Cancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of AgeCancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age Cancers doi: 10.3390/cancers12030712 Authors: Simon J. Johnston Binafsha M. Syed Ruth M. Parks Cíntia J. Monteiro Joseph A. Caruso Andrew R. Green Ian O. Ellis Kelly...
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Elevated Exhaled Nitric Oxide in Adolescents Is Associated With Incident Allergic Symptoms: A Prospective Cohort Study.Related ArticlesElevated Exhaled Nitric Oxide in Adolescents Is Associated With Incident Allergic Symptoms: A Prospective Cohort Study. J Investig Allergol Clin Immunol. 2019;29(3):231-238 Authors: Kalm-Stephens P, Nordvall L, Janson C, Neuman Å, Malinovschi A, Alving K Abstract BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation in the airways....
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Cancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of AgeCancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age Cancers doi: 10.3390/cancers12030712 Authors: Simon J. Johnston Binafsha M. Syed Ruth M. Parks Cíntia J. Monteiro Joseph A. Caruso Andrew R. Green Ian O. Ellis Kelly...
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Efficacy and safety of anlotinib, a multikinase angiogenesis inhibitor, in combination with epirubicin in preclinical models of soft tissue sarcomaSoft tissue sarcoma (STS) is a rare and diverse group of solid tumors with poor survival. For the first time, we showed that anlotinib, a multikinase angiogenesis inhibitor, combined with epirubicin was an effective and safe therapy in a sarcoma patient‐derived xenografts model, which suggested combined therapy drug as a promising therapeutic strategy...
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Percutaneous Venous Angioplasty in Patients with Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency: A Randomized Wait List Control Study.Related ArticlesPercutaneous Venous Angioplasty in Patients with Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency: A Randomized Wait List Control Study. Ann Vasc Surg. 2020 Jan;62:275-286 Authors: Napoli V, Berchiolli R, Carboncini MC, Sartucci F, Marconi M, Bocci T, Perrone O, Mannoni N, Congestrì C, Benedetti R, Morganti R, Caramella...
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Einleitung: 50 Jahre Difficile Liberté von Emmanuel Lévinasedoc: No conditions. Results ordered -Date Deposited.nowRezension zu: Medialisierungen des Unsichtbaren um 1900, hrsg. von Susanne Scholz, Julika Griem, München 2010edoc: No conditions. Results ordered -Date Deposited.nowMark above section as read Clinical EndocrinologySurveillance of succinate dehydrogenase gene mutation carriers: insights from a nationwide cohortABSTRACT Objective Mutations in the genes coding for succinate dehydrogenase...
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The survival impact of postoperative complications after curative resection in patients with esophageal squamous cell carcinoma: propensity score-matching analysisAbstract Purpose The relationship between postoperative complications and long-term survival after surgery for esophageal squamous cell carcinoma (ESCC) is controversial. Method A total of 210 patients with ESCC who underwent subtotal esophagectomy with a reconstructed gastric tube were investigated according to the development of postoperative...
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Transfer and loss of allergen‐specific responses via stem cell transplantation: a prospective observational studyABSTRACT Background Currently, no estimates can be made on the impact of hematopoietic stem cell transplantation on allergy transfer or cure of the disease. By using component‐resolved diagnosis we prospectively investigated fifty donor‐recipient pairs undergoing allogeneic stem cell transplantation. This allowed calculating the rate of transfer or maintenance of allergen‐specific responses...
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A Physicist for President?Recent events make it clear that it couldn't hurt to elect someone who applies the scientific method to thinking and decision making -- Read more on ScientificAmerican.comScientific American Blog Posts16hHow COVID-19 Is Like Climate ChangeBoth are existential challenges—and a president who belittles and neglects science has made them both tougher to address -- Read more on ScientificAmerican.comScientific American Blog Posts17hFlattening the COVID-19 CurvesSocial distancing...
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IJERPH, Vol. 17, Pages 1989: Concurrent and Convergent Validity of a Single, Brief Question for Physical Activity AssessmentIJERPH, Vol. 17, Pages 1989: Concurrent and Convergent Validity of a Single, Brief Question for Physical Activity Assessment International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061989 Authors: Antonio Moreno-Llamas Jesús García-Mayor Ernesto De la Cruz-Sánchez An extensive number of self-reported methods for physical activity (PA) measurement...
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Eye movements support behavioral pattern completion [Psychological and Cognitive Sciences]The ability to recall a detailed event from a simple reminder is supported by pattern completion, a cognitive operation performed by the hippocampus wherein existing mnemonic representations are retrieved from incomplete input. In behavioral studies, pattern completion is often inferred through the false endorsement of lure (i.e., similar) items as...Proceedings of the National Academy of Sciences current issue14hConnectivity...
