Intensiometric biosensors visualize the activity of multiple small GTPases in vivo

Intensiometric biosensors visualize the activity of multiple small GTPases in vivo

Intensiometric biosensors visualize the activity of multiple small GTPases in vivo, Published online: 14 January 2019; doi:10.1038/s41467-018-08217-3

FRET sensors hardly achieve visualization of spatiotemporal dynamics of protein activity in vivo. Here the authors present intensiometric small GTPase biosensors based on dimerization-dependent fluorescent proteins that enable monitoring of activity of small GTPases in the brains of behaving mice at a single spine resolution.

from A via a.sfakia on Inoreader https://go.nature.com/2QLkqLB