In reference to “Central nervous system anomalies in craniofacial microsomia: a systematic review”

We read with interest the in-depth review by Renkema and colleagues on central nervous system (CNS) involvement in patients affected by craniofacial microsomia1. In this article, the authors clearly showed that CNS abnormalities are commonly detected (2–69%), thus confirming that malformations in craniofacial microsomia go far beyond isolated skeletal abnormalities. The authors also underlined the need to investigate further the true prevalence rate of CNS involvement through the performance of dedicated studies, and attributed the wide range of CNS abnormality detection rates to selection bias, as patients with neurological symptoms are more likely to undergo neuroimaging studies.

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