Lipid topology and electrostatic interactions underpin lytic activity of linear cationic antimicrobial peptides in membranes [Biochemistry]

Linear cationic antimicrobial peptides are a diverse class of molecules that interact with a wide range of cell membranes. Many of these peptides disrupt cell integrity by forming membrane-spanning pores that ultimately lead to their death. Despite these peptides high potency and ability to evade acquired bacterial drug resistance, there...

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