POSSIBLE IMPLEMENTATION OF GABAERGIC AND GLUTAMATERGIC SYSTEMS IN REALIZATION OF ANTIEPILEPTIC EFFECTS OF ACOUSTIC RANGE ELECTRO - MAGNETIC FIELDS.

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POSSIBLE IMPLEMENTATION OF GABAERGIC AND GLUTAMATERGIC SYSTEMS IN REALIZATION OF ANTIEPILEPTIC EFFECTS OF ACOUSTIC RANGE ELECTRO - MAGNETIC FIELDS.

Georgian Med News. 2018 Jul-Aug;(280-281):112-116

Authors: Bukia N, Butskhrikidze M, Machavariani L, Kekelia G, Svanidze M

Abstract
Seizure is a clinical manifestation of a hyperexcitable neuronal network, in which, the electrical balance underlying the normal neuronal activity is altered pathologically-excitation (Glutamatergic activity) predominates over inhibition (GABAergic activity). Arresting of seizure activity is carried out by restoration of neurotransmitter balance. This process has a direct relation with ion channel permeability in cell and ion transmembrane movement. Low frequency EMS may have a neurostimulating and neuromodulating effect that is based on electromagnetic induction of electric field in the brain. Under the conditions of certain amplitude, frequency and relaxation time low-frequency electromagnetic field (EMF) induces depolarization of separate neurons, and changes the total cortical excitability in case of repeatedly carried out procedures. It was shown that the exposure of acoustic range EMS in GEPRs treated with GABA-A or GABA-B receptors antagonists decreased behavior seizure activity in response to audiogenic stimuli. Injection of Glutamate receptor agonist on background EMS causes seizure activity, but seizure manifestations have less degree compared to non-stimulated rats. Thus, in response to electromagnetic stimulation, the reduction or complete cramping of seizures can be explained by a change in the activity of the neurotransmitter systems.

PMID: 30204107 [PubMed - indexed for MEDLINE]

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