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Regulatory effect of 17β‐estradiol on the expression of β‐defensin‐2 and proinflammatory cytokines in human oral epithelial cellsAbstract Background Although estrogen deficiency has been proposed as a risk factor for oral mucosal inflammatory diseases in post‐menopausal women, the mechanisms involved remain unclear. This study aimed to investigate the effect of 17β‐estradiol (E2) on the inflammatory response stimulated by interleukin‐1 beta (IL‐1β) in human oral mucosal epithelial cells (hOMECs)...
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Cancer Biotherapy & Radiopharmaceuticals - Table of ContentsPreclinical Single Photon Emission Computed Tomography of Alpha Particle-Emitting Radium-223Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.Cancer Biotherapy & Radiopharmaceuticals - Table of Contents11hMark above section as read Latest Results for CNS DrugsPharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic ReviewAbstract Background Stimulant drugs are second only to cannabis as the most...
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Select item 321769441.The effect of hyperbaric oxygen therapy on gene expression: microarray analysis on wound healing.Tlapák J, Chmátal P, Oniscenko B, Pavlík V, Dosel P, Páral J, Lochman P.Undersea Hyperb Med. 2020 First Quarter;47(1):31-37. PMID:32176944Similar articlesSelect item 321768392.Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children.Hodge S, Macowan M, Liu H, Hamon R, Chen AC, Marchant...
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Burn pit exposure in military personnel: is there an effect on sleep-disordered breathing?Abstract Purpose Exposure to elevated concentrations of respirable particulate matter (< 10 μm) may influence sleep-disordered breathing. Burn pits as utilized by the US military in the Middle East until 2011 produced elevated particle matter concentrations. We seek to determine if subjective exposure to burn pits during deployment affects prevalence or severity of obstructive sleep apnea (OSA) in military...
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Study protocol of a multicenter phase III randomized controlled trial investigating the efficiency of the combination of neoadjuvant chemotherapy (NAC) and neoadjuvant laparoscopic intraperitoneal hyperthermic chemotherapy (NLHIPEC) followed by R0 gastrectomy with intraoperative HIPEC for advanced gastric cancer (AGC): dragon II trial: Even though treatment modalities such as adjuvant systemic radio-chemotherapy and neoadjuvant chemotherapy (NAC) have individually have improved overall survival (OS)...
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Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma: Although checkpoint blockades have become widely used, the immunological impact in cancer patients, especially those with oral cavity squamous cell carcinoma (OCSCC), has not been well studied.
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IJMS, Vol. 21, Pages 2071: Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer's DiseaseIJMS, Vol. 21, Pages 2071: Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer's Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062071 Authors: Jia Xu Fang Wang Jiejie Guo Chunshuang Xu Yanzi Cao Zhiling Fang Qinwen Wang Alpinia oxyphylla Miq. (i.e., A. oxyphylla), a traditional Chinese...
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P16 as a marker of carcinoma in effusions and peritoneal washing: Considering the potential of p16 as a marker for diagnosis, prognosis and therapeutic response, the aim of this study was to assess its presence, via immunocytochemistry, in metastatic carcinoma of different p...
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Application of Double Hurdle Model on Effects of Demographics for Tea Consumption in ChinaThe purpose of this study is to investigate the effects of demographic variables on tea consumption in China. A total of 12,745 samples collected from the China Health and Nutrition Survey in 2011 and a double hurdle model were used to analyze the effects of demographic variables on the extent of tea participation and consumption quantity for men and women. The results of this study indicate that the effects...
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Acute Effects of Insulin on Cardiac Function in Patients with Diabetes Mellitus: Clinical Applicability and FeasibilityBackground. Insulin promotes glucose consumption as the main cardiac energy source, while increasing myocardial efficiency. The short-term effects of insulin on cardiac function and its potential curative role in an acute diabetological cardiology setting remain unknown. Our study evaluated the role of acute insulin administration in the diabetic heart, its corresponding effective...
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Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form: Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed...
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Top 5 applications of AR in orthopedic surgeryResearchers from Switzerland, Germany, and the U.S. have outlined the key applications...Read more on AuntMinnieEurope.comRelated Reading: Spanish team visualizes 3D patient models on smartphones Cardiac patients gain from 3D printing, AR advances Augmented reality can help guide aneurysm repair AR helps transform minimally invasive surgery Milan group uses AR, 3D printing to assist in heart surgeryAuntMinnieEurope.com Headlines2mMark above section as...
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Behcet's Disease with Upper GI Bleeding: Introduction. Behcet's disease is a multisystem disease. In sub-Saharan Africa, the prevalence of this disease is not known, with only one case report from Ethiopia. Case Presentation. We describe a case of a 29-year-old Ethiopian male who presented to the emergency room of Tikur Anbessa specialized hospital with 4 days history of back pain, recurrent history of oral and genital ulcers, right eye blindness, chronic cerebral vein thrombosis, gastrointestinal...
