Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions, Published online: 08 February 2019; doi:10.1038/s41467-019-08604-4

Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an 'innateness gradient' that is associated with changes in proliferation and effector functions.

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