Nuclear receptor corepressor 1 (NCoR1) is considered to be the major corepressor that mediates ligand-independent actions of the thyroid hormone receptor (TR) during development and in hypothyroidism. We tested this by expressing a hypomorphic NCoR1 allele (NCoR1ΔID), which cannot interact with the TR, in Pax8-KO mice, which make no thyroid...
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Τρίτη 3 Οκτωβρίου 2017
NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor [Medical Sciences]
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