Digital Phenotyping in Patients with Spine Disease: A Novel Approach to Quantifying Mobility and Quality of Life.

Digital Phenotyping in Patients with Spine Disease: A Novel Approach to Quantifying Mobility and Quality of Life.

World Neurosurg. 2019 Feb 21;:

Authors: Cote DJ, Barnett I, Onnela JP, Smith TR

Abstract
OBJECTIVE: To identify trends in mobility and daily pain levels among a cohort of patients with clinically diagnosed spine disease.
METHODS: Participants with spine disease were enrolled from a general neurosurgical clinic and installed a smartphone application (BeiweTM) designed for digital phenotyping to their personal smartphone. This application collected passive meta-data on a minute-to-minute basis, including GPS, WiFi, accelerometer, text and phone logs, and screen on/off time. The application also administered daily Visual Analogue Scale pain surveys. A Linear Mixed Model framework was used to test for associations between self-reported pain and mobility/sociability from passively collected data.
RESULTS: 105 patients were enrolled with a median follow-up time of 94.5 days; 55 patients underwent a surgical intervention during follow up. Weekly pain survey response rate was 73.2%. By the end of follow up, the mean change in pain for all patients was -1.3 points (4.96 at the start of follow up to 3.66 by the end of follow up). Increased pain was significantly associated with reduced patient mobility as measured by three daily GPS summary statistics (average flight length, maximum diameter travelled, total distance travelled).
CONCLUSIONS: Patients with spine disease who report higher pain have reduced mobility as measured by passively collected smartphone GPS data. Smartphone-based digital phenotyping appears to be a promising and scalable approach to assess mobility and quality of life in patients with spine disease.

PMID: 30797933 [PubMed - as supplied by publisher]

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