Phototriggered release of transmembrane chloride carrier from an o‐nitrobenzyl‐linked procarrier

While there have been tremendous studies about synthetic chloride carriers and their recent application in the apoptotic cell death, so far the proposed huge potential of these systems in targeting cancer has not been materialized due to their cytotoxicity to healthy cells as well. Herein, we describe the development of an indole‐2‐carboxamide receptor as an efficient transmembrane chloride carrier while the corresponding o‐nitrobenzyl‐linked derivative is a procarrier of ion. Photoirradiation of the procarrier in lyposomes results in the release of the active carrier displaying up to 90% transport efficiency. Such photorelease of the active carrier also works within cancer cells and the process resulted in efficient cell death. All in all, such photocleavable procarriers have great potential as a photodynamic therapy to combat various types of cancers.

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