Traumatic brain injury (TBI) can lead to physical and cognitive deficits, which are caused by the secondary injury process. Effective pharmacotherapies for TBI patients are still lacking. Fibroblast growth factor-2 (FGF2) is an important neurotrophic factor that can stimulate neurogenesis and angiogenesis and has been shown to have neuroprotective effects after brain insults. Previous studies indicated that FGF2's neuroprotective effects might be related to its function of regulating autophagy. The present study investigated FGF2's beneficial effects in the early stage of rat mild TBI and the underlying mechanisms. One hundred and forty-four rats were used for creating controlled cortical impact (CCI) models to simulate the pathological damage after TBI. Our results indicated that pretreatment of FGF2 played a neuroprotective role in the early stage of rat mild TBI through alleviating brain edema, reducing neurological deficits, preventing tissue loss, and increasing the number of surviving neurons in injured cortex and the ipsilateral hippocampus. FGF2 could also protect cells from various forms of death such as apoptosis or necrosis through inhibition of autophagy. Finally, autophagy activator rapamycin could abolish the protective effects of FGF2. This study extended our understanding of FGF2's neuroprotective effects and shed lights on the pharmacological therapy after TBI.
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2yroPMb
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
-
▼
Οκτωβρίου
(11955)
-
▼
Οκτ 17
(529)
- Azacitidine-induced Sweet syndrome: Two unusual cl...
- Treatment of Hailey–Hailey disease with botulinum ...
- Female gonadal shielding with automatic exposure c...
- Study finds lamotrigine to be safe during pregnancy
- Treating Hepatitis C Infection in Patients With Ch...
- Consumer health information seeking in social medi...
- Predictors of Clinicopathologic Stage Discrepancy ...
- Risk of Development of Second Primary Head and Nec...
- Periostin as a Biomarker for Nasal Polyps in Chron...
- Desmoplastic Small Round Cell Tumor Presenting as ...
- Targeting the ubiquitin-proteasome system for canc...
- Viruses, Vol. 9, Pages 302: Marine Viruses: Key Pl...
- Medication-related osteonecrosis of the jaw (MRONJ...
- Identification of Aptamers That Bind to Sickle Hem...
- Perioperative management of paraganglioma and cate...
- Preparing for the unexpected: special consideratio...
- Intraoperative continuous cerebral microcirculatio...
- Role of tube size and intranasal compression of th...
- Dynamic Risk Stratification in Stage I Papillary T...
- Rebuttal to Smith and Janssen
- Diffuse large B cell lymphoma
- Anti-human immunodeficiency virus-1 activities of ...
- Shenyi Capsule (参一胶囊) plus chemotherapy versus che...
- Prediction of protein complexes in Trypanosoma bru...
- Anti-human immunodeficiency virus-1 activities of ...
- Shenyi Capsule (参一胶囊) plus chemotherapy versus che...
- Study finds lamotrigine to be safe during pregnancy
- Human pupillary light reflex during successive irr...
- Designing equitable workplace dietary intervention...
- New dentist is part of the drill in Eyota
- Relationship between dietary factors and bisphenol...
- Bisphenol A promotes hyperuricemia via activating ...
- Export of membrane proteins from the Golgi complex...
- Biased signaling of the proton-sensing receptor OG...
- Zinc finger protein 365 is a new maternal LPS-bind...
- Peptide YY mediates the satiety effects of diets e...
- Alternaria alternata (Fr.) Keissl with mutation G1...
- MBSAQIP Database Should Be Used as a Tool to Conti...
- The Gut Microbiome in Obesity: A New Frontier in T...
- Medical tourism: A Financial and Ethical Problem i...
- The Role of the Human Microbiome in Obesity-relate...
- Update on ASMBS/ACS Metabolic and Bariatric Surger...
- Walter Pories’s Cartoon Corner
- SOCS1 gene therapy improves radiosensitivity and e...
- Restoration of natural killer cell anti-metastatic...
- Autophagy induction under carbon starvation condit...
- Plant pathogenesis-related proteins of the cacao f...
- A genome-wide screen in Escherichia coli reveals t...
- Wilms tumor protein-dependent transcription of VEG...
- The Serum Protein Renalase Reduces Injury in Exper...
- Posttranslational processing and membrane transloc...
- Analysis of substrate specificity of Trypanosoma b...
- Development of novel biosensors to study receptor-...
- 1{alpha},25-Dihydroxyvitamin D3 promotes bone form...
- Mammalian Numb protein antagonizes Notch by contro...
- Transcription factor 19 interacts with histone 3 l...
- Estimation of meteorological drought indices based...
- Early identification and intervention matters: A c...
- Astronaut wee could show us how the plumes on Ence...
- Butchery of a black rhino wins Wildlife Photograph...
- Early identification and intervention matters: A c...
- Multiscale Thermal Hydraulic Study under the Inadv...
- The Global Optimal Algorithm of Reliable Path Find...
- A Case of Invasive Pneumococcal Infection with Sep...
- Surface Corrosion and Microstructure Degradation o...
- The Cascadic Multigrid Method of the Weak Galerkin...
- First-Line Helicobacter pylori Eradication with Vo...
- Irreversible Thermodynamic Description of Dark Mat...
- Shorter Decentralized Attribute-Based Encryption v...
- Evaluation of Electrospun Nanofiber-Anchored Silic...
- Recent Progress on the Description of Relativistic...
- High Fasting Plasma Glucose during Early Pregnancy...
- (2 + 1)-Dimensional Coupled Model for Envelope Ros...
- Polymicrobial blood stream infection: Consensus de...
- Capillary leak syndrome following snakebite enveno...
- A pilot study of nebulized heparin for prevention ...
- Epidemiological study of patients of road traffic ...
- Enhancing hospital well-being and minimizing inten...
- Hypercapnic respiratory failure in case of chiari ...
- The effects of atorvastatin on inflammatory respon...
- Mapping the characteristics of critical care facil...
- Astronaut wee could show us how the plumes on Ence...
- Butchery of a black rhino wins Wildlife Photograph...
- Plasmacytoid dendritic cells drive acute exacerbat...
- Mysterious particles spotted in Saturn’s atmosphere
- Ancient bird gland gives up its chemical secrets
- Multi-site lymphatic venous anastomosis using echo...
- Three-stage folded forehead flap for nasal reconst...
- Investigating the pros and cons of browns gas and ...
- Determination of element composition and extraterr...
- Adsorption and desorption for dynamics transport o...
- Assessment of filtration efficiency and physiologi...
- Pediatric tinnitus: Incidence of imaging anomalies...
- Castillo Morales Appliance Therapy in the treatmen...
- Epidemiological characteristics of pediatric epist...
- Targeted next generation sequencing identified a n...
- Incidence and factors associated with revision ade...
- Factors associated with 30-day all-cause hospital ...
- Pediatric tinnitus: Incidence of imaging anomalies...
- Castillo Morales Appliance Therapy in the treatmen...
-
▼
Οκτ 17
(529)
- ► Σεπτεμβρίου (12424)
Ετικέτες
Πληροφορίες
Τρίτη 17 Οκτωβρίου 2017
FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,