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Shear Wave Elastography versus Strain Elastography in Diagnosing Parathyroid Adenomas: Objectives. The aim of the study was to compare elastographic means in parathyroid adenomas, using shear wave elastography and strain elastography. Methods. This prospective study examined 20 consecutive patients diagnosed with primary hyperparathyroidism and parathyroid adenoma, confirmed by biochemical assay, technetium-99 sestamibi scintigraphy, and pathology report, after parathyroid surgery. All patients were...
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Development and Validation of a Five‐Gene Model to Predict Postoperative Brain Metastasis in Operable Lung AdenocarcinomaOne of the most common sites of extra‐thoracic distant metastasis of non‐small‐cell lung cancer is the brain. This study was performed to discover genes associated with postoperative brain metastasis in operable lung adenocarcinoma (LUAD). RNA seq was performed in specimens of primary LUAD from seven patients with brain metastases and 45 patients without recurrence. Immunohistochemical...
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How to preserve the olfaction in harvesting the nasoseptal flap in endoscopic skull base surgery.: The introduction of nasoseptal flap for the skull base defects reconstruction in endoscopic endonasal approaches represents a revolution that dramatically reduced incidence of the cerebrospinal fluid leaks, however it may be associated with comorbidities like olfactory hypofunction. Objectives: We revise our anatomical knowledge and surgical experience in order to describe an easy and safe technique...
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The safety and efficacy of immune checkpoint inhibitors in patients with advanced cancers and pre-existing chronic viral infections (Hepatitis B/C, HIV): a review of the available evidence: Over the last decade immunotherapy has revolutionized the treatment of many cancers, especially with the better understanding of molecular biology and immunology. Programmed death 1 (PD-1) is an inhibitory cell-surface receptor expressed on the surface of T cells, B cells, and natural-killer cells. The effector...
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Spontaneous Bacteroides fragilis spondylodiscitis in an elderly ladyA 76-year-old woman presented following two episodes of unexplained falls at home. Blood cultures were positive for Bacteroides fragilis and following investigations she was diagnosed with L4/L5 spondylodiscitis confirmed on spine MRI. She was initially treated with intravenous metronidazole and flucloxacillin prior to switching to ceftriaxone with good results. No primary cause of B. fragilis bacteraemia was found in this case....
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HHV-6: an unusual cause of cerebellar ataxia: Human herpesvirus 6 (HHV-6) infection is the cause of roseola infantum in children. The reactivation of HHV-6 is associated with multiple clinical syndromes including encephalitis and myelitis, especially in haematopoietic stem cell transplant recipients. However, the virus can cause encephalitis in other immunosuppressed as well as immunocompetent individuals. We report a case of a 70-year-old woman who was immunocompromised secondary to treatment of...
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Aspergillus niger fungemia secondary to chronic pulmonary aspergillosis in a patient with invasive squamous cell carcinomaBMJ Case Reports Last 6 Issues3hType B lactic acidosis due to Warburg effect in a child presenting with T cell acute lymphoblastic leukaemia: a milder phenotypeLactic acidosis (LA) is characterised by persistently increased blood lactate >5 mmol/L. Type A LA due to anaerobic glycolysis is frequently seen during management of haematological malignancies. A rare form of LA known...
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No lesion? No problem: case of oesophageal lichen planus in a patient without any cutaneous lesions: Oesophageal lichen planus (ELP) is an uncommon presentation of mucocutaneous lichen planus. Due to its rare nature, it can often be misdiagnosed. As such, there can be a significant delay between symptom onset and diagnosis. ELP drastically reduces quality of life secondary to the severe dysphagia and odynophagia that typically accompany this pathogenesis. Additionally, it is important to diagnose...
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Rare gain of chromosome 5 in a supratentorial hemispheric paediatric pilomyxoid astrocytomaBMJ Case Reports Last 6 Issues3hAspergillus niger fungemia secondary to chronic pulmonary aspergillosis in a patient with invasive squamous cell carcinomaBMJ Case Reports Last 6 Issues3hType B lactic acidosis due to Warburg effect in a child presenting with T cell acute lymphoblastic leukaemia: a milder phenotypeLactic acidosis (LA) is characterised by persistently increased blood lactate >5 mmol/L. Type...
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Acute myocardial infarction caused by persistent coronary spasm associated with high-grade macrophage accumulation: The mechanisms responsible for persistent and lethal coronary spasm remain incompletely understood. Our group treated a patient with non-ST-elevation myocardial infarction (MI) caused by a spontaneously persistent spasm associated with high-grade macrophage accumulation. A 48-year-old man was transferred to an emergency room because of persisted chest tightness. The patient's chest...
