Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis

Pathogenic function of bystander-activated memory-like CD4⁺ T cells in autoimmune encephalomyelitis

Pathogenic function of bystander-activated memory-like CD4⁺ T cells in autoimmune encephalomyelitis, Published online: 12 February 2019; doi:10.1038/s41467-019-08482-w

T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmunity.

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