Investigating of four main carbapenem-resistance mechanisms in high-level carbapenem resistant Pseudomonas aeruginosa isolated from burn patients

Pseudomonas aeruginosa is an opportunistic pathogen involved in many infections. Carbapenem-resistant P. aeruginosa has emerged as an important cause of infection in different hospitals worldwide. We aimed to determine frequencies of the four main resistance mechanisms [metallo-beta lactamase (MBL) production (blaIMP, blaVIM, blaSPM and blaNDM), overproduction of the MexAB–OprM and MexXY efflux pumps, overproduction of chromosome-encoded AmpC β–lactamase, and reduced OprD expression] in high-level carbapenem-resistant P.

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