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Wiederbesiedlung von Quellen im Südschwarzwald nach einem AustrocknungsereignisDurch die Bohrung eines Sondierstollens während der Planung eines Pumpspeicherkraftwerks im Südschwarzwald kam es zu einem starken Bergwassereinfall, infolgedessen umliegende Quellen trocken fielen. Die Quellen des Quellkomplexes „Möslequellen" sprangen nach fast einem Jahr im Frühjahr 2012 wieder an. In dieser Studie wurde die Wiederbesiedlung dieser Quellen über drei Jahre verfolgt. Es zeigte sich, dass sich die Quellfauna...
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The safety and efficacy of immune checkpoint inhibitors in patients with advanced cancers and pre-existing chronic viral infections (Hepatitis B/C, HIV): a review of the available evidenceOver the last decade immunotherapy has revolutionized the treatment of many cancers, especially with the better understanding of molecular biology and immunology. Programmed death 1 (PD-1) is an inhibitory cell-surface receptor expressed on the surface of T cells, B cells, and natural-killer cells. The effector...
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Assessment of thyroid gland elasticity with shear-wave elastography in Hashimoto's thyroiditis patients: AbstractPurposeWe aimed to investigate the use and effectiveness of Shear-Wave Elastography (SWE) in Hashimoto's Thyroiditis (HT) diagnosis and compare the SWE values in HT patients with asymptomatic volunteers.MethodsThe thyroid gland parenchyma of 74 patients whose clinical and laboratory findings and ultrasonography (US) features were indicative of HT and 75 healthy, asymptomatic participants...
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Third‐wave cognitive behaviour therapies for weight management: A systematic review and network meta‐analysisSummary This systematic review and network meta‐analysis synthesized evidence on the effects of third‐wave cognitive behaviour therapies (3wCBT) on body weight, and psychological and physical health outcomes in adults with overweight or obesity. Studies that included a 3wCBT for the purposes of weight management and measured weight or body mass index (BMI) pre‐intervention and ≥ 3 months post‐baseline...
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Neuro-Oncology, T-Cell based therapies for overcoming neuroanatomical and immunosuppressive challenges within the glioma microenvironmentAbstract Glioblastoma remains as the most common and aggressive primary adult brain tumor to date. Within the last decade, cancer immunotherapy surfaced as a broadly successful therapeutic approach for a variety of cancers. However, due to the neuroanatomical and immunosuppressive nature of malignant gliomas, conventional chemotherapy and radiotherapy treatments...
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Systematic review of thromboprophylaxis in patients having orthognathic surgery: Orthognathic surgery is an elective procedure that is done in healthy individuals so complications such as thromboembolic events are rare. Pharmacological thromboprophylaxis, which reduces the risk of these events, may also increase blood loss and potentially the risk of life-threatening haemorrhage, so a state of clinical equipoise exists about whether it should be given routinely. We systematically reviewed published...
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Birmingham mandible and midface rules: determining variables for inclusion in a clinical predictor rule: Staff in emergency departments often rely on heuristics and algorithms to make clinical decisions on a wide range of problems. Clinical predictor rules such as the Ottawa ankle rules serve to reduce the need for unnecessary radiographs and help to give frontline staff the confidence to make a diagnosis. The current study aimed to achieve consensus on the variables to test for inclusion in a set...
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Primary lacrimal sac diffuse large B-cell lymphoma in a child.: Related ArticlesPrimary lacrimal sac diffuse large B-cell lymphoma in a child.J AAPOS. 2019 02;23(1):53-55Authors: Parikh D, Rodgers R, Kodsi SAbstract We report the case of a 13-year-old boy who presented with a 2-month history of left eyelid swelling, ecchymosis, and epiphora. Magnetic resonance imaging revealed a lobulated lesion in the region of the left lacrimal sac extending to the left nasolacrimal duct. Biopsy revealed...
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Intraoral Cutaneous Hamartomas-Clinicopathologic and Immunohistochemical Characteristics of 3 Cases.
Intraoral Cutaneous Hamartomas-Clinicopathologic and Immunohistochemical Characteristics of 3 Cases.: Related ArticlesIntraoral Cutaneous Hamartomas-Clinicopathologic and Immunohistochemical Characteristics of 3 Cases.Am J Dermatopathol. 2019 Nov;41(11):794-798Authors: Wilkinson PE, Gopalakrishnan R, Argyris PPAbstract Intraoral cutaneous hamartomas (ICHs) are uncommon mucosal lesions characterized microscopically by a combination of cutaneous structures, including various stages of follicular...
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Management of choroid plexus tumors-an institutional experience.: Related ArticlesView allThe choroid plexus is a plexus of cells that produces the cerebrospinal fluid in the ventricles of the brain. The choroid plexus consists of modified ependymal cells.Latin: Plexus choroideusManagement of choroid plexus tumors-an institutional experience.Acta Neurochir (Wien). 2019 04;161(4):745-754Authors: Hosmann A, Hinker F, Dorfer C, Slavc I, Haberler C, Dieckmann K, Knosp E, Czech TAbstract BACKGROUND:...
