GABAA receptor signalling mechanisms revealed by structural pharmacology
GABA<sub>A</sub> receptor signalling mechanisms revealed by structural pharmacology, Published online: 02 January 2019; doi:10.1038/s41586-018-0832-5
Cryo-electron microscopy structures are reported in which the full-length human α1β3γ2L GABAA receptor in lipid nanodiscs is bound to the channel-blocker picrotoxin, the competitive antagonist bicuculline, the agonist GABA, and the benzodiazepines alprazolam and diazepam.
from A via a.sfakia on Inoreader https://go.nature.com/2Ar0BUu
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,