SummaryFamilial partial lipodystrophy type 2 (FPLD2) is characterized by insulin resistance, adipose atrophy of the extremities, and central obesity. Due to the resemblance with Cushing′s syndrome, we hypothesized a putative role of glucocorticoid in the pathogenesis of metabolic abnormalities in FPLD2.ObjectiveTo evaluate the phenotypic heterogeneity and glucocorticoid sensitivity in FPLD2 patients exhibiting the p.R482W or p.R644C LMNA mutations.Design, patients, measurementsProspective...
Sat Apr 06, 2019 12:10
SummaryobjectiveWe studied cardiac autonomic changes in relation to metabolic factors, body composition and 24hour ambulatory blood pressure measurements in Turner syndrome patients without known hypertension.DesignCross sectional.PatientsParticipants were 48 TS women and 24 healthy female controls aged over 18 years.MethodsShort‐term power spectral analysis was obtained in supine‐standing‐supine position. Bedside tests included three conventional cardiovascular reflex tests of heart rate...
Sat Apr 06, 2019 12:09
Abstract Purpose The overdiagnosis of thyroid nodules and indolent thyroid cancers represents an increasing burden on health services, with thyroid ultrasound (US) imaging often representing the initial entry point into the thyroid nodule diagnostic pathway. The aim of this study was to retrospectively review thyroid US referrals to a single Irish hospital to determine if the stated indications...
Sat Apr 06, 2019 03:00
Abstract Purpose To evaluate the effect of oral alpha-lipoic acid (ALA) ± palmitoyl-ethanolamide (PEA) on neuropathic symptoms in patients with diabetic peripheral neuropathy (DPN) and to identify factors related to the efficacy of the treatment. Methods This is a retrospective observational pilot study evaluating 49 patients with diabetes and positive Neuropathy...
Thu Apr 04, 2019 03:00
Abstract Purpose Recently, it has been confirmed that circulating miRNAs play an important role in disease pathogenesis and can be biomarkers of many autoimmune diseases. However, the knowledge about circulating miRNAs in Graves' disease (GD) is very limited. In this study, we aimed to identify circulating miRNAs as potential biomarkers of GD. Methods We...
Thu Apr 04, 2019 03:00
Abstract Objective This study aimed to investigate the effects of liraglutide on bone metabolism markers in rat models with glucocorticoid-induced osteoporosis (GIOP), including the effects on bone mass, bone tissue microstructure, bone biomechanics, and bone turnover markers. Method Thirty male Sprague–Dawley rats aged 8 weeks were randomly divided into...
Sat Apr 06, 2019 03:00
Abstract Purpose We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). Methods We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular events (MACE) risk by stratifying...
Sat Apr 06, 2019 03:00
Abstract Purpose Varicocele repair (VR) is proposed to improve fertility in subfertile couples with a poor semen quality. We explored whether the disappearance of a left continuous spermatic venous reflux (SVR) at scrotal colour-Doppler ultrasound (CDUS), an objective evidence for a VR, is predictive for improved fertility outcome in subfertile couples. Methods ...
Sat Apr 06, 2019 03:00
Abstract Purpose In recent years, an increasing number of specialized gender clinics have been prescribing gonadotropin-releasing hormone (GnRH) analogs to adolescents diagnosed with gender dysphoria (GD) to suppress puberty. This paper presents qualitative research on the hormone therapy (HT) experiences of older trans-people and their views on puberty suppression. The main aim of this research was to explore the psychological aspects...
Fri Apr 05, 2019 03:00
Fri Apr 05, 2019 03:00
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Sat Apr 06, 2019 02:11
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,