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[Carcinoma cuniculatum: An unusual oral tumor].: Related Articles[Carcinoma cuniculatum: An unusual oral tumor].Ann Pathol. 2019 Sep;39(5):369-373Authors: Ben Arfi K, Marchal A, Hafian H, Boulagnon-Rombi CAbstract We report on a case of carcinoma cuniculatum (CC) of the maxillary gingival mucosa. A 60-year-old woman presented with an exophytic gingivo-palatal mass with slow growth and osteolytic evolution. A first performed biopsy was negative for malignancy. The diagnosis of CC was established...
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[Carcinoma cuniculatum: An unusual oral tumor].: Related Articles[Carcinoma cuniculatum: An unusual oral tumor].Ann Pathol. 2019 Sep;39(5):369-373Authors: Ben Arfi K, Marchal A, Hafian H, Boulagnon-Rombi CAbstract We report on a case of carcinoma cuniculatum (CC) of the maxillary gingival mucosa. A 60-year-old woman presented with an exophytic gingivo-palatal mass with slow growth and osteolytic evolution. A first performed biopsy was negative for malignancy. The diagnosis of CC was established...
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Isolated unilateral sixth nerve palsy in a patient with nasopharyngeal carcinoma.: Related ArticlesIsolated unilateral sixth nerve palsy in a patient with nasopharyngeal carcinoma.Rom J Ophthalmol. 2019 Oct-Dec;63(4):375-378Authors: Aghdam KA, Zand A, Sanjari MSAbstract Objective: To describe an isolated unilateral sixth nerve palsy, as a rare neuro-ophthalmic presentation of nasopharyngeal carcinoma. Methods: We report a 54-year-old female, known case of nasopharyngeal carcinoma who was...
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Adjusting ADJUST: Optimizing the ADJUST algorithm for pediatric data using geodesic netsAbstract A major challenge for electroencephalograph (EEG) studies on pediatric populations is that large amounts of data are lost due to artifacts (e.g., movement and blinks). Independent component analysis (ICA) can separate artifactual and neural activity, allowing researchers to remove such artifactual activity and retain a greater percentage of EEG data for analyses. However, manual identification of artifactual...
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Evidence for associations between Th1/Th17 "hybrid" phenotype and altered lipometabolism in very severe Graves' orbitopathy.: Related ArticlesEvidence for associations between Th1/Th17 "hybrid" phenotype and altered lipometabolism in very severe Graves' orbitopathy.J Clin Endocrinol Metab. 2020 Mar 16;:Authors: Fang S, Zhang S, Huang Y, Wu Y, Lu Y, Zhong S, Liu X, Wang Y, Li Y, Sun J, Gu P, Zhou H, Fan XAbstract PURPOSE: To investigate the characteristics of Th1 and Th17 cell lineages for...
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Assessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma.: Related ArticlesAssessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma.Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar 13;:Authors: Daskalopoulos AG, Avgoustidis D, Chaisuparat R, Karanikou M, Lazaris AC, Sklavounou A, Nikitakis NGAbstract...
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Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo.: Related ArticlesChemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo.Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar 13;:Authors: Al-Koshab M, Alabsi AM, Bakri MM, Naicker MS, Seyedan AAbstract OBJECTIVE: The aim of this study was to evaluate the chemopreventive activity of Malaysian jungle Tualang honey (TH) after oral carcinogenesis induced with 4-nitroquinoline...
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Ligneous gingivitis secondary to plasminogen deficiency: a multidisciplinary diagnostic challenge.: Related ArticlesLigneous gingivitis secondary to plasminogen deficiency: a multidisciplinary diagnostic challenge.Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar 12;:Authors: MacPherson M, Pho M, Cox J, Armstrong J, Darling MR, McCord CAbstract Plasminogen deficiency is a genetic condition resulting in deposition of extravascular fibrin within mucosal tissues. Lesions associated with plasminogen...
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Epithelioid rhabdomyosarcoma: report of the first case in the jaw.: Related ArticlesEpithelioid rhabdomyosarcoma: report of the first case in the jaw.Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar 12;:Authors: de Aguiar MCF, de Noronha MS, Silveira RL, Araújo JAD, Werkema FS, Bell D, Caldeira PCAbstract OBJECTIVES: Epithelioid rhabdomyosarcoma (EpiRMS) is a novel morphologically distinct variant of rhabdomyosarcoma, with an unusually challenging microscopic diagnosis. The occurrence...
