Development of α‐Gal Antibody Conjugates for Increasing Immune Response by Recruiting Natural Antibodies

Cancer treatment with antibody (Ab) is one of the most successful therapeutic strategies for obtaining high selectivity. In this study, we developed α‐gal Ab conjugates that dramatically increased cellular cytotoxicity by recruiting natural Ab through α‐gal/anti‐Gal Abs interaction. The potency of α‐gal Ab conjugates depended on the α‐gal loading ratio. The larger the amount of α‐gal was introduced, the higher the cytotoxicity was observed. Utilization of α‐gal dendrimer allowed introduction of large amounts of α‐gal epitope to the Ab without loss of affinity for the target cell. The method described here will enable re‐development of Abs to improve their potency.

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