Pd(II)‐Catalyzed Regio‐ and Enantioselective Oxidative C‐H/C‐H Cross‐Coupling Reaction between Ferrocenes and Azoles

Asymmetric C‐H bond functionalization reaction is one of the most efficient and straightforward methods for the synthesis of optically active molecules. Herein we disclose an asymmetric C‐H/C‐H cross‐coupling reaction of ferrocenes with azoles such as oxazoles and thiazoles. Palladium(II)/monoprotected amino acid (MPAA) catalytic system exhibits excellent reactivity and regioselectivity for oxazoles and thiazoles. This method offers a powerful strategy for constructing planar chiral ferrocenes. Mechanistic studies suggest that the C‐H bond cleavage of azoles is likely proceeding via a SEAr process and may not be a turnover limiting step.

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