STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival.

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STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival.

Future Oncol. 2018 Sep;14(22):2253-2263

Authors: Huang N, Lin W, Shi X, Tao T

Abstract
AIM: To explore the independent prognostic value of STK24 expression in terms of overall survival and recurrence-free survival and the potential mechanisms of its dysregulation in non-small-cell lung adenocarcinoma.
PATIENTS & METHODS: Data were from the Cancer Genome Atlas-lung adenocarcinoma.
RESULTS: Increased STK24 expression was an independent prognostic indicator of unfavorable overall survival (Hazard ratio: 1.478; 95% CI: 1.149-1.901; p < 0.002) and recurrence-free survival (Hazard ratio: 1.855; 95% CI: 1.399-2.458; p < 0.001). DNA amplification was associated with significantly upregulated STK24 expression. There was a weak negative correlation between STK24 expression and its DNA methylation (Pearson's r = -0.32).
CONCLUSION: Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation.

PMID: 29557182 [PubMed - indexed for MEDLINE]

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