Metal‐Catalyzed Sequential Formation of Distant Bonds in Organic Molecules: Palladium‐Catalyzed Hydrosilylation/Cyclization of 1,n‐Dienes via Chain Walking

Sequential formation of distant bonds in organic molecules was achieved for the palladium‐catalyzed hydrosilylation/cyclization of various 1,n‐dienes via chain walking of the metal catalyst. The reaction was found applicable to various 1,n‐dienes including a 1,13‐diene to form a cyclopentane ring as well as a carbon‐silicon bond at a remote site. The use of "nondissociative" chain walking provides a fascinating strategy in organic synthesis to functionalize distant parts of organic molecules in a particular order within a catalytic cycle by effectively moving the reactive center from a remote position.

from A via a.sfakia on Inoreader http://bit.ly/2BvXcnW