The factors and steps controlling postinfection CD8+ T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that naive TCF7 (alias "Tcf-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent expression of the memory-essential transcription factor TCF7 in pathogen-specific CD8+ T cells. We determined the...
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Τρίτη 17 Οκτωβρίου 2017
FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity [Immunology and Inflammation]
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