The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway, Published online: 08 February 2019; doi:10.1038/s41467-019-08418-4

How the chromosome passenger complex (CPC) phosphorylates the kinetochores that can be a micron away to control mitotic events is unknown. Here the authors find that the CPC directly binds microtubules near inner centromeres, which controls its ability to phosphorylate kinetochores independently of tension generated by kinetochore microtubule attachments.

from A via a.sfakia on Inoreader https://go.nature.com/2GiYvdK