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Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.Related ArticlesCa2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. Cell Physiol Biochem. 2020 Mar 17;54(2):252-270 Authors: Bhardwaj R, Augustynek BS, Ercan-Herbst E, Kandasamy P, Seedorf M, Peinelt C, Hediger MA Abstract BACKGROUND/AIMS: Store-operated Ca2+ entry (SOCE) through plasma membrane Ca2+ channel Orai1...
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Cancers, Vol. 12, Pages 710: Cancer Genetics and Therapeutic Opportunities in Urologic PracticeCancers, Vol. 12, Pages 710: Cancer Genetics and Therapeutic Opportunities in Urologic Practice Cancers doi: 10.3390/cancers12030710 Authors: Jacob J. Adashek Alex Leonard Jason Roszik Arjun K. Menta Giannicola Genovese Vivek Subbiah Pavlos Msaouel This article aims to summarize the current literature on genetic alterations related to tumors of the genitourinary tract. Novel associations have recently been...
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Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.Related ArticlesChanges in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia. PLoS One. 2019;14(9):e0221591 Authors: Oosterom N, de Jonge R, Smith DEC, Pieters R, Tissing WJE, Fiocco M, van Zelst BD, van den Heuvel-Eibrink MM, Heil SG Abstract BACKGROUND: Methotrexate...
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Epilepsy in Papua New Guinea: a longitudinal cohort study.Related ArticlesEpilepsy in Papua New Guinea: a longitudinal cohort study. Arch Dis Child. 2019 10;104(10):941-946 Authors: Mond C, Duke T, Vince J Abstract Epilepsy affects up to 1-4% of children living in low income and middle countries, however there are few studies of the problems faced by children with epilepsy in such settings. We aimed to document the situation for children with epilepsy in Port Moresby, an urban area in Papua New Guinea,...
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A Novel Laryngoscope With an Adjustable Distal Tip.Related ArticlesA Novel Laryngoscope With an Adjustable Distal Tip. Laryngoscope. 2020 Mar 16;: Authors: Honeybrook A, Lee W, Cohen S Abstract OBJECTIVES: Various laryngoscopes are currently available for supraglottic, glottic, and cervical esophageal exposure, yet none allow for adjustable articulation of the laryngoscope distal tip. We sought to create a new laryngoscope to improve anatomic field of view exposure. STUDY DESIGN: Novel laryngoscope...LarynxTue...
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Trends in Age of Cochlear Implant Recipients, and the Impact on Perioperative Complication Rates.Related ArticlesTrends in Age of Cochlear Implant Recipients, and the Impact on Perioperative Complication Rates. Otol Neurotol. 2020 Apr;41(4):438-443 Authors: Fakurnejad S, Vail D, Song Y, Alyono J, Blevins NH Abstract OBJECTIVE: The aim of the study is to examine trends in the age of patients receiving cochlear implants and to determine the effect of age on the rate of perioperative complications....
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Psychometric properties of the Patient‐Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance and Sleep‐Related Impairment item banks in adolescentsAbstract Sleep problems have a high prevalence and negative daytime consequences in adolescents. Current sleep measures for this age group have limitations. The Patient‐Reported Outcomes Measurement Information System (PROMIS®) developed sleep item banks for adults. In a previous validation study, these item banks were adapted to...
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Overexpression of Myo1e promotes albumin endocytosis by mouse glomerular podocytes mediated by DynaminBackground As a fundamental process internalizing molecules from the plasma membrane, endocytosis plays a crucial role in podocyte biology. Our previous study has identified that overexpression of Myole may enhance podocyte endocytosis. However, its potential mechanism has been not well understand. Thus, we aimed to analyze whether albumin endocytosis by mouse glomerular podocytes is dependent on...
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Why some size illusions affect grip apertureAbstract There is extensive literature debating whether perceived size is used to guide grasping. A possible reason for not using judged size is that using judged positions might lead to more precise movements. As this argument does not hold for small objects and all studies showing an effect of the Ebbinghaus illusion on grasping used small objects, we hypothesized that size information is used for small objects but not for large ones. Using a modified...
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Gating mechanism of hyperpolarization-activated HCN pacemaker channelsNature Communications - current - nature.com science feedsTue Mar 17, 2020 02:00Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1Nature Communications - current - nature.com science feedsTue Mar 17, 2020 02:00A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancerNature Communications - current - nature.com science feedsTue Mar 17, 2020...
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Neuronavigation in the Identification and Presurgical Planning of Cortical Focal Dysplasia [LETTERS]American Journal of Neuroradiology current issueTue Mar 17, 2020 19:17Reduction of Radiation Dose and Scanning Time While Preserving Diagnostic Yield: A Comparison of Battery-Powered and Manual Bone Biopsy Systems [INTERVENTIONAL]BACKGROUND AND PURPOSE:There is scarcity of data on the comparative efficacy between bone biopsy drill systems across various types of bone lesions. Our aim was to investigate...
