Structural basis of Notch recognition by human γ-secretase
Structural basis of Notch recognition by human γ-secretase, Published online: 31 December 2018; doi:10.1038/s41586-018-0813-8
The cryo-electron microscopy structure of human γ-secretase in complex with its substrate Notch reveals pronounced structural rearrangements compared to the apo enzyme, including formation of a β-sheet involving residues from both enzyme and substrate.
from A via a.sfakia on Inoreader https://go.nature.com/2TkBQjH
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,