Ni‐Catalyzed Asymmetric Reductive Diarylation of Vinylarenes

A Ni‐catalyzed asymmetric diarylation reaction of vinylarenes represents a compelling method for preparing chiral α,α,β‐triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners avoids stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N‐oxyl radical as a ligand to Ni catalysts represents a novel approach to facilitate Ni‐catalyzed cross‐coupling reactions.

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