Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines, Published online: 13 December 2018; doi:10.1038/s41467-018-07753-2

During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.

from A via a.sfakia on Inoreader https://ift.tt/2C9It2Q