[Urinary biomarkers for chronic kidney disease: a focus on gene transcript].

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[Urinary biomarkers for chronic kidney disease: a focus on gene transcript].

Sheng Li Xue Bao. 2018 Dec 25;70(6):644-648

Authors: Lyu LL, Liu BC

Abstract
Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. This review will discuss the recent advances in biomarker study from urine sediment, urine supernatant and urinary extracellular vesicles with special interest in gene transcript (miRNA, mRNA) biomarkers. Besides, the challenges and future directions for urinary gene transcript biomarker study will be discussed.

PMID: 30560274 [PubMed - in process]

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