences, Vol. 10, Pages 171: Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ FailureBrain Sciences doi: 10.3390/brainsci10030171Authors: Meng-Yu Wu Chien-Sheng Chen Chih-Yi Tsay...
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Prospects of NSAIDs administration as double-edged agents against endometrial cancer and pathological species of the uterine microbiome.Cancer Biology & Therapy: Table of Contents: Taylor and FrancisSun Mar 15, 2020 07:29Mark above section as read Gene Expression PatternsEditorial BoardPublication date: January 2020Source: Gene Expression Patterns, Volume 35Author(s):Gene Expression PatternsMon Mar 16, 2020 14:34Outside Front Cover - Journal name, Cover image, Volume issue details, ISSN, Cover...
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Benign Alveolar Ridge Keratosis: Clinical and Histopathologic Analysis of 167 CasesAbstract Benign alveolar ridge keratosis (BARK), the intraoral counterpart of cutaneous lichen simplex chronicus, is a reactive hyperkeratosis caused by trauma or friction that presents as a poorly demarcated white papule or plaque on the keratinized mucosa of the retromolar pad or alveolar ridge mucosa (often edentulous). This is a clinical and histopathologic analysis of BARK including evaluation of p53 expression...
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Genomic and Transcriptomic Characterization of Sporadic Medullary Thyroid Carcinoma: Thyroid, Ahead of Print. AbstractBackground: Sporadic medullary thyroid carcinoma (MTC) is a relatively uncommon neuroendocrine malignancy and the molecular tumorigenesis of its sporadic type (sMTC) is only partially understood. In this study, we performed a study focusing on the genomic and transcriptomic characterization of sMTC.Methods: Twenty-nine sMTC patients were included. Whole-exome sequencing (WES) was...
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Clinical Experience in Treatment of Alzheimer's D...A case of abdominal wall percutaneous endoscopic g...Cells, Vol. 9, Pages 735: Indirect Role of AQP4b ...Antibiotics, Vol. 9, Pages 124: Actinomycosis of t...Local delivery of cardiac stem cells overexpressi...Melatonin is useful alternative for sedation in ch...Galeone San José: Schatzjagd und Unterwasserkultu...Intravenous pentoxifylline is well tolerated in cr...Protein–protein interactions of ER–resident selen...Iron protects childhood acute...
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OncologyComprehensive tumor profiling reveals un... pubmed: future oncologyDiffuse optical spectrosc... International Journal of SurgeryBeta-blocker exp... Skull BaseTreatment Strategy for Petroclival Men... pubmed: epilepsy treatmentHepatic encephalopathy... pubmed: sleep apneaMorphine alters respiratory c... Clinical Chemistry and Laboratory Medicine (CCLM... pubmed: "j inorg biochem"[jo...Anti-fibrotic act... pubmed: "bmc med educ"[jour]Assessment of third-y..."BMC Bioinformatics"[jour]; +18...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5...Atmosphere, Vol. 11, Pages 287: The Influence of ...Tumor-Associated Macrophages: Recent Insights and...Non-stationary statistics and formation jitter in...Exploiting TCR Recognition of Shared Hotspot Onco... Journal of Experimental & Clinical Cancer Resear... Surgical neurology internationalInfrared thermog...Preoperative and Postoperative Risk Stratificatio... The International Journal of Medical Robotics an... Future OncologyMIRROS: a randomized,...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,