Prognostic Value of Neutrophil-to-Lymphocyte Ratio in predicting the 6-Month Outcome of Traumatic Brain Injury Patients: A Retrospective Study.

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in predicting the 6-Month Outcome of Traumatic Brain Injury Patients: A Retrospective Study.

World Neurosurg. 2019 Jan 02;:

Authors: Zhao JL, Du ZY, Yuan Q, Yu J, Sun YR, Wu X, Li ZQ, Wu XH, Hu J

Abstract
BACKGROUND: Peripheral white blood cells (WBC) are regularly analyzed upon admission for traumatic brain injury (TBI) patients. The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) in predicting the 6-month outcome of TBI patients is unclear.
METHODS: We designed a single-center retrospective cohort study. Patients admitted to Fudan University Huashan Hospital within 6 hours after TBI were identified between Dec.2004 and Dec.2017. The primary outcome was 6-month GOS score. Independent predictors of 6-month outcome were assessed using uni- and multivariate analyses. Three models based on admission characteristics were built to evaluate the prognostic value of NLR to the outcome of TBI patients. The discriminative ability of predictive models was evaluated by the area under the curve (AUC).
RESULTS: A total of 1291 TBI patients were included. Multivariate analysis showed age, GCS scores at admission, SDH, IPH tSAH, NLR (p<0.001) and coagulopathy (p=0.028) were independent predictors of the 6-month outcome. The model combining NLR and standard variables (AUC=0.936; 95% CI, 0.923-0.949) was more favorable in predicting the 6-month outcome of TBI patients than the model without NLR (AUC=0.901; 95% CI, 0.883-0.919) and the model based only on NLR (AUC=0.827; 95% CI, 0.802-0.852).
CONCLUSIONS: NLR is an independent prognostic factor of the 6-month outcome in TBI patients. A high NLR in TBI patients is associated with poor outcome. The prognostic value of NLR to the 6-month outcome of TBI patients is favorable.

PMID: 30610986 [PubMed - as supplied by publisher]

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