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A GWAS identifies FSHR rs2300441 associated with Follicle‐stimulating Hormone levelsAbstract Follicle stimulating hormone (FSH) and luteinizing hormone (LH) play critical roles in female reproduction, while the underlying genetic basis is poorly understood. GWASs of FSH and LH levels were conducted in 2590 Chinese females including 1882 PCOS cases and 708 controls. GWAS for FSH level identified multiple variants at FSHR showing genome‐wide significance with the top variant (rs2300441) located in...
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71.Int J Surg Case Rep. 2020 Mar 3;68:185-189. doi: 10.1016/j.ijscr.2020.02.062. [Epub ahead of print]Gastric inflammatory myofibroblastic tumor in a 10-month-old girl: A case report.Morales Prillwitz O1, Pérez Hurtado B2, Olaya Álvarez S3, Arevalo Sánchez NM3, Astudillo Palomino RE4.Author informationAbstractINTRODUCTION:Inflammatory Myofibroblastic Tumors (IMTs) are rare mesenchymal tumors of unclear etiology and uncertain malignant potential that affect all age groups. IMTs are most often found...
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36.J Craniofac Surg. 2020 Mar 13. doi: 10.1097/SCS.0000000000006313. [Epub ahead of print]Gelatin Sponge Induced Maxillary Sinusitis After Transsphenoidal Pituitary Surgery.Lee DH1, Yoon TM, Lee JK, Lim SC.Author informationAbstractTranssphenoidal pituitary surgery is a safe, well-established treatment method, but it is associated with several postoperative nasal complications. However, gelatin sponge induced maxillary sinusitis after transsphenoidal pituitary surgery has not been reported. In this...
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1.PLoS Pathog. 2020 Mar 16;16(3):e1008447. doi: 10.1371/journal.ppat.1008447. [Epub ahead of print]STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.Wang Y1, Du S1, Zhu C1, Wang C1, Yu N1, Lin Z1, Gan J1,2, Guo Y3, Huang X4, He Y4, Robertson E5, Qu D1, Wei F2, Cai Q1,6.Author informationAbstractLatent Epstein-Barr virus (EBV) infection is strongly associated with several malignancies, including B-cell lymphomas and epithelial tumors. EBNA1 is a key antigen...
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.Front Oncol. 2020 Feb 27;10:112. doi: 10.3389/fonc.2020.00112. eCollection 2020.Xi X1, Gao L2, Wu Q2,3, Fang S3, Xu J4, Liu R2, Yang X2, Zhu S2, Zhao R2, Lai X2, Zhang X2, Zhang B1,2, Jiang Y2.Author informationAbstractAccording to the 2015 American Thyroid Association (ATA), referred risk stratification and thyroid nodules with intermediate- and low-suspicion patterns are difficult to diagnose. The objective of this study is to evaluate the diagnostic performance of contrast-enhanced ultrasonography...
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1.Front Oncol. 2020 Feb 26;10:131. doi: 10.3389/fonc.2020.00131. eCollection 2020.Real-World Impact of Surgical Excision on Overall Survival in Primary Central Nervous System Lymphoma.Deng X1, Xu X2, Lin D1, Zhang X1, Yu L1, Sheng H1, Yin B1, Zhang N1, Lin J1.Author informationAbstractSubstantial controversy still exists regarding the use of surgical excision in the treatment of primary central nervous system lymphoma (PCNSL). This study was aimed to evaluate the survival benefit of surgical excision...
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P18 A human and translational study of severe white matter damage in SHANK3 deficiencyPublication date: April 2020Source: Clinical Neurophysiology, Volume 131, Issue 4Author(s): S. Jesse, H.P. Müller, M. Schoen, H.J. Huppertz, V. Rasche, A.C. Ludolph, T.M. Boeckers, J. KassubekClinical NeurophysiologyTue Mar 17, 2020 22:26P17 MRI volumetry and microtexture analysis of focal alterations of the callosal area III in primary lateral sclerosisPublication date: April 2020Source: Clinical Neurophysiology,...
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P58 Mechanisms of Temporal Interference (TI) stimulationPublication date: April 2020Source: Clinical Neurophysiology, Volume 131, Issue 4Author(s): Z. Esmaeilpour, G. Kronberg, L.C. Parra, M. BiksonClinical NeurophysiologyTue Mar 17, 2020 22:26P57 Investigating the Role of the Primary Motor Cortex in Upper Limb FreezingPublication date: April 2020Source: Clinical Neurophysiology, Volume 131, Issue 4Author(s): M. Topka, M. Scholten, C. Zrenner, P. Belardinelli, U. Ziemann, D. WeissClinical NeurophysiologyTue...
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Multi-scale resting state functional reorganization in response to multiple sclerosis damageAbstract Purpose In multiple sclerosis (MS), how brain functional changes relate to clinical conditions is still a matter of debate. The aim of this study was to investigate how functional connectivity (FC) reorganization at three different scales, ranging from local to whole brain, is related to tissue damage and disability. Methods One-hundred-nineteen...Neuroradiology02:00Mark above section as read Clinical...
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The latest on COVID-19, from social-distancing to US casesHand washing is still our best defense. (Unsplash/)Follow all of PopSci's COVID-19 coverage here, including travel advice, pregnancy concerns, and the latest findings on the virus itself.The novel coronavirus first identified in Wuhan, China in December 2019 is now spreading extensively throughout communities in the United States and has reached global pandemic status. We've collected some of the latest news and findings on COVID-19 to inform...
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Hidradenitis suppurativa associated with pazopanibWiley: Dermatologic Therapy: Table of Contents03:16Comparative study of the efficacy and safety of secukinumab vs ixekizumab in moderate‐to‐severe psoriasis after one‐year of treatment: real‐world practiceABSTRACT There are no studies which directly compare efficacy in PASI response of secukinumab and ixekizumab. The main aim of this study was to compare the efficacy and safety of both drugs used to treat moderate‐to‐severe psoriasis patients over...
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Ancient hornwort genomes could lead to crop improvementAn international research team illuminates the origin of land plants by analyzing the first hornwort genomes. In this ancient group of land plants, they discovered genes that could help crops grow more efficiently with less synthetic fertilizer.Evolutionary Biology News -- ScienceDailyMon Mar 16, 2020 20:14Mark above section as read Latest Results for MedicalFlatness of musculoskeletal systems under functional electrical stimulationAbstract Control...
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Fasciola hepatica: the dispersal of cercariae shed by the snail Galba truncatulaAuthors: Daniel Rondelaud, Philippe Vignoles and Gilles Dreyfuss.<br />Parasite Vol. 27 , page 17<br />Published online: 18/03/2020<br /> Keywords: Fasciola hepatica ; Limousin ; Metacercaria ; Nasturtium officinale ; Watercress bed.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/fSUoZ8fDts8" height="1" width="1" alt=""/>Parasite02:00Oral migration of Dirofilaria repens after creeping...
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Pathogens, Vol. 9, Pages 221: Free to Circulate: An Update on the Epidemiological Dynamics of Porcine Circovirus 2 (PCV-2) in Italy Reveals the Role of Local Spreading, Wild Populations, and Foreign CountriesPathogens, Vol. 9, Pages 221: Free to Circulate: An Update on the Epidemiological Dynamics of Porcine Circovirus 2 (PCV-2) in Italy Reveals the Role of Local Spreading, Wild Populations, and Foreign Countries Pathogens doi: 10.3390/pathogens9030221 Authors: Franzo Tinello Grassi Tucciarone Legnardi...
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Microorganisms, Vol. 8, Pages 422: Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence AnalysisMicroorganisms, Vol. 8, Pages 422: Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis Microorganisms doi: 10.3390/microorganisms8030422 Authors: Konduri Ranjith Chinthala Reddy SaiAbhilash Gumpili Sai Sai Prashanthi Shalem Raj Padakandla Savitri Sharma Sisinthy Shivaji Escherichia coli is a predominant bacterium in the intestinal...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 2062: Candidate Genes for Freezing and Drought Tolerance Selected on the Basis of Proteome Analysis in Doubled Haploid Lines of BarleyIJMS, Vol. 21, Pages 2062: Candidate Genes for Freezing and Drought Tolerance Selected on the Basis of Proteome Analysis in Doubled Haploid Lines of Barley International Journal of Molecular Sciences doi: 10.3390/ijms21062062 Authors: Wójcik-Jagła Rapacz Dubas Krzewska Kopeć Nowicka Ostrowska Malaga Żur...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 1978: Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score AnalysisIJERPH, Vol. 17, Pages 1978: Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061978 Authors: Kiyon Rhew Joshua D Brown Jung Mi Oh Atopic disease is associated with chronic...
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Antibiotics, Vol. 9, Pages 126: Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from IndonesiaAntibiotics, Vol. 9, Pages 126: Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia Antibiotics doi: 10.3390/antibiotics9030126 Authors: Gian Primahana Chandra Risdian Tjandrawati Mozef Enge Sudarman Matthias Köck Joachim Wink Marc Stadler During the course of our ongoing screening for novel biologically...
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Cancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E...Elevated Exhaled Nitric Oxide in Adolescents Is A...Cancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E...Efficacy and safety of anlotinib, a multikinase a...Percutaneous Venous Angioplasty in Patients with ...Einleitung: 50 Jahre Difficile Liberté von Emmanu...The survival impact of postoperative complication...Transfer and loss of allergen‐specific responses ...A Physicist for President?Recent events make it c...IJERPH, Vol. 17, Pages 1989: Concurrent...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,