Understanding DNA replication by the bacteriophage T4 replisome [DNA and Chromosomes]

The T4 Replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on: its eight proteins composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison to other replisomes with emphasis on how coordinated DNA replication is achieved.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2g4LVQv
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