Assessment of alveolar bone marrow fat content using 15T MRI

Publication date: Available online 21 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Arthur Rodriguez Gonzalez Cortes, Ouri Cohen, Ming Zhao, Eduardo Massaharu Aoki, Rodrigo Alves Ribeiro, Lina Abu Nada, Claudio Costa, Emiko Saito Arita, Faleh Tamimi, Jerome L. Ackerman
ObjectivesBone marrow fat is inversely correlated with bone mineral density. The aim of this study is to present a method to quantify alveolar bone marrow fat content using a 15T MRI scanner.Study DesignA 15T MRI scanner with a 13-mm ID loop-gap radiofrequency coil was used to scan seven 3 mm diameter alveolar bone biopsy specimens. A 3D gradient-echo (GRE) T1-weighted pulse sequence was chosen to obtain images. All images were obtained with a voxel size (58 µm³) sufficient to resolve trabecular spaces. Automated volume of the bone marrow fat content and derived bone volume fraction (BV/TV) were calculated. Results were compared with actual BV/TV obtained from micro-CT scans.ResultsMean fat tissue volume was 20.1 ± 11%. There was a significantly strong inverse correlation between fat tissue volume and BV/TV (r = –0.68, p = 0.045). Furthermore, there was a strong agreement between BV/TV derived from MRI and obtained with Micro-CT (ICC = 0.92, p = 0.001).ConclusionBone marrow fat of small alveolar bone biopsy specimens can be quantified with sufficient spatial resolution using an ultra-high-field MRI scanner and a T1-weighted pulse sequence.



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