Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides, Published online: 02 January 2019; doi:10.1038/s41467-018-07826-2

Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-Wolbachia drugs.

from A via a.sfakia on Inoreader https://go.nature.com/2RtQub8