Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
Control of T<sub>reg</sub> cell homeostasis and immune equilibrium by Lkb1 in dendritic cells, Published online: 13 December 2018; doi:10.1038/s41467-018-07545-8
Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,