Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen induced allergic rhinitis in mice.

Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen induced allergic rhinitis in mice.

J Appl Microbiol. 2017 Nov 12;:

Authors: Choi SP, Oh HN, Choi CY, Ahn H, Yun HS, Chung YM, Kim B, Lee SJ, Chun T

Abstract
AIMS: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis.
METHODS AND RESULTS: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness (AHR), and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage (BAL) fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ), and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE, and BP-specific serum IgG1 were decreased, whereas secretion of IFN-γ and BP-specific serum IgG2a were augmented upon administration of CJLP133 and CJLP243 in mice.
CONCLUSION: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response.
SIGNIFICANCE AND IMPACT OF THE STUDY: Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model. This article is protected by copyright. All rights reserved.

PMID: 29130606 [PubMed - as supplied by publisher]

from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2hzeYQB
via IFTTT