Rapid determination of quaternary protein structures in complex biological samples

Rapid determination of quaternary protein structures in complex biological samples

Rapid determination of quaternary protein structures in complex biological samples, Published online: 14 January 2019; doi:10.1038/s41467-018-07986-1

Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria.

from A via a.sfakia on Inoreader https://go.nature.com/2